ATPase (Na+K+)

Enzymes in this class are ATPases that are involved in catalyzing transmembrane movement of substances, e.g. the exchange of extracellular potassium (K+) for cytoplasmic ions, being either Na+ and/or Ca2+ (EC 3.6.3.9) in order to maintain the resting potential avail transport, and regulate cellular volume, or H+ (EC 3.6.3.10) in order to promote gastric acid secretion. Digoxin (Axon 1649) and its active metabolite (Axon 1695) for example, are known to be a unique medication with pharmacological effects resulting in hemodynamic, sympatholytic, and electrophysiologic changes. Their primary mechanism of action is inhibition of the Na+/K+ ATPase pump, thereby promoting Na+/Ca2+ exchange, which results in an influx of intracellular Ca2+ and increased myocardial contraction[1]. Besides this, recent studies revealed that digoxin also targets the transcription factor Hypoxia inducible factor HIF-1 by potently inhibiting HIF-1α mRNA translation. As a result, Digoxin administration increased latency and decreased growth of tumor xenografts, whereas treatment of established tumors resulted in growth arrest within one week[2].

ATPases listed: ATPase (cardiac specific myosin), ATPase (p97), ATPase (H+/K+), ATPase (Na+/K+)


[1] M. Ehle et al.Digoxin: Clinical Highlights: A Review of Digoxin and Its Use in Contemporary Medicine. Crit. Path. Cardiol. J. E. B. Med. 2011, 10, 93-98.
[2] H. Zhang et al. Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth. PNAS 2008, 105, 19579-19586.

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Axon ID Name Description From price
1695 Digoxigenin bis-digitoxiside Metabolite of Digoxin €155.00
1649 Digoxin Na+/K+ ATPase pump inhibitor €75.00

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