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Genipin
Axon 1443
CAS:
6902-77-8
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C11H14O5
- MW: 226.23
Description
Genipin is a natural iridoid compound and uncoupling protein 2 inhibitor that reduces UCP2-mediated mitochondrial proton leak and enhances glucose-stimulated insulin secretion.
Genipin increases mitochondrial membrane potential and ATP production in pancreatic β-cells, linking UCP2 inhibition to KATP-channel closure and insulin release. Independently, its reactive aglycone chemistry makes it a widely used protein and biomaterial cross-linker.
Key Features
- Inhibits UCP2-mediated mitochondrial proton leak
- Enhances glucose-stimulated insulin secretion
- Modulates mitochondrial coupling and ATP production
- Natural cross-linker for proteins and biopolymers
Applications
- UCP2 and mitochondrial bioenergetics studies
- Pancreatic β-cell and insulin-secretion research
- Metabolic stress and diabetes models
- Protein, collagen, gelatin and chitosan cross-linking
More Information
| Parent CAS No. | 6902-77-8 |
|---|---|
| Chemical Name | (1R,4aS,7aS)-1-Hydroxy-7-hydroxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester |
| MFCD | MFCD00888600 |
| Short Description | Protein cross-linker |
Genipin
UCP2-mediated mitochondrial proton leak inhibitor
UCP2
UCP2-mediated mitochondrial proton leak
Protein cross-linker
Inhibitor
UCP2 and mitochondrial bioenergetics studies
Pancreatic β-cell and insulin-secretion research
Metabolic stress and diabetes models
Protein and collagen and gelatin and chitosan cross-linking
mitochondrial function
metabolism
diabetes research
enzyme pharmacology
drug discovery
CAS 6902-77-8
Axon Medchem
Axon 1443
Supplier
Vendor
References
- LE Parton et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired by obesity. Nature 2007, 449, 228-233.
- C Zhang et al. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced B cell dysfunction in isolated pancreatic islets. Cell Metab. 2006, 3, 417-427.
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