HRV3C Protease

Human rhinoviruses (HRVs) comprise over 100 different serotypes and are the predominant cause of the common cold. Although HRV infections are generally mild and self-limiting, they can also be associated with more serious illnesses, specifically, exacerbation of disease in individuals with underlying respiratory disorders. HRVs are a group of small single-stranded positive-sense RNA viruses that translate their genetic information into a polyprotein precursor that is mainly processed by a virally encoded 3C protease (3Cpro; EC 3.4.22.28) to generate functional viral proteins and enzymes. The enzymatic activity of HRV 3Cpro is essential to viral replication, and is distinguished from most other proteases by the fact that it has a cysteine nucleophile but with a chymotrypsin-like serine protease folding. This unique protein structure together with its essential role in viral replication made the 3Cpro an excellent target for antiviral intervention[1].  


[1] Q.M. Wanga et al. Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept. Sci. 2007, 8, 19-27.

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1571 AG 7088 HRV3C protease inhibitor €135.00

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