In order for cells to function, they must be properly supported, having contacts with neighboring cells and/or the extracellular matrix ECM). The ECM provides much of the structural support available to parenchymal cells in tissues. The primary proteins present in the ECM and indeed the entire body are the collagens, a family of proteins with at least 29 members. They share a common structural motif of helical fibrils formed by three protein subunits. Another cytoplasmic protein, β-Catenin, plays essential roles in two different cellular processes: calcium-dependent intercellular adhesion and Wnt-mediated transcriptional activation. For cell–cell adhesion, β-catenin binds the cytoplasmic domain of cadherin adhesion receptors along with the actin binding protein, α-catenin, to bridge the extracellular adhesive activity of cadherins with the underlying actin cytoskeleton. This cadherin-bound pool of β-catenin ultimately form the so-called adherens junctions and serves to link the cytoskeletal networks of adjacent cells, which is considered essential for normal tissue architecture and morphogenesis,.
Aggregation of extracellular amyloid-β (Aβ) is thought to play a major part in the pathogenesis of Alzheimer's disease. Amyloid plaques form when levels of the monomeric, soluble Aβ peptide build up in the extracellular interstitial fluid (ISF) in the brain. Caprospinol (Axon 1442) has the ability to bind Aβ42, prevent β-amyloid aggregation, and block the formation of Aβ42 oligomers, thereby protecting organisms against β-amyloid (Aβ42)-induced neurotoxicity.
 S.H. Kim, J. Turnbull, S.Guimond. Extracellular matrix and cell signaling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. J. Endocrin. 2011, 209, 139-151.
 F.H. Brembeck, M. Rosário, W. Birchmeier. Balancing cell adhesion and Wnt signaling, the key role of β-catenin. Curr. Opin. Genet. Dev. 2006, 16, 51-59.
 L. Lecanu et al. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience 2010, 165, 427-435.
|Axon ID||Name||Description||From price|
|1442||Caprospinol||Alzheimer's disease therapeutic and antihistaminergic drug||€125.00|
|2161||CCT 031374 hydrobromide||Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway||€60.00|
|1443||Genipin||Protein cross-linker; stimulates insulin secretion||€55.00|
|1766||ICG 001||Specific inhibitor of Wnt/β-catenin signaling pathway||€115.00|
|2135||iCRT14||Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor||€135.00|
|2133||iCRT5||β-Catenin-responsive transcription (CRT) inhibitor||€80.00|
|2378||Kartogenin||Promotor of chondrocyte differentiation from primary human MSCs||€75.00|
|2332||OTX 008||Selective allosteric inhibitor of galectin-1||€125.00|
|2084||SKL 2001||Wnt/β-catenin signaling pathway agonist or activator||€90.00|
|2481||SMT C1100||Orally active, non-toxic upregulator of utrophin production||€125.00|
|2120||Wnt agonist 1||Wnt/β-catenin signaling pathway agonist or activator||€90.00|