List of publications using VE 821 (Axon 1893) purchased from Axon Medchem

(Total 45 publication citations; up to date up to June 2023)

Stok, C. (2023). Mitotic processing of DNA replication and repair intermediates in cancer.
* VE-821, veliparib and talazoparib from Axon Medchem

Heijink, A. M., Stok, C., Porubsky, D., Manolika, E. M., de Kanter, J. K., Kok, Y. P., ... & van Vugt, M. A. (2022). Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51. 
Nature Communications, 13(1), 6722.
* Olaparib, Veliparib, talazoparib, B02, VE-821, AZD-1775 from Axon Medchem

Huiting, W., Dekker, S. L., van der Lienden, J. C., Mergener, R., Musskopf, M. K., Furtado, G. V., ... & Bergink, S. (2022). Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome. Elife, 11, e70726.
* VE-821, KU-0058948 and VER-155008 from Axon Medchem

Heijink, A. M., Stok, C., Porubsky, D., Manolika, E. M., Kok, Y. P., Everts, M., ... & van Vugt, M. A. (2021). Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors. Biorxiv, 2021-09.
* Olaparib, Veliparib, talazoparib, B02, VE-821, from Axon Medchem

Sudhindar, P. D., Wainwright, D., Saha, S., Howarth, R., McCain, M., Bury, Y., ... & Shukla, R. (2021). Hcv activates somatic l1 retrotransposition—a potential hepatocarcinogenesis pathway. Cancers, 13(20), 5079.

Sudhindar, P. D., Wainwright, D., Saha, S., Howarth, R., McCain, M., Bury, Y., ... & Shukla, R. (2021). HCV Activates Somatic L1 Retrotransposition to Influence Hepatocarcinogenesis Beyond Viral Clearance. 

Permata, T. B. M., Sato, H., Gu, W., Kakoti, S., Uchihara, Y., Yoshimatsu, Y., ... & Shibata, A. (2021). High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells. 
Journal of radiation research, 62(5), 773-781.

Sharma, V. K., Islam, S., Borkar, J., Mishra, S., Panda, D., Santra, M. K., & Lahiri, M. (2021). ATR facilitates the degradation of Api5 through the ubiquitin-proteasome pathway via FBXW2 to regulate apoptosis upon DNA damage. 
bioRxiv, 2021-08.

Ninou, A. H., Lehto, J., Chioureas, D., Stigsdotter, H., Schelzig, K., Åkerlund, E., ... & Gustafsson, N. M. S. (2021). PFKFB3 inhibition sensitizes DNA crosslinking chemotherapies by suppressing Fanconi anemia repair. 
Cancers, 13(14), 3604.
Fujii, A., Sunatani, Y., Furuichi, K., Fujimoto, K., Adachi, H., Iwabuchi, K., & Yokoyama, H. (2020). DNA damage in human glomerular endothelial cells induces nodular glomerulosclerosis via an ATR and ANXA2 pathway. Scientific Reports, 10(1), 1-12.

佐藤浩央. (2020). 137. がん免疫応答を制御する DNA 修復応答の解明.

Warmerdam, D. O., Alonso‐de Vega, I., Wiegant, W. W., van den Broek, B., Rother, M. B., Wolthuis, R. M., ... & Smits, V. A. (2020). PHF6 promotes non‐homologous end joining and G2 checkpoint recovery. EMBO reports, 21(1).

Landsverk, H. B., Sandquist, L. E., Sridhara, S. C., Rødland, G. E., Sabino, J. C., de Almeida, S. F., ... & Syljuåsen, R. G. (2019). Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1. Nucleic acids research, 47(4), 1797-1813.

Mengwasser, K. E., Adeyemi, R. O., Leng, Y., Choi, M. Y., Clairmont, C., D’Andrea, A. D., & Elledge, S. J. (2019). Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Molecular cell, 73(5), 885-899.

Permata, T. B. M., Hagiwara, Y., Sato, H., Yasuhara, T., Oike, T., Gondhowiardjo, S., ... & Shibata, A. (2019). Base excision repair regulates PD-L1 expression in cancer cells. Oncogene, 1.
Gustafsson, N. M., Färnegårdh, K., Bonagas, N., Ninou, A. H., Groth, P., Wiita, E., ... & Martinsson, J. (2018). Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nature communications, 9(1), 3872.

