RGS4

RGS4

The regulator of G-protein signaling 4 (RGS4) is a protein of the class of GTPase activating proteins (GAP) and shows no GTPase activity by itself. Instead, RGS proteins are negative regulators of G alpha subunits of heterotrimeric G proteins (Gi, Go, and Gq). Because its functions is inherently part of the well functioning of these heterotrimeric G proteins (EC 3.6.5.1), inhibitors of RGS4 are listed in this particular section.

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More About RGS4

The regulator of G-protein signaling 4 (RGS4) is a protein of the class of GTPase activating proteins (GAP) and shows no GTPase activity by itself. Instead, RGS proteins are negative regulators of G alpha subunits of heterotrimeric G proteins (Gi,  Go, and Gq)[1]. Because its functions is inherently part of the well functioning of these heterotrimeric G proteins  (EC 3.6.5.1), inhibitors of RGS4 are listed in this particular section.

[1] N. Grillet et al. Generation and Characterization of Rgs4 Mutant Mice. Mol. Cell Biol. 2005, 25, 4221-4228.

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