Everolimus
- RAD001
- Optical Purity: >99% e.e.
- Soluble in DMSO
- MF: C53H83NO14
- MW: 958.22
Description
Everolimus is a Rapamycin derivative. It is currently used as an immunosuppressant to prevent rejection of organ transplants and as an mTOR inhibitor to treat renal cell cancer and other tumors.
More Information
| Parent CAS No. | 159351-69-6 |
|---|---|
| Chemical Name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1[C@@H](C)[C@]2(O)C(=O)C(=O)N3CCCC[C@H]3C(O[C@@H](CC(=O)[C@H](C)C=C([C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C(C)[C@@H](OC)C[C@@H](O2)C1)C)[C@H](C)C[C@H]1C[C@@H](OC)[C@H](OCCO)CC1)=O |c:42,t:24,38,40,&1:1,3,14,17,21,25,27,32,35,44,48,52,55,57,60,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | mTOR1 inhibitor |
References
- T O'Reilly et al. Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes,Limitations, and Further Proposals. Transl Oncol. 2010 Apr;3(2):65-79.
- T Kawata et al. Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia. Cancer Sci. 2018 Jan;109(1):103-111.
- HA Lane et al. mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin Cancer Res, 2009, 15(5), 1612-1622.
- Y Zhu et al. Antitumor effect of the mTOR inhibitor Everolimus on human breast cancer stem cells in vitro and in vivo. Tumour Biol. 2012 Oct;33(5):1349-6.
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