DCLK

Doublecortin like kinase protein 1 (Dclk1) is a microtubule-associated protein with a C-terminal serine/threonine kinase domain. Originally designated Doublecortin and CaM kinase-like 1 protein (Dcamkl1) or KIAA0369, Dclk1 was first described as a marker for radial glia cells in the context of microtubule polymerization and neuronal migration, possibly contributing to early neurogenesis. Additionally, Dclk1 was proposed as a marker of quiescent gastrointestinal and pancreatic stem cells, but in recent years has been recognized as a marker for tuft cells in the gastrointestinal tract[1]. Dclk1 overexpression has been reported in multiple human cancers, including colorectal cancer and gastric cancer[2].


[1] CB Westphalen et al. Functional implication of Dclk1 and Dclk1-expressing cells in cancer. Small GTPases. 2017 Jul 3;8(3):164-171.
[2] FM Ferguson et al. Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 Jun;16(6):635-643.

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Axon ID Name Description From price
3200 DCLK1-IN-1 Potent, selective and orally bioavailable DCLK1/2 inhibitor €140.00

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