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Kartogenin

 - KGN
Axon 2378
CAS:  4727-31-5
Purity:  99%
  • Soluble in 0.1N NaOH(aq) and DMSO
  • MF:  C20H15NO3
  • MW:  317.34

Description

Kartogenin is a small-molecule inducer of chondrocyte differentiation from primary human mesenchymal stem cells (MSCs) with an EC50 value of approximately 100 nM. It up-regulates SOX9, collagen II and aggrecan expression and supports cartilage-matrix formation without increasing MMP-3, MMP-13 or aggrecanase expression in reported assays.

Chondrogenic differentiation and extracellular-matrix production are central to cartilage repair and osteoarthritis research. Kartogenin is useful for studying MSC-to-chondrocyte differentiation and regenerative joint biology.

Key Features

  • Promotes chondrocyte differentiation from MSCs
  • EC50: approximately 100 nM
  • Up-regulates SOX9, collagen II and aggrecan
  • Does not increase MMP-3, MMP-13 or aggrecanase expression in reported assays

Applications

  • Cartilage regeneration research
  • MSC differentiation studies
  • Osteoarthritis model assays
  • Extracellular-matrix formation studies

More Information

Parent CAS No. 4727-31-5
Chemical Name 2-(biphenyl-4-ylcarbamoyl)benzoic acid
SMILES C(O)(=O)C1=CC=CC=C1C(NC1=CC=C(C2=CC=CC=C2)C=C1)=O
MFCD N.A.
InChi InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
InChiKey SLUINPGXGFUMLL-UHFFFAOYSA-N
CID 2826191
Short Description Chondrogenesis promotor

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Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

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