IRAK

IRAK

The interleukin-1 receptor-associated kinase (IRAK) family mediates activating signal from TLRs and interleukin-1 receptor. The family comprises of four members, IRAK1, IRAK2, IRAK-M, IRAK4. The family members have a role in either positive or negative regulation of innate immunity, adaptive immunity and inflammation. Accumulated evidence proves that IRAK performs significantly in the pathogenesis of inflammatory autoimmune disorders. Moreover, mounting evidence implicates these kinases as viable cancer targets.

Read More
sort-descending
  • HS-243
    3217
    HS-243
    The price depends on the options chosen on the product page

    From $99.00

  • GLPG2534
    3917
    GLPG2534
    The price depends on the options chosen on the product page

    From $165.00

  • IRAK1/4 inhibitor 1
    4235
    IRAK1/4 inhibitor 1
    The price depends on the options chosen on the product page

    From $132.00

3 Items

More About IRAK

The interleukin-1 receptor-associated kinase (IRAK) family mediates activating signal from TLRs and interleukin-1 receptor. The family comprises of four members, IRAK1, IRAK2, IRAK-M, IRAK4. The family members have a role in either positive or negative regulation of innate immunity, adaptive immunity and inflammation. Accumulated evidence proves that IRAK performs significantly in the pathogenesis of inflammatory autoimmune disorders.[1] Moreover, mounting evidence implicates these kinases as viable cancer targets.[2]

[1] LC Su et al. IRAK family in inflammatory autoimmune diseases. Autoimmun Rev. 2020 Mar;19(3):102461.
[2] GW Rhyasen et al. IRAK signalling in cancer. Br J Cancer. 2015 Jan 20;112(2):232-7.

Loading...