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CC-401
Axon 2025
CAS:
395104-30-0
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C22H24N6O
- MW: 388.47
Description
CC-401 is a second-generation, ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor. It inhibits stress-activated MAPK signaling with relevance to inflammatory, apoptotic and oncology-associated pathways.
JNK kinases integrate cytokine, oxidative stress and genotoxic stress signals to regulate transcription, apoptosis and tissue injury responses. CC-401 is useful for studying MAPK/JNK pathway pharmacology in inflammation, fibrosis and cancer models.
Key Features
- ATP-competitive JNK inhibitor
- Targets stress-activated MAPK signaling
- Relevant to apoptosis and inflammatory response pathways
- Useful second-generation JNK pharmacology tool
Applications
- JNK kinase assays
- MAPK stress-signaling studies
- Inflammation and fibrosis models
- Cancer cell survival pathway research
More Information
| Parent CAS No. | 395104-30-0 |
|---|---|
| Chemical Name | 3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole |
| SMILES | N1C2=C(C=C(C3NN=CN=3)C=C2)C(C2=CC=CC(OCCN3CCCCC3)=C2)=N1 |
| MFCD | MFCD16038646 |
| InChi | InChI=1S/C22H24N6O/c1-2-9-28(10-3-1)11-12-29-18-6-4-5-16(13-18)21-19-14-17(22-23-15-24-27-22)7-8-20(19)25-26-21/h4-8,13-15H,1-3,9-12H2,(H,25,26)(H,23,24,27) |
| InChiKey | XDJCLCLBSGGNKS-UHFFFAOYSA-N |
| CID | 10430360 |
| Short Description | JNK inhibitor |
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