Helicase-Primase

Helicase-Primase

Nearly all aspects of RNA metabolism, from transcription and translation to mRNA decay, involve RNA helicases, which are enzymes that use ATP to bind or remodel RNA and DNA and their protein complexes (e.g. ribonucleoprotein (RNP) complexes). RNA helicases are found in all three domains of life, and many viruses also encode one or more of these proteins. Together with the structurally related DNA helicases that function in replication, recombination and repair, the RNA helicases are classified into superfamilies and families, based on sequence and structural features. Herpes Simplex Virus (HSV) encodes seven proteins essential for the initiation and propagation of viral chromosomal replication. These proteins include an origin-binding protein that also contains helicase activity, a heterodimeric DNA polymerase, a single-stranded (ss)DNA-binding protein and a heterotrimeric helicase-primase. BAY 57-1293 (Axon 2266) is a potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections and was found to be superior compared to all compounds currently used to treat HSV infections.

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More About Helicase-Primase

Nearly all aspects of RNA metabolism, from transcription and translation to mRNA decay, involve RNA helicases, which are enzymes that use ATP to bind or remodel RNA and DNA and their protein complexes (e.g. ribonucleoprotein (RNP) complexes). RNA helicases are found in all three domains of life, and many viruses also encode one or more of these proteins. Together with the structurally related DNA helicases that function in replication, recombination and repair, the RNA helicases are classified into superfamilies and families, based on sequence and structural features. Herpes Simplex Virus (HSV) encodes seven proteins essential for the initiation and propagation of viral chromosomal replication. These proteins include an origin-binding protein that also contains helicase activity, a heterodimeric DNA polymerase, a single-stranded (ss)DNA-binding protein and a heterotrimeric helicase-primase[1]. BAY 57-1293 (Axon 2266) is a potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections and was found to be superior compared to all compounds currently used to treat HSV infections[2].

[1] J.J. Crute et al. Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease. Nat. Med. 2002, 8, 386- 391.
[2] U.A. Betz et al. Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293. Antimicrob. Agents Chemother. 2002, 46, 1766-1772.

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