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Cannabidiol
- CBD
- Soluble in DMSO
- MF: C21H30O2
- MW: 314.46
Description
Cannabidiol is a non-intoxicating phytocannabinoid that does not behave as a classical CB1 or CB2 agonist and has been reported to antagonize GPR55-mediated signaling.
Cannabidiol is pharmacologically pleiotropic and is used to study cannabinoid-adjacent mechanisms, including GPR55, TRP channels, 5-HT1A-associated pathways, neuroinflammation and neuronal excitability.
Key Features
- Non-intoxicating cannabinoid research compound
- Reported GPR55 antagonist activity
- Does not act as a classical CB1/CB2 agonist
- Useful for studying cannabinoid-adjacent signaling pathways
Applications
- GPR55 and endocannabinoid pathway studies
- Neuroinflammation and neuronal excitability research
- Cannabinoid receptor selectivity profiling
- Pain, seizure and CNS model research
More Information
| Parent CAS No. | 13956-29-1 |
|---|---|
| Chemical Name | 2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol |
| MFCD | MFCD00869597 |
| Short Description | GPR55 antagonist |
References
- A Thomas et al. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br. J. Pharmacol. 2007,150 (5), 613–23.
- E Ryberg et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br. J. Pharmacol. 2007, 152, 1092–1101.
- LE Long et al. The pharmacological actions of cannabidiol. Drugs Fut. 2005, 30(7), 747-753.
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