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H-89 dihydrochloride
Axon 4491
Recently added
- Parent CAS: 1000995-75-4
Purity:
99%
- Soluble in water and DMSO
- MF: C20H20BrN3O2S·2HCl
- MW: 519.28
Description
H-89 dihydrochloride is a potent, cell-permeable, and selective inhibitor of cyclic AMP-dependent protein kinase A (PKA) with a Ki value of 48 nM. It functions as an ATP-competitive inhibitor, often used in research to study PKA-mediated phosphorylation.
More Information
| Parent CAS No. | 1000995-75-4 |
|---|---|
| Chemical Name | 1-(-3-(4-Bromophenyl)-2-propenylamino)-2-(5-isoquinolylsulfonylamino)ethane dihydrochloride |
| SMILES | C1C(S(=O)(=O)NCCNC/C=C/C2C=CC(Br)=CC=2)=C2C=CN=CC2=CC=1.Cl.Cl |
| MFCD | MFCD00214120 |
| InChi | InChI=1/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;; |
| InChiKey | GELOGQJVGPIKAM-WTVBWJGANA-N |
| CID | 5702541 |
| Short Description | PKA inhibitor |
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