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VE 821
- Soluble in DMSO
- MF: C18H16N4O3S
- MW: 368.41
Description
VE 821 is a potent and selective ATR kinase inhibitor that disrupts DNA damage response checkpoint signaling.
ATR coordinates replication-stress responses, cell-cycle checkpoint activation and DNA repair following genotoxic stress. VE 821 is used to sensitize tumor cells to radiation or chemotherapeutic DNA damage and to dissect ATR-dependent repair pathways.
Key Features
- Selective ATR inhibitor
- Blocks DNA damage response checkpoint signaling
- Sensitizes tumor cells to radiation and genotoxic drugs
- Useful for replication-stress and DNA repair research
Applications
- ATR pathway and checkpoint kinase studies
- DNA damage response assays
- Radiosensitization and chemosensitization models
- Replication stress and repair pathway research
More Information
| Parent CAS No. | 1232410-49-9 |
|---|---|
| Chemical Name | 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide |
| SMILES | C1(C(NC2=CC=CC=C2)=O)=NC(C2=CC=C(S(C)(=O)=O)C=C2)=CN=C1N |
| MFCD | MFCD19443686 |
| InChi | InChI=1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23) |
| InChiKey | DUIHHZKTCSNTGM-UHFFFAOYSA-N |
| CID | 51000408 |
| Short Description | ATR inhibitor |
References
- PM Reaper et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat. Chem. Biol. 2011, 7(7), 428-430.
- IM Pires et al. Targeting radiation-resistant hypoxic tumour cells through ATR inhibition. Br. J. Cancer. 2012, 107(2), 291-299.
- R Prevo et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol. Ther. 2012, 13, 1072-1081
- List of publications using VE 821 (Axon 1893) purchased from Axon Medchem
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