Esterases (Thio-)
Thioesterases are enzymes that hydrolyse thioesters between a carbonyl group and a sulfur atom. in the presence of water, and are identified as members of E.C.3.1.2. Substrates of 15 of these 27 groupings contain coenzyme A (CoA), two contain acyl carrier proteins (ACPs), four have glutathione or its derivatives, one has ubiquitin, and two contain other moieties. Acetyl-CoA hydrolase, palmitoyl-CoA hydrolase, succinyl-CoA hydrolase, formyl-CoA hydrolase, acyl-CoA hydrolase are a few examples of this group of enzymes[1].
[1] DC Cantu et al. Thioesterases: a new perspective based on their primary and tertiary structures. Protein Sci. 2010 Jul;19(7):1281-95.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
3968 | Darapladib | Selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor | Recently added | Inquire |
2646 | ML348 | Selective inhibitor for acyl-protein thioesterase APT1 (aka LYPLA1) | €95.00 |