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USP7-USP47 inhibitor
- USP7/47 inhibitor compound 14
- Soluble in DMSO
- MF: C18H11Cl2N3O3S3
- MW: 484.4
Description
USP7-USP47 inhibitor is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47 with IC50 values of 0.42 µM and 1.0 µM for USP7 and USP47, respectively. USP7-USP47 inhibitor exhibited enhanced potency against HCT-116 cells and modestly accelerated the degradation of polβ protein in HeLa cells.
More Information
| Parent CAS No. | 1247825-37-1 |
|---|---|
| Chemical Name | 4-Cyano-5-(3,5-dichloropyridin-4-ylthio)-N-(4-(methylsulfonyl)phenyl)thiophene-2-carboxamide |
| SMILES | C1=C(C(=O)NC2C=CC(S(C)(=O)=O)=CC=2)SC(SC2C(Cl)=CN=CC=2Cl)=C1C#N |
| MFCD | N.A. |
| InChi | InChI=1S/C18H11Cl2N3O3S3/c1-29(25,26)12-4-2-11(3-5-12)23-17(24)15-6-10(7-21)18(27-15)28-16-13(19)8-22-9-14(16)20/h2-6,8-9H,1H3,(H,23,24) |
| InChiKey | GUDJFFQZIISQJB-UHFFFAOYSA-N |
| CID | 51031028 |
| Short Description | USP7 inhibitor |
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