A class of aminopeptidases, widely distributed throughout the animal and plant kingdoms, and found in many subcellular organelles, in cytoplasm, and as membrane components. The aminopeptidase MetAP2 (EC 22.214.171.124) is of particular interest because the enzyme plays a key role in angiogenesis, the growth of new blood vessels, which is necessary for the progression of diseases including solid tumor cancers and rheumatoid arthritis.
 Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models. M.J. Morowitz et al. Clin. Cancer Res. 2005, 11, 2680-2685.