Cathepsin-K

Cathepsin K (Cat K, CTSK; EC 3.4.22.8) is a member of the CA1 family of lysosomal cysteine proteases and of the papain family. It is considered to be the major enzyme responsible for degradation of the organic bone matrix. It is highly and selectively expressed in osteoclasts and, under acidic conditions, has the unique ability to degrade type I collagen helical regions. Unlike the other cathepsins, Cat K not only degrades type I collagen in the telopeptide regions, but is capable of cleaving the triple helical domains at multiple sites. The protease is an attractive target for inhibition of bone resorption[1].


[1] S.B. Rodan et al. Cathepsin K – A new molecular target for osteoporosis. IBMS BoneKEy 2008, 5, 16-24. 

3 Item(s)

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Axon ID Name Description From price
2154 Balicatib Selective inhibitor of cathepsin K €80.00
1771 MK 0822 Inhibitor of cathepsin K €85.00
2156 ONO 5334 Potent and orally available inhibitor of cathepsin K €110.00

3 Item(s)

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