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VE 821
- Soluble in DMSO
- MF: C18H16N4O3S
- MW: 368.41
Description
Potent and selective inhibitor of the DNA damage response (DDR) kinase ATR. which sensitises tumour cells to DNA damage induced by radiation or chemotoxic drugs, by disrupting the DNA damage checkpoint and inhibiting DNA repair.
More Information
| Parent CAS No. | 1232410-49-9 |
|---|---|
| Chemical Name | 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide |
| SMILES | C1(C(NC2=CC=CC=C2)=O)=NC(C2=CC=C(S(C)(=O)=O)C=C2)=CN=C1N |
| MFCD | MFCD19443686 |
| InChi | InChI=1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23) |
| InChiKey | DUIHHZKTCSNTGM-UHFFFAOYSA-N |
| CID | 51000408 |
| Short Description | ATR inhibitor |
References
- PM Reaper et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat. Chem. Biol. 2011, 7(7), 428-430.
- IM Pires et al. Targeting radiation-resistant hypoxic tumour cells through ATR inhibition. Br. J. Cancer. 2012, 107(2), 291-299.
- R Prevo et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol. Ther. 2012, 13, 1072-1081
- List of publications using VE 821 (Axon 1893) purchased from Axon Medchem
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