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HBX 41,108
- HBX41108
Axon 3732
CAS:
924296-39-9
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C13H3ClN4O
- MW: 266.64
Description
HBX 41,108 is an inhibitor of USP7/HAUSP ubiquitin protease with an IC50 value of 424 nM. HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. Finally, HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.
More Information
| Parent CAS No. | 924296-39-9 |
|---|---|
| Chemical Name | 7-Chloro-9-oxo-9H-indeno[2,1-b]pyrazine-2,3-dicarbonitrile |
| SMILES | C1C=C2C3N=C(C#N)C(C#N)=NC=3C(=O)C2=CC=1Cl |
| MFCD | MFCD16251537 |
| InChi | InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H |
| InChiKey | BIGPXXAUSQLTQR-UHFFFAOYSA-N |
| CID | 16065773 |
| Short Description | USP7 inhibitor |
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