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FIPI hydrochloride
Axon 2281
- Parent CAS: 939055-18-2
Purity:
99%
- Soluble in DMSO
- MF: C23H24FN5O2.HCl
- MW: 457.93
Description
FIPI hydrochloride is a phospholipase D inhibitor that blocks both PLD1 and PLD2 with IC50 values of 20–25 nM and rapidly suppresses phosphatidic acid production in cells. It disrupts PLD-dependent regulation of the actin cytoskeleton, PIP2 availability, cell spreading and chemotaxis.
PLD-generated phosphatidic acid is an important lipid second messenger in inflammation, migration, vesicle trafficking and cancer biology. FIPI hydrochloride is useful for probing PLD-dependent lipid signaling and cellular motility.
Key Features
- Potent PLD1/PLD2 inhibitor
- IC50: 20–25 nM at PLD1 and PLD2
- Suppresses phosphatidic acid production
- Disrupts PLD-dependent cytoskeletal regulation
Applications
- Phospholipase D pharmacology
- Lipid signaling studies
- Chemotaxis and cell migration assays
- Inflammation and cancer-metastasis research
More Information
| Parent CAS No. | 939055-18-2 |
|---|---|
| Chemical Name | 5-fluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide hydrochloride |
| SMILES | N1C2=C(C=C(F)C=C2)C=C1C(NCCN1CCC(N2C(=O)NC3=CC=CC=C32)CC1)=O.Cl |
| MFCD | MFCD18382115 |
| InChi | InChI=1S/C23H24FN5O2.ClH/c24-16-5-6-18-15(13-16)14-20(26-18)22(30)25-9-12-28-10-7-17(8-11-28)29-21-4-2-1-3-19(21)27-23(29)31;/h1-6,13-14,17,26H,7-12H2,(H,25,30)(H,27,31);1H |
| InChiKey | BNMQCDOCYPGJJD-UHFFFAOYSA-N |
| CID | 90488864 |
| Short Description | PLD inhibitor |
References
- W. Su et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol. Pharmacol. 2009, 75, 437-446.
- L. Monovich et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg. Med. Chem. Lett. 2007, 17, 2310-2311.
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