LTA4H

LTA4H

Leukotriene A4 hydrolase/aminopeptidase (LTA4H; EC 3.3.2.6) is a ubiquitously expressed bifunctional zinc metalloenzyme with epoxide hydrolase and aminopeptidase activities utilizing the same Zn present active site. It catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme’s endogenous peptidase substrate.

Read More
sort-descending
  • ARM1 hydrobromide
    2307
    ARM1 hydrobromide
    The price depends on the options chosen on the product page

    From $101.20

1 Item

More About LTA4H

Leukotriene A4 hydrolase/aminopeptidase (LTA4H; EC 3.3.2.6) is a ubiquitously expressed bifunctional zinc metalloenzyme with epoxide hydrolase and aminopeptidase activities utilizing the same Zn present active site. It catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme’s endogenous peptidase substrate[1],[2].

[1] S. Thangapandian et al. Molecular dynamics simulation study and hybrid pharmacophore model development in human LTA4H inhibitor design. PLoS One. 2012, 7, e34593.
[2] A.M. Fourie. Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase. Curr. Opin. Investig. Drugs. 2009, 10, 1173-1182.

Loading...