List of publications using PD 0325901 (Axon 1408) purchased from Axon Medchem 

(Total 107 publication citations listed; updated in May 2016)

Takemoto, Noriaki, et al. "Gtsf1l and Gtsf2 Are Specifically Expressed in Gonocytes and Spermatids but Are Not Essential for Spermatogenesis." PloS one 11.3 (2016): e0150390.
2i:CHIR99021 and PD0325901 from Axon Medchem

Meek, Stephen, et al. "Reduced levels of dopamine and altered metabolism in brains ofHPRTknock-out rats: a new rodent model of Lesch-Nyhan Disease." Scientific reports 6 (2016): 25592.

Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., ... & Izsvák, Z. (2016). Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression. Nature Protocols, 11(2), 327-346.
2i:CHIR99021 and PD0325901 from Axon Medchem 

Haagensen, Emma J., et al. "Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent." European Journal of Cancer 56 (2016): 69-76.

Nairismägi, M. L., et al. "JAK-STATand G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma." Leukemia (2016).
PD0325901, GSK 1120212 and ZD 1839 from Axon Medchem

Sudheer, Smita, et al. "Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT‐Induced Presomitic Mesoderm."STEMCELLS (2016).
2i:CHIR99021 and PD0325901 from Axon Medchem

Carbognin, Elena, et al. "Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency." The EMBO journal (2016): e201592629.
2i:CHIR99021 and PD0325901 from Axon Medchem

 Sancho-Martinez, Ignacio, et al. "Establishment of human iPSC-based models for the study and targeting of glioma initiating cells." Nature communications 7 (2016).
2i:CHIR99021 and PD0325901 from Axon Medchem

Kawano, Haruna, et al. "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." Oncology reports 34.5 (2015): 2251-2258.
2i:CHIR99021 and PD0325901 from Axon Medchem

Perini, Ilaria, et al. "Myogenic induction of adult and pluripotent stem cells using recombinant proteins." Biochemical and biophysical research communications 464.3 (2015): 755-761.
2i:CHIR99021 and PD0325901 from Axon Medchem

Murayama, Hideyuki, et al. "Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin." Stem cell reports 4.1 (2015): 103-113.
2i:CHIR99021 and PD0325901 from Axon Medchem

Iseki, Hiroyoshi, et al. "Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells."STEMCELLS (2015).
2i:CHIR99021 and PD0325901 from Axon Medchem

Yanagida, Ayaka, et al. "Liver maturation deficiency in p57Kip2−/− mice occurs in a hepatocytic p57 Kip2 expression-independent manner."  Developmental biology 407.2 (2015): 331-343.
2i:CHIR99021 and PD0325901 from Axon Medchem

Huijbers, I. J., Del Bravo, J., Ali, R. B., Pritchard, C., Braumuller, T. M., van Miltenburg, M. H., ... & Jonkers, J. (2015). Using the GEMM-ESCstrategy to study gene function in mouse models. Nature protocols, 10(11), 1755-1785.
2i:CHIR99021 and PD0325901 from Axon Medchem

Lieske, Nora V., et al. "Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors." PloS one 10.11 (2015): e0141903.
2i: PD0325901 from Axon Medchem

Kawakami, Eri, et al. "The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators." Mechanisms of development 135 (2015): 31-42.
2i:CHIR99021 and PD0325901 from Axon Medchem

Kamiya, Akihide, et al. "MEK-ERK Activity Regulates the Proliferative Activity of Fetal Hepatoblasts Through Accumulation of p16/19cdkn2a." Stem cells and development 24.21 (2015): 2525-2535.
2i:CHIR99021 and PD0325901 from Axon Medchem

Welling, Maaike, et al. "DAZL regulates Tet1 translation in murine embryonic stem cells." EMBO reports 16.7 (2015): 791-802.

Tabata, Yoshikuni, et al. "Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells." Journal of Biomolecular Screening 20.9 (2015): 1074-1083.
*CHIR99021, PD0325901 and LDN193189 from Axon Medchem

piggyBac Transposon-Based Insertional Mutagenesis in Mouse Haploid Embryonic Stem Cells.
Pettitt, S. J., Tan, E. P., & Yusa, K. (2015).
Methods Mol Biol. 2015;1239:15-28. doi: 10.1007/978-1-4939-1862-1_2.
2i: CHIR99021 and PD0325901 from Axon Medchem

DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes.
Cohen, I. S., Bar, C., Paz-Elizur, T., Ainbinder, E., Leopold, K., de Wind, N., ... & Livneh, Z.
Nucleic acids research, 2015, 43(3), 1637-1645.
2i: CHIR99021 and PD0325901 from Axon Medchem

Establishment of Tsc2‑deficient rat embryonic stem cells.
Ito, Y., Kawano, H., Kanai, F., Nakamura, E., Tada, N., Takai, S., ... & Hino, O.
International journal of oncology, 2015, 46(5), 1944-1952.
2i: CHIR99021 and PD0325901 from Axon Medchem

Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.
Yