Order

Size
Price
Stock
Qty

Special Offers

Size
Price
Stock
Qty

VE 822

 - Berzosertib  - VX 970
Axon 2452
CAS:  1232416-25-9
Purity:  99%
  • Soluble in 0.1N HCl(aq) and DMSO
  • MF:  C24H25N5O3S
  • MW:  463.55

Description

Selective ATR inhibitor (IC50 values 0.019 µM, 2.6 µM, and 18.1 µM for ATR, ATM, and DNA-PK, respectively) with in vitro and in vivo activity that decreases maintenance of cell-cycle checkpoints and homologous recombination in irradiated cancer cells, and increases persistent DNA damage. VE822 decreased survival of pancreatic cancer cells but not normal cells in response to XRT or gemcitabine.

More Information

Certificate of Analysis

Material Safety Data Sheet

Parent CAS No. 1232416-25-9
Chemical Name 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine
SMILES C1(N)=NC=C(C2=CC=C(S(C(C)C)(=O)=O)C=C2)N=C1C1ON=C(C2=CC=C(CNC)C=C2)C=1
MFCD N.A.
InChi InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)
InChiKey JZCWLJDSIRUGIN-UHFFFAOYSA-N
CID 59472121
Short Description ATR inhibitor

Related Products

AXON ID NAME FROM PRICE
1281 BEZ 235

From $55.00

1282 BAG 956

From $104.50

1334 PIK 75 hydrochloride

From $77.00

1362 PIK 90

From $93.50

1366 LY 294002

From $77.00

1367 KU-55933

From $121.00

1377 GDC 0941 bismesylate

From $88.00

1380 PI 103 hydrochloride

From $66.00

1417 TGX 221

From $77.00

1424 AS 252424

From $93.50

1436 AS 252424 bispotassium salt

From $104.50

1463 NU 7441

From $44.00

1495 CP 466722

From $77.00

1520 NVP-BBD130

From $137.50

1596 GSK 2126458

From $55.00

1706 XL PI3K/mTOR inhibitor

From $132.00

1719 D 106669

From $93.50

1782 GDC 0980

From $88.00

1797 NVP-BKM120

From $99.00

1807 PKI 587

From $99.00

1831 A 66

From $104.50

1855 PF 04691502

From $99.00

1893 VE 821

From $88.00

1912 GSK 2636771 dihydrochloride

From $115.50

Loading...