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Palmitoylethanolamide
- Soluble in EtOH
- MF: C18H37NO2
- MW: 299.49
Description
Palmitoylethanolamide is an endogenous N-acylethanolamine lipid mediator with endocannabinoid-like pharmacology and reported activity in GPR55- and PPARα-associated signaling systems.
Palmitoylethanolamide is studied for its ability to modulate inflammatory, nociceptive and glial responses without acting as a classical CB1 or CB2 cannabinoid agonist. It is relevant to lipid mediator biology, neuroinflammation and pain pathway research.
Key Features
- Endogenous endocannabinoid-like lipid mediator
- Associated with GPR55 and PPARα-linked signaling
- Modulates inflammatory and nociceptive pathways
- Useful for lipid mediator and cannabinoid-adjacent pharmacology
Applications
- Lipid mediator biology
- GPR55 and PPARα pathway studies
- Neuroinflammation and pain model research
- Endocannabinoid system modulation assays
More Information
| Parent CAS No. | 544-31-0 |
|---|---|
| Chemical Name | Hexadecanoic acid (2-hydroxy-ethyl)-amide |
| SMILES | C(CCCCCCCC)CCCCCCC(=O)NCCO |
| MFCD | MFCD00020562 |
| InChi | InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21) |
| InChiKey | HXYVTAGFYLMHSO-UHFFFAOYSA-N |
| CID | 4671 |
| Short Description | GPR55 agonist |
References
- V di Marzo et al. Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem. J. 2001, 358, 249-255.
- S Conti et al. Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. Br. J. Pharmacol. 2002, 135, 181-187.
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