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Boc-D-FMK
- Boc-Asp(OMe)-fluoromethyl ketone - BAF
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C11H18FNO5
- MW: 263.26
Description
Boc-D-FMK is a broad-spectrum caspase inhibitor that blocks apoptosis-associated caspase activity. It inhibits TNFα-stimulated apoptosis in a concentration-dependent manner, with reported IC50 of 39 µM in the cited assay.
Caspases coordinate apoptotic execution and contribute to tissue damage after neurotrauma and inflammatory cell death. Boc-D-FMK is relevant for apoptosis pathway studies, neuroprotection models and caspase-dependency experiments.
Key Features
- Broad-spectrum caspase inhibitor
- Suppresses TNFα-stimulated apoptosis
- Modulates mitochondrial cytochrome c-associated cell death
- Reported neuroprotective effects in injury models
Applications
- Apoptosis pathway research
- Caspase activity assays
- Traumatic brain injury model studies
- Motoneuron survival and neuroprotection experiments
More Information
| Parent CAS No. | 187389-53-3 |
|---|---|
| Chemical Name | (S)-methyl 3-(tert-butoxycarbonylamino)-5-fluoro-4-oxopentanoate |
| SMILES | C(OC)(=O)C[C@H](NC(OC(C)(C)C)=O)C(=O)CF |&1:5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1 |
| InChiKey | MXOOUCRHWJYCAL-ZETCQYMHSA-N |
| CID | 9881695 |
| Short Description | Caspase inhibitor |
References
- M.D. Witte et al. Bodipy-VAD-Fmk, a useful tool to study yeast peptide N-glycanase activity. Org. Biomol. Chem. 2007,5, 3690-3697.
- Y.M. Chan et al. Caspase inhibitors promote the survival of avulsed spinal motoneurons in neonatal rats. Neurorep. 2001, 12,541-545.
- R.S. Clark et al. boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. J. Cereb. Blood Flow Metab. 2007, 27, 316-326.
- A.S. Cowburn et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. Blood. 2005, 105, 2970-2972.
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