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BRM/BRG1 ATP Inhibitor-1
Axon 4434
CAS:
2270879-17-7
Purity:
99%
- Soluble in DMSO
- MF: C11H9F3N4O2S
- MW: 318.28
Description
BRM/BRG1 ATP Inhibitor-1 is a potent, orally active allosteric dual BRM and BRG1 inhibitor with an IC50 value of <5 nM for BRM. BRM/BRG1 ATP Inhibitor-1 downregulates BRM-dependent gene expression and shows antiproliferative activity in a BRG1-mutant-lung-tumor xenograft model upon oral administration.
More Information
| Parent CAS No. | 2270879-17-7 |
|---|---|
| Chemical Name | (4-(3-(3-(Difluoromethyl)-5-isothiazolyl)ureido)-6-fluoro-3-pyridyl)methanol |
| SMILES | C1(F)=CC(NC(=O)NC2SN=C(C(F)F)C=2)=C(CO)C=N1 |
| MFCD | MFCD32067923 |
| InChi | InChI=1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20) |
| InChiKey | CKYCAIAVJIFWPE-UHFFFAOYSA-N |
| CID | 137701967 |
| Short Description | BRM/BRG1 inhibitor |
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