Fordham, S. E., Blair, H. J., Elstob, C. J., Plummer, R., Drew, Y., Curtin, N. J., ... & Pollard, J. (2018). Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase. Blood Advances, 2(10), 1157-1169.
Landsverk, H. B., Sandquist, L. E., Rodland, G. E., Grallert, B., Trinkle-Mulcahy, L., & Syljuasen, R. G. (2018). Regulation of ATR activity by the RNA polymerase II phosphatase PNUTS-PP1. bioRxiv, 267013.
Bøe, C. A., Håland, T. W., Boye, E., Syljuåsen, R. G., & Grallert, B. (2018). A novel role for ATR/Rad3 in G1 phase. Scientific reports, 8(1), 6880.
Henriksson, S., Groth, P., Gustafsson, N., & Helleday, T. (2018). Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation. Cell Cycle, 1-12.
Halim, V. A., García-Santisteban, I., Warmerdam, D. O., van den Broek, B., Heck, A. J., Mohammed, S., & Medema, R. H. (2018). Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation. Molecular & Cellular Proteomics, mcp-RA118.
Payne, E. H., Ramalingam, D., Fox, D. T., & Klotman, M. E. (2018). Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells. Journal of virology, 92(2), e01718-17.
Sato, H., Niimi, A., Yasuhara, T., Permata, T. B. M., Hagiwara, Y., Isono, M., ... & Yoshimoto, Y. (2017). DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells. Nature communications, 8(1), 1751.
Coucoravas, C., Dhanjal, S., Henriksson, S., Böhm, S., & Farnebo, M. (2017). Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response. RNA biology, 14(6), 804-813.
Nakajima, N. I., Niimi, A., Isono, M., Oike, T., Sato, H., Nakano, T., & Shibata, A. (2017). Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells. Oncology Reports, 38(2), 693-702.
Feng, Y. L., Xiang, J. F., Liu, S. C., Guo, T., Yan, G. F., Feng, Y., ... & Cai, X. J. (2017). H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions. Nucleic Acids Research.
Muralidharan, S. V., Einarsdottir, B. O., Bhadury, J., Lindberg, M. F., Wu, J., Campeau, E., ... & Nilsson, J. A. (2017). BET bromodomain inhibitors synergize with ATR inhibitors in melanoma in melanoma. Cell Death and Disease, 8(8), e2982; doi:10.1038/cddis.2017.383.
Sun, B., Ross, S. M., Rowley, S., Adeleye, Y., & Clewell, R. A. (2017). Contribution of ATM and ATR kinase pathways to p53‐mediated response in etoposide and methyl methanesulfonate induced DNA damage. Environmental and molecular mutagenesis, 58(2), 72-83.
Cheung, R. S., Castella, M., Abeyta, A., Gafken, P. R., Tucker, N., & Taniguchi, T. (2017). Ubiquitination-Linked Phosphorylation of the FANCI S/TQ Cluster Contributes to Activation of the Fanconi Anemia I/D2 Complex. Cell reports, 19(12), 2432-2440.
Coucoravas, C., Dhanjal, S., Henriksson, S., Böhm, S., & Farnebo, M. (2017). Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response. RNA biology, 14(6), 804-813.
Muralidharan, S. V., Bhadury, J., Nilsson, L. M., Green, L. C., McLure, K. G., & Nilsson, J. A. (2016). BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. Oncogene, 35(36), 4689-4697.
(* AZ20 and VE821 from Axon Medchem)
New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress. 
Ercilla, A., Llopis, A., Feu, S., Aranda, S., Ernfors, P., Freire, R., & Agell, N. (2016). 
Nucleic acids research, gkw132.
Targeting Myc-driven tumours-BETing on ATR.
Veppil Muralidharan, Somsundar. Thesis. (2016).
*AZ20 and VE821 from Axon Medchem
VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation.
H Fujisawa, NI Nakajima, S Sunada, Y Lee, H Hirakawa, H Yajima, A Fujimori, M Uesaka and R Okayasu.
Radiation Oncology, 2015,10, 175.

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2.
M Castella, C Jacquemont, EL Thompson, JE Yeo, RS Cheung, JW Huang, A Sobeck, EA Hendrickson, T Taniguchi.
PLoS Genet 2015, 11, e1005563. 

RNA Polymerase III Regulates Cytosolic RNA: DNA Hybrids and Intracellular MicroRNA Expression. 
CX Koo, K Kobiyama, YJ Shen, N LeBert, S Ahmad, M Khatoo, T Aoshi, S Gasser and KJ Ishii.
J. Biol. Chem, 2015, 290, 7463-7473.

Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells.
YJ Shen, N Le Bert, AA Chitre1, CX Koo, XH Nga, SSW Ho, M Khatoo, NY Tan, KJ Ishii, S Gasser.
Cell Reports, 2015, 11 (3), 460–473. doi:10.1016/j.celrep.2015.03.041

The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. 
S Henriksson, H Rassoolzadeh, E Hedström, C Coucoravas, A Julner, M Goldstein, G Imreh, B Zhivotovsky, MB Kastan, T Helleday and M Farnebo.
Genes & Dev. 2014. 28: 2726-2738. doi: 10.1101/gad.246546.114

N-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells.
S Bodakuntla, S Sural, P Trivedi, M Lahiri. 
BMC cancer, 2014, 14(1), 287.

The Role of Base Excision Repair and Mismatch Repair Proteins in the Processing of Cisplatin Interstrand Cross-Links.
Akshada Sawant, 2014 
PhD Thesis, The University of Toledo.

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
KVM Huber, E Salah, B Radic, M Gridling, JM Elkins, A Stukalov, AS Jemth, C Göktürk, K Sanjiv, K Strömberg, T Pham, U Berglund, J Colinge, KL Bennett, JI Loizou, T Helleday, S Knapp & G Superti-Furga.
Nature 2014, 508, 222–227. | doi:10.1038/nature13194

RAE-1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma.
AR Lam, N Le Bert, SSW Ho, YJ Shen, LFM Tang, GM Xiong, JL Croxford, CX Koo, KJ Ishii, S Akira, DH Raulet, S Gasser.
Cancer Res. 2014, 74(8), 2193-2203.  | doi: 10.1158/0008-5472

Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation. 
AN Zelensky, H Sanchez, D Ristic, I Vidic, SE van Rossum-Fikkert, J Essers, C Wyman and R Kanaar.
Nucl. Acids Res. 2013, 41 (13), 6475-6489. | doi: 10.1093/nar/gkt375

Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells.
E Rass, G Chandramouly, S Zha, FW Alt and A Xie.
J. Biol. Chem. 2013, 288, 7086-7095. | doi: 10.1074/jbc.M112.445825

An Inverse Switch in DNA Base Excision and StrandBreak Repair Contributes to Melphalan Resistance in Multiple Myeloma Cells
MML Sousa, KA Zub, PA Aas, A Hanssen-Bauer, A Demirovic, A Sarno, E Tian, NB Liabakk, G Slupphaug.
PLoS ONE 2013, 8(2), e55493. | doi:10.1371/journal.pone.0055493

(This is an incomplete list, updated AUGUST 2017)

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