SRPK

Serine-arginine protein kinases (SPRKs; EC 2.7.11.1) constitute a relatively novel subfamily of serine-threonine kinases that specifically phosphorylate serine residues residing in serine-arginine/arginine-serine dipeptide motifs. Originally considered to be devoted to constitutive and alternative mRNA splicing, SRPKs are now known to expand their influence to additional steps of mRNA maturation, as well as to other cellular activities, such as chromatin reorganization in somatic and sperm cells, cell cycle and p53 regulation, and metabolic signaling[1].


[1] T. Giannakouros et al. Serine-arginine protein kinases: a small protein kinase family with a large cellular presence. FEBS J. 2011, 278, 570-586.

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Axon ID Name Description From price
2714 SPHINX31 Potent and selective inhibitor of SRPK1 kinase activity  Recently added €125.00
2200 SRPIN 340 Selective ATP competitive inhibitor of SRPK kinase activity €95.00

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