ATR

ATR

Similar to ATM, the ataxia-telangiectasia and Rad3-related (ATR; EC 2.7.11.1) protein and the DNA-activated protein kinase (DNA-PK) play an important role in responding to agents and extracellular stress that threaten the DNA replication process. Both ATM and ATR kinases lie upstream in the DNA-damage-response signal-transduction network and are central to the entire DNA-damage response; they will be discussed in the corresponding section as well.

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More About ATR

Similar to ATM, the ataxia-telangiectasia and Rad3-related (ATR; EC 2.7.11.1) protein and the DNA-activated protein kinase (DNA-PK) play an important role in responding to agents and extracellular stress that threaten the DNA replication process[1]. Both ATM and ATR kinases lie upstream in the DNA-damage-response signal-transduction network and are central to the entire DNA-damage response; they will be discussed in the corresponding section as well.

Ataxia telangiectasia kinase subclasses: ATM, ATR

[1] ATM,ATR andDNA-PK: initiators of the cellular genotoxic stress responses. J Yang, Y Yu, H Hamrick, PJ Duerksen-Hughes. Carcinogenesis 2003, 24, 1571-1580.

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