VVD-214
- RO7589831
Axon 4271
CAS:
3026500-20-6
- Optical Purity: 98% e.e.
- Soluble in DMSO
- MF: C20H21F2N3O4S
- MW: 437.46
Description
VVD214 is a potent, selective, allosteric inhibitor of WRN helicase (Werner syndrome ATP-dependent helicase). It covalently engages cysteine 727 of WRN in a nucleotide cooperative manner and inhibits ATP hydrolysis and helicase activity.
More Information
| Parent CAS No. | 3026500-20-6 |
|---|---|
| Chemical Name | (S,E)-N-(1-Cyclopropyl-3-(methylsulfonyl)allyl)-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(C(F)(F)C)N=C(OC2C=CC=CC=2)C(C(=O)N[C@@H](C2CC2)/C=C/S(C)(=O)=O)=CN=1 |&1:18,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | WRN helicase inhibitor |
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