Wnt-β-Catenin

Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis (embryonic induction, generation of cell polarity, and the specification of cell fate). Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP (low density Lipoprotein Receptor-related Protein) families on the cell surface. The result is alleviation of pathway inhibition caused by GSK-3β, APC, and Axin proteins. This stabilizes β-Catenin and promotes its nuclear translocation where it regulates target gene transcription together with Tcf/Lef proteins. During development, the Wnt/β-catenin pathway integrates signals from many other pathways including Retinoic acid, FGF, TGF-β, and BMP in many different cell-types and tissues. In addition, GSK-3β is also involved in glycogen metabolism and other key pathways, which has made its inhibition relevant to diabetes and neurodegenerative disorders[1],[2].


[1] Wnt signaling and stem cell control. Nusse, R. Cell Research 2008,18, 523-527.
[2] Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors. M. D. Gordon, R. Nusse. J Biol Chem. 2006, 281, 22429-22433.

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Axon ID Name Description From price
1909 A 1070722 Selective inhibitor of GSK-3 €95.00
2167 AR-A 014418 ATP-competitive GSK-3 inhibitor €85.00
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire
5053 Axon Ligands™ Stem cell compound library Axon Ligands™ Stem cell compound library Inquire
2171 AZD 1080 Selective inhibitor of GSK-3α and GSK-3β €110.00
2194 AZD 2858 hydrochloride Potent and highly selective Glycogen Synthase Kinase-3β inhibitor €95.00
1693 BIO GSK-3 inhibitor €95.00
2931 BRD0705 First-in-class, paralog selective GSK3α inhibitor €210.00
3153 BRD5648 Negative control compound of BRD0705 as a GSK3α inhibitor €210.00
3748 C-82 Specific inhibitor of Wnt/β-catenin signaling pathway  Recently added Inquire
2161 CCT 031374 hydrobromide Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway €60.00
1126 CHIR98014 GSK-3 inhibitor €99.00
1386 CHIR99021 GSK-3 inhibitor €60.00
2435 CHIR99021 dihydrochloride GSK-3 inhibitor €60.00
2202 CK2 inhibitor 10 Potent and ATP-competitive inhibitor of CK2 €105.00
3279 CKI-7 dihydrochloride Selective inhibitor of Casein kinase 1 €120.00
1965 CX 4945 hydrochloride Inhibitor of Casein kinase 2 (CK2) €90.00
2574 Defactinib Orally available second generation inhibitor of FAK and PYK2 €80.00
3715 E-7386 CBP/beta-catenin modulator Inquire
2568 EML 425 Potent reversible dual inhibitor of CBP and p300 (HAT/KAT3) €95.00
2686 FH535 Dual inhibitor of PPAR and Wnt/β-catenin signaling €75.00
2706 FH535 sodium salt Dual inhibitor of PPAR and Wnt/β-catenin signaling €80.00
1766 ICG 001 Specific inhibitor of Wnt/β-catenin signaling pathway €115.00
2135 iCRT14 Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor €135.00
2133 iCRT5 β-Catenin-responsive transcription (CRT) inhibitor €80.00
2511 IM 12 GSK-3β inhibitor attenuating neuronal differentiation of human NPCs €95.00
2212 IWP L6 Highly potent porcupine (Porcn) inhibitor €125.00
2510 IWR-1-endo Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2 €85.00
1922 JW 55 Inhibitor of tankyrase (TNKS 1 and 2) €95.00
3557 KPT-9274 Orally bioavailable dual PAK4/NAMPT inhibitor €130.00

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