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Ivachtin
- Moderately soluble in DMSO
- MF: C20H21N3O7S
- MW: 447.46
Description
Ivachtin is a cell-permeable and reversible caspase-3 inhibitor with a reported IC50 value of 23 nM.
Caspase-3 is a central executioner protease in apoptotic cell death. Ivachtin is used to suppress caspase-3-dependent substrate cleavage, DNA fragmentation and downstream apoptotic phenotypes in cellular models.
Key Features
- Potent reversible caspase-3 inhibitor
- Reported IC50: 23 nM
- Cell-permeable anti-apoptotic tool compound
- Blocks execution-phase caspase signaling
Applications
- Caspase-3 enzyme and activity assays
- Apoptosis and programmed cell-death studies
- DNA fragmentation and substrate-cleavage models
- Cell-protection and ischemic-injury research
More Information
| Parent CAS No. | 745046-84-8 |
|---|---|
| Chemical Name | 2-(4-Methyl-8-(morpholinosulfonyl)-1,3-dioxo-1H-pyrrolo[3,4-c]quinolin-2(3H)-yl)ethyl acetate |
| SMILES | C12N=C(C)C3C(=O)N(CCOC(C)=O)C(=O)C=3C=1C=C(S(=O)(=O)N1CCOCC1)C=C2 |
| MFCD | MFCD09971108 |
| InChi | InChI=1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3 |
| InChiKey | MWXJJTMEUGWKKY-UHFFFAOYSA-N |
| CID | 11201705 |
| Short Description | Caspase-3 inhibitor |
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