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eIF4A i28

Axon 4120
CAS:  2861994-92-3
Purity:  98%
  • Soluble in DMSO
  • MF:  C24H20N2O5
  • MW:  416.43

Description

eIF4A i28 is a RNA-competitive, ATP-uncompetitive eIF4A inhibitor with an IC50 of 8.6 μM. eIF4A i28 binds a novel pocket in the RNA groove and inhibits eIF4A with a novel mechanism in which it perturbs RNA binding, blocks the hydrolysis of ATP, and consequently inhibits RNA helicase activity.

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