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eIF4A i28
- Soluble in DMSO
- MF: C24H20N2O5
- MW: 416.43
Description
eIF4A i28 is a RNA-competitive, ATP-uncompetitive eIF4A inhibitor with an IC50 of 8.6 μM. eIF4A i28 binds a novel pocket in the RNA groove and inhibits eIF4A with a novel mechanism in which it perturbs RNA binding, blocks the hydrolysis of ATP, and consequently inhibits RNA helicase activity.
More Information
| Parent CAS No. | 2861994-92-3 |
|---|---|
| Chemical Name | 2-(5-(4-Butylphenyl)furan-2-yl)-6-nitroquinoline-4-carboxylic acid |
| MFCD | N.A. |
| Short Description | eIF4A inhibitor |
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