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ARM1 hydrobromide

Axon 2307
  • Parent CAS:  68729-05-5
Purity:  99%
  • Soluble in DMSO
  • MF:  C16H14N2S.HBr
  • MW:  347.27

Description

ARM1 hydrobromide is a leukotriene A4 hydrolase (LTA4H) inhibitor that selectively blocks conversion of LTA4 to the pro-inflammatory mediator LTB4 while preserving aminopeptidase activity toward Pro-Gly-Pro. It shows an IC50 of approximately 0.5 μM in human neutrophils and a Ki of 2.3 μM for purified LTA4H.

LTA4H is a bifunctional zinc metalloenzyme linking leukotriene biosynthesis to regulation of chemotactic peptide turnover. ARM1 is useful for separating LTB4-generating hydrolase activity from LTA4H aminopeptidase biology in inflammatory models.

Key Features

  • Selective LTA4H hydrolase-pathway inhibitor
  • IC50: approximately 0.5 μM in human neutrophils
  • Ki: 2.3 μM for purified LTA4H
  • Preserves Pro-Gly-Pro aminopeptidase activity

Applications

  • Leukotriene pathway research
  • Neutrophil inflammation assays
  • LTA4H pharmacology
  • Eicosanoid-mediated inflammatory disease models

More Information

Parent CAS No. 68729-05-5
Chemical Name 4-(4-benzylphenyl)thiazol-2-amine hydrobromide
SMILES S1C=C(C2=CC=C(CC3=CC=CC=C3)C=C2)N=C1N.Br
MFCD MFCD06653257
InChi InChI=1S/C16H14N2S.BrH/c17-16-18-15(11-19-16)14-8-6-13(7-9-14)10-12-4-2-1-3-5-12;/h1-9,11H,10H2,(H2,17,18);1H
InChiKey JNODWABIDXRUJK-UHFFFAOYSA-N
CID 16495486
Short Description LTA4H inhibitor

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