Collagen

Collagen

The extracellular matrix of connective tissues represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. Collagen is the major protein of the extracellular matrix (ECM) and is the most abundant protein found in mammals. It acts as a structural scaffold in tissues. The central feature of all collagen molecules is their stiff, triple-stranded helical structure. So far, 26 genetically distinct collagen types have been described. Collagen and collagen-derived fragments control many cellular functions, including cell shape and differentiation, migration, the synthesis of a number of proteins, and it is a key component of a healing wound.

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More About Collagen

The extracellular matrix of connective tissues represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. Collagen is the major protein of the extracellular matrix (ECM) and is the most abundant protein found in mammals. It acts as a structural scaffold in tissues. The central feature of all collagen molecules is their stiff, triple-stranded helical structure. So far, 26 genetically distinct collagen types have been described[1]. Collagen and collagen-derived fragments control many cellular functions, including cell shape and differentiation, migration, the synthesis of a number of proteins, and it is a key component of a healing wound[2].

[1] K. Gelse et al. Collagens--structure, function, and biosynthesis. Adv. Drug Deliv. Rev. 2003, 55, 1531-1546.
[2] D. Brett. A review of collagen and collagen-based wound dressings. Wounds. 2008, 20, 347­353.

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