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GNE-3511
- Soluble in DMSO
- MF: C23H26F2N6O
- MW: 440.49
Description
GNE-3511 is a potent, selective, orally bioavailable and brain-penetrant DLK inhibitor with a Ki value of <0.0005 μM, giving an IC50 value of 0.030 μM for pJNK inhibition. GNE-3511 displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease.
More Information
| Parent CAS No. | 1496581-76-0 |
|---|---|
| Chemical Name | 2-(6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-ylamino)isonicotinonitrile |
| SMILES | C1C(NC2N=CC=C(C#N)C=2)=NC(N2CC(F)(F)CC2)=CC=1C1CCN(C2COC2)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H26F2N6O/c24-23(25)4-8-31(15-23)22-11-18(17-2-6-30(7-3-17)19-13-32-14-19)10-21(29-22)28-20-9-16(12-26)1-5-27-20/h1,5,9-11,17,19H,2-4,6-8,13-15H2,(H,27,28,29) |
| InChiKey | RHFIAUKMKYHHFA-UHFFFAOYSA-N |
| CID | 72547959 |
| Short Description | DLK inhibitor |
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