List of Publications using PIK 75 (Axon 1334) purchased from Axon Medchem
(Total 15 publication citations listed; updated in JUNE-2016)
2014
Costales, Abran Q., et al. "Compounds and compositions as protein kinase inhibitors." U.S. Patent No. 8,859,548. 14 Oct. 2014.
https://www.google.com/patents/US8859548
*PD0325901, PD184352, SL327, LY294002, PI103, PIK75, PIK90, GDC0941, BEX235, AS252424, TGX221 are from Axon Medchem
https://www.google.com/patents/US8748428
* LY294002, PI103, PIK75, PIK90, AS252424, TGX221, GDC0941 are from Axon Medchem.
http://eurheartj.oxfordjournals.org/content/early/2013/12/09/eurheartj.eht496?rss%253D1=
T Smirnova, ZN Zhou, RJ Flinn, J Wyckoff, PJ Boimel, M Pozzuto, SJ Coniglio, JM Backer, AR Bresnick, JS Condeelis, NE Hynes and JE Segall.
Oncogene 2012, 31, 706-715. | doi:10.1038/onc.2011.275
http://www.nature.com/onc/journal/v31/n6/full/onc2011275a.html
Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.
A Consonni, L Cipolla, G Guidetti, I Canobbio, E Ciraolo, E Hirsch, M Falasca, M Okigaki, C Balduini, M Torti.
Blood 2012, 119(3), 847-856. doi: 10.1182/blood-2011-07-364992
http://bloodjournal.hematologylibrary.org/content/119/3/847.short
The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.
L Cipolla, A Consonni, G Guidetti, I Canobbio, M Okigaki, M Falasca, E Ciraolo, E Hirsch, C Balduini, M Torti.
J. Thromb. Haemost. 2013, 11(2), 345–356. doi: 10.1111/jth.12099
http://www.ncbi.nlm.nih.gov/pubmed/23216754
Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice.
PE Porporato, N Filigheddu, S Reano, M Ferrara, E Angelino, VF Gnocchi, F Prodam, G Ronchi, S Fagoonee, M Fornaro, F Chianale, G Baldanzi, N Surico, F Sinigaglia, I Perroteau, RG Smith, Y Sun, S Geuna, and A Graziani.
J. Clin. Invest. 2013, 123(2), 611–622. doi: 10.1172/JCI39920
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561827/
HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS.
AM Madera, D Poon, A Smith - U.S. Patent 20,130,096,149, issued April 18, 2013.
(10 drugs from Axon Medchem have been tested)
Read more: http://www.freepatentsonline.com/y2013/0096149.html
Compounds and compositions as protein kinase inhibitors.
AQ Costales, S Huang, JX Jin, Z Liu, S Pecchi, D Poon, J Tellew, and Q Zhang.
U.S. Patent 8,242,260, issued August 14, 2012.
HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS.
Madera, Ann Marie, Daniel Poon, and Aaron Smith.
U.S. Patent No. 20,130,096,149. 18 Apr. 2013.
Effects of Isoform-Selective Phosphatidylinositol 3-Kinase Inhibitors on Osteoclasts: ACTIONS ON CYTOSKELETAL ORGANIZATION, SURVIVAL AND RESORPTION.
RPP Shugg, A Thomson, N Tanabe, A Kashishian, BH Steiner, KD Puri, A Pereverzev, BJ Lannutti, FR Jirik, SJ Dixon1 and SM Sims.
J. Biol. Chem. 2013. doi: 10.1074/jbc.M113.507525.
Read more: http://www.jbc.org/content/early/2013/10/16/jbc.M113.507525.short
... GDC0941 bismesylate (1377), TGX221 (1417), AS252424 (1424) and PIK75 (1334) were purchased from Axon MedChem.
Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice.
PE Porporato, N Filigheddu, S Reano, M Ferrara, E Angelino, VF Gnocchi, F Prodam, G Ronchi, S Fagoonee, M Fornaro, F Chianale, G Baldanzi, N Surico, F Sinigaglia, I Perroteau, RG Smith, Y Sun, S Geuna, and A Graziani.
J. Clin. Invest. 2013, 123(2): 611–622. doi: 10.1172/JCI39920. PMCID: PMC3561827
Read more: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561827/
Signaling via Class IA Phosphoinositide 3-Kinases (PI3K) in Human, Breast-Derived Cell Lines.
V Juvin, M Malek, KE Anderson, C Dion, T Chessa, C Lecureuil, GJ Ferguson, S Cosulich, PT Hawkins, LR Stephens.
PLoS ONE 2013, 8(10): e75045. doi:10.1371/journal.pone.0075045
Read more: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0075045
The proline‐rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside‐in signaling.
Cipolla, L., Consonni, A., Guidetti, G., Canobbio, I., Okigaki, M., Falasca, M., ... & Torti, M.
J. Thromb. Haemost. 2013, 11(2), 345-356.
Read more: http://onlinelibrary.wiley.com/doi/10.1111/jth.12099/full
Grape seed proanthocyanidins attenuate vascular smooth muscle cell proliferation via blocking phosphatidylinositol 3-kinase-dependent signaling pathways.
L Wang, LH Zhu, H Jiang, QZ Tang, L Yan, D Wang, C Liu, ZY Bian, H Li.
J. Cell. Physiol. 2010, 223(3), 713–726. DOI: 10.1002/jcp.22080
http://onlinelibrary.wiley.com/doi/10.1002/jcp.22080/abstract
(This is an incomplete list, updated JUNE-2016)
