PKD

PKD

Protein kinase D (PKD; EC 2.7.11.13) consists of a small family of three members (PKD1-3) of ubiquitous serine-threonine protein kinases that are involved in the regulation of various functions within the cell, including cell proliferation, apoptosis, adhesion, and cell motility. PKD1 was initially recognized as a member of the protein kinase C (PKC) family and named PKCμ. However, distinct differences in the protein structure, variation in substrate(s) and inhibitor specificity, and low homology of the kinase domain to other members of the PKC family resulted in its reclassification. PKD1 is now classified as a member of the protein kinase D (PKD) family, a distinct branch under the calcium/calmodulin-dependent protein kinase. Studies revealed that the mechanism of PKD activation is mediated not only by DAG, but also, directly or indirectly, through PKCs.

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    CID 755673
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More About PKD

Protein kinase D (PKD; EC 2.7.11.13) consists of a small family of three members (PKD1-3) of ubiquitous serine-threonine protein kinases that are involved in the regulation of various functions within the cell, including cell proliferation, apoptosis, adhesion, and cell motility. PKD1 was initially recognized as a member of the protein kinase C (PKC) family and named PKCμ. However, distinct differences in the protein structure, variation in substrate(s) and inhibitor specificity, and low homology of the kinase domain to other members of the PKC family resulted in its reclassification. PKD1 is now classified as a member of the protein kinase D (PKD) family, a distinct branch under the calcium/calmodulin-dependent protein kinase[1]. Studies revealed that the mechanism of PKD activation is mediated not only by DAG, but also, directly or indirectly, through PKCs[2].

AGC kinases listed: PKA, PKC, PKD

[1] Emerging Roles of Protein Kinase D1 in Cancer. V.Sundram,S.C. Chauhan, M. Jaggi. Mol. Cancer Res. 2011, 9, 985-996.
[2] Protein Kinase D Signaling. E. Rozengurt, O. Rey, R.T. Waldron. J. Biol. Chem. 2005, 280, 13205-13208.

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