AAK

Clathrin-mediated endocytosis requires the assembly of a protein coat on the membrane in order to induce curvature and form a spherical invagination. Adaptor-associated kinase 1 (AAK1; EC 2.7.11.1) is a regulatory protein in clathrin-coated vesicle endocytic pathway that phosphorylates the μ subunit of the clathrin-adaptor protein complexes. Evidence has accumulated that AAK1 is involved in the regulation of ALS[1], nociception[2], immunology[3], and Notch signaling[4].


[1] B Shi et al. Dysfunction of endocytic kinase AAK1 in ALS. Int J Mol Sci. 2014 Dec 10;15(12):22918-32.
[2] W Kostich et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.
[3] R Tourdot et al. Clathrin mediated endocytosis and its role in viral entry. Atlas Genet Cytogenet Oncol Haematol. 2013; 17(8), 583-588
[4] N Gupta-Rossi et al. The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. J Biol Chem. 2011 May 27;286(21):18720-30.

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Axon ID Name Description From price
2638 LP-935509 Brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1) €125.00

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