PI3K

Another significantly large group of kinases that regulate the transfer phosphate groups to hydroxyl groups of substrates is the class of PI3K’s (Phosphatidylinositide 3-kinases, EC 2.7.1.153), a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The family may be divided into three different classes (I-III), based on primary structure, regulation, and in vitro lipid substrate specificity[1]. PI3K’s play a crucial role in the PI3K/AKT/mTOR signaling pathway which is strongly involved in the fundamental cellular processes of protein synthesis and apoptosis. Disturbed activation of this intracellular pathway has been associated with the development of diseases such as cancer, diabetes mellitus, and autoimmunity[2]. Upon activation of phosphatidylinositol (PI)-3-kinase by extracellular growth factors, phosphorylation of the inner membrane phosphoinositides activates AKT (also known as Protein Kinase B, PKB) and PDPK1 (3-phosphoinositide dependent protein kinase-1).


[1] PI3K/Akt/mTOR pathway as a target for cancer therapy. D. Morgensztern, H.L. McLeod Drugs 2005, 16, 797–803
[2] PI3K-Akt pathway: its functions and alterations in human cancer. Osaki M, Oshimura M, Ito H. Apoptosis 2004, 9, 667-676.

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Axon ID Name Description From price
1831 A 66 PI3K inhibitor (p110-α specific) €95.00
1424 AS 252424 PI3K inhibitor (p110-γ specific) €85.00
1436 AS 252424 bispotassium salt PI3K inhibitor (p110-γ specific) €95.00
1282 BAG 956 PI3K and PDPK1 inhibitor €95.00
1281 BEZ 235 PI3K and mTOR tyrosine kinase inhibitor €60.00
2170 CAL 101 PI3K inhibitor (p110 δ specific) €95.00
2039 CZC 24832 PI3K inhibitor (p110-γ specific) €95.00
1719 D 106669 Potent and selective PI3K inhibitor €85.00
1377 GDC 0941 bismesylate PI3K inhibitor €85.00
1782 GDC 0980 Dual PI3K and mTOR inhibitor €105.00
1596 GSK 2126458 Dual PI3K and mTOR inhibitor €80.00
1912 GSK 2636771 dihydrochloride PI3K inhibitor (p110 β specific) €105.00
2168 IC 87114 Potent and highly selective inhibitor of the PI3K p110δ €85.00
1366 LY 294002 PI3K inhibitor €70.00
1520 NVP-BBD130 Dual PI3K and mTOR kinase inhibitor €125.00

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