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JNK-IN-8
- JNK Inhibitor XVI
Axon 2361
CAS:
1410880-22-6
Purity:
98%
- Soluble in DMSO
- MF: C29H29N7O2
- MW: 507.59
Description
Remarkably potent and selective covalent inhibitor of JNK (IC50 values 4.67 nM, 18.7 nM, and 0.98nM for JNK1/2/3, respectively). JNK-IN-8 inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue (EC50 values 486 nM and 338 nM for inhibition of c-Jun phosphorylation in HeLa and A375 cells, respectively).
Useful as a pharmacological probe of JNK-dependent signal transduction
More Information
| Parent CAS No. | 1410880-22-6 |
|---|---|
| Chemical Name | 3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide |
| SMILES | C1(NC(=O)/C=C/CN(C)C)C=C(C(NC2C=CC(NC3N=C(C4C=CC=NC=4)C=CN=3)=C(C)C=2)=O)C=CC=1 |
| MFCD | MFCD22124890 |
| InChi | InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ |
| InChiKey | GJFCSAPFHAXMSF-UXBLZVDNSA-N |
| CID | 57340686 |
| Short Description | JNK inhibitor |
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