PLD

Phosphatidic acid (PA) is a lipid second messenger located at the intersection of several lipid metabolism and cell signaling events including membrane trafficking, survival, and proliferation. Generation of signaling PA has long been primarily attributed to the activation of phospholipase D (PLD; EC3.1.4.4). PLD catalyzes the hydrolysis of phosphatidylcholine into PA. A variety of both receptor-tyrosine kinase and G-protein-coupled receptor stimulations have been shown to lead to PLD activation and PA generation[1].

Phosphodiesterases listed: PDE, PLC, PLD


[1] S.A. Scott et al. Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation. J. Biol. Chem. 2013, 288, 20477-20487. 

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Axon ID Name Description From price
2281 FIPI hydrochloride Phospholipase D (PLD) inhibitor that blocks phosphatidic acid (PA) production in vivo €100.00

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