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PIK 75 hydrochloride
- Parent CAS: 945619-31-8
- Moderately soluble in DMSO
- MF: C16H14BrN5O4S.HCl
- MW: 488.74
Description
PIK 75 hydrochloride is a p110α-selective PI3K inhibitor with reported IC50 values of 7.8 nM for p110α, 343 nM for p110β and 907 nM for p110δ.
PI3K p110α is a central driver of growth factor signaling, insulin response, AKT activation and oncogenic pathway output. PIK 75 is used to study PI3Kα-dependent signaling and isoform selectivity.
Key Features
- Selective PI3K p110α inhibitor
- Reported IC50: 7.8 nM for p110α
- Shows lower potency at p110β and p110δ
- Relevant to AKT, insulin and cancer signaling research
Applications
- PI3K isoform kinase assays
- PI3Kα/AKT pathway studies
- Insulin signaling research
- Cancer cell proliferation and survival models
More Information
| Parent CAS No. | 945619-31-8 |
|---|---|
| Chemical Name | N'-[(1E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride |
| SMILES | C1C=C([N+]([O-])=O)C=C(S(=O)(=O)N(C)/N=C/C2N3C=C(Br)C=CC3=NC=2)C=1C.Cl |
| MFCD | MFCD12546130 |
| InChi | InChI=1S/C16H14BrN5O4S.ClH/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16;/h3-10H,1-2H3;1H/b19-9+; |
| InChiKey | VOUDEIAYNKZQKM-MYHMWQFYSA-N |
| CID | 10275789 |
| Short Description | PI3K p110α inhibitor |
References
- ZA Knight et al. A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling. Cell 2006, 125, 733–747.
- C Chaussade et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007, 404(3), 449–458.
- S Kim et al. Insulin-like growth factor-1 regulates platelet activation through PI3-Kα isoform. Blood, 2007, 110(13), 4206-4213.
- A list of citations for Axon Medchem product Axon 1334 - PIK 75 hydrochloride.
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