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Darapladib
- SB-480848
Axon 3968
CAS:
356057-34-6
Purity:
99%
- Soluble in DMSO
- MF: C36H38F4N4O2S
- MW: 666.77
Description
Darapladib is a selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor.
More Information
| Parent CAS No. | 356057-34-6 |
|---|---|
| Chemical Name | N-(2-(Diethylamino)ethyl)-2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)acetamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(F)C=CC(CSC2=NC(=O)C3CCCC=3N2CC(=O)N(CCN(CC)CC)CC2C=CC(C3C=CC(C(F)(F)F)=CC=3)=CC=2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3 |
| InChiKey | WDPFJWLDPVQCAJ-UHFFFAOYSA-N |
| CID | 9939609 |
| Short Description | APT2 inhibitor |
References
- JA Blackie et al. The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1067-70.
- MM Hu et al. The inhibition of lipoprotein-associated phospholipase A2 exerts beneficial effects against atherosclerosis in LDLR-deficient mice. Acta Pharmacol Sin. 2011 Oct;32(10):1253-8.
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