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PKI 587
- PF 05212384 - Gedatolisib
- Moderately soluble in DMSO
- MF: C32H41N9O4
- MW: 615.73
Description
More Information
| Parent CAS No. | 1197160-78-3 |
|---|---|
| Chemical Name | 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea |
| extra_info | . |
| SMILES | N(C1=CC=C(C(N2CCC(N(C)C)CC2)=O)C=C1)C(NC1=CC=C(C2=NC(N3CCOCC3)=NC(N3CCOCC3)=N2)C=C1)=O |
| MFCD | MFCD16875679 |
| InChi | InChI=1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,43) |
| InChiKey | DWZAEMINVBZMHQ-UHFFFAOYSA-N |
| CID | 44516953 |
| Short Description | PI3K/mTOR inhibitor |
References
- R Mallon et al. Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor. Clin Cancer Res. 2011, 17(10), 3193-203.
- R Gedaly et al. PKI-587 and Sorafenib Targeting PI3K/AKT/mTOR and Ras/Raf/MAPK Pathways Synergistically Inhibit HCC Cell Proliferation. J. Surg. Res. 2011, 1-7.
- AM Venkatesan et al. Bis(morpholino-1,3,5-triazine) derivatives: Potent adenosine 5’-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: Discovery of compound 26 (PKI-587) (...). J. Med. Chem. 2010, 53, 2636.
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