Bulk Inquiry
SPHINX31
Axon 2714
CAS:
1818389-84-2
Purity:
99%
- Soluble in DMSO
- MF: C27H24F3N5O2
- MW: 507.51
Description
SPHINX31 is a highly potent, selective, and cell active SRPK1 inhibitor (IC50 value of 6 nM). Treatment with this inhibitor inhibited SRPK1 activity and phosphorylation of serine/arginine splicing factor 1 (SRSF1), resulting in alternative splicing of VEGF-A from pro-angiogenic to antiangiogenic isoforms. This property resulted in potent inhibition of blood vessel growth in models of choroidal angiogenesis in vivo.
More Information
| Parent CAS No. | 1818389-84-2 |
|---|---|
| Chemical Name | N-(2-(4-(Pyridin-2-ylmethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide |
| SMILES | C1C(C(F)(F)F)=CC(NC(=O)C2=CC=C(C3C=CN=CC=3)O2)=C(N2CCN(CC3N=CC=CC=3)CC2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36) |
| InChiKey | VURLRACCOCGFDB-UHFFFAOYSA-N |
| CID | 91972002 |
| Short Description | SRPK1 inhibitor |
Other Categories
Get a Quote for
Loading...