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Necrostatin-1
- Nec-1
Axon 1258
CAS:
4311-88-0
Purity:
99%
- Soluble in DMSO
- MF: C13H13N3OS
- MW: 259.33
Description
Necrostatin-1 is a cell-permeable, potent and selective necroptosis inhibitor that acts as an ATP-competitive inhibitor of RIPK1 kinase.
RIPK1 is a central regulator of necroptotic cell death and inflammatory signaling. Necrostatin-1 is a key tool for distinguishing RIPK1-dependent necroptosis from apoptosis and other cell death pathways.
Key Features
- Cell-permeable necroptosis inhibitor
- ATP-competitive RIPK1 kinase inhibition
- Negligible effect reported on RIPK2 kinase activity
- Reference compound for programmed necrosis research
Applications
- RIPK1 kinase inhibition assays
- Necroptosis and cell death pathway studies
- Inflammation and tissue injury models
- Apoptosis versus necroptosis discrimination
More Information
| Parent CAS No. | 4311-88-0 |
|---|---|
| Chemical Name | 5-((1H-indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one |
| SMILES | C1C=C2C(CC3C(=O)N(C)C(=S)N3)=CNC2=CC=1 |
| MFCD | MFCD00056916 |
| InChi | InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18) |
| InChiKey | TXUWMXQFNYDOEZ-UHFFFAOYSA-N |
| CID | 2828334 |
| Short Description | RIP1 inhibitor |
Necrostatin-1
necroptosis inhibitor
Nec-1
RIP1
RIPK1
RIPK2
necroptosis
Inhibitor
RIPK1 kinase inhibition assays
Necroptosis and cell death pathway studies
Inflammation and tissue injury models
Apoptosis versus necroptosis discrimination
apoptosis
inflammation
kinase signaling
receptor selectivity
signal transduction
CAS 4311-88-0
Axon Medchem
Axon 1258
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