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PI 103 hydrochloride
- Parent CAS: 371935-74-9
- Soluble in DMSO
- MF: C19H16N4O3.HCl
- MW: 384.82
Description
PI 103 hydrochloride is a cell-permeable dual PI3K/mTOR pathway inhibitor that inhibits class I PI3K isoforms, mTOR complexes and DNA-dependent protein kinase.
PI 103 suppresses PIP3–AKT signaling and mTOR-dependent growth control, providing coordinated inhibition of two major nodes in the PI3K pathway. It is commonly used in cancer biology, autophagy and DNA-damage-response studies.
Key Features
- Dual class I PI3K and mTOR pathway inhibitor
- Also inhibits DNA-PK
- Suppresses AKT and mTOR-dependent signaling
- Cell-permeable tool for pathway-interaction studies
Applications
- PI3K–AKT–mTOR signaling research
- Cancer-cell proliferation and survival models
- Autophagy and nutrient-sensing studies
- DNA-PK and DNA-damage-response assays
More Information
| Parent CAS No. | 371935-74-9 |
|---|---|
| Chemical Name | 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-phenol hydrochloride |
| SMILES | C1N=C2OC3C(N4CCOCC4)=NC(C4C=CC=C(O)C=4)=NC=3C2=CC=1.Cl |
| MFCD | MFCD10687102 |
| InChi | InChI=1S/C19H16N4O3.ClH/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23;/h1-6,11,24H,7-10H2;1H |
| InChiKey | XSQMYBFFYPTMFE-UHFFFAOYSA-N |
| CID | 16739368 |
| Short Description | PI3K inhibitor |
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