Similar to ATM, the ataxia-telangiectasia and Rad3-related (ATR; EC protein and the DNA-activated protein kinase (DNA-PK) play an important role in responding to agents and extracellular stress that threaten the DNA replication process[1]. Both ATM and ATR kinases lie upstream in the DNA-damage-response signal-transduction network and are central to the entire DNA-damage response; they will be discussed in the corresponding section as well.

Ataxia telangiectasia kinase subclasses: ATM, ATR

[1] ATM,ATR andDNA-PK: initiators of the cellular genotoxic stress responses. J Yang, Y Yu, H Hamrick, PJ Duerksen-Hughes. Carcinogenesis 2003, 24, 1571-1580.

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Axon ID Name Description From price
2345 AZ 20 Potent, orally active and selective inhibitor of ATR protein kinase €105.00
3134 AZD6738 Potent, selective, orally active and bioavailable ATR kinase inhibitor €110.00
2918 BAY 1895344 Potent, orally available and highly selective inhibitor of ATR protein kinase €100.00
1893 VE 821 Inhibitor of the DNA damage response kinase ATR €80.00
2452 VE 822 Selective ATR inhibitor that decreases survival of pancreatic cancer cells €110.00

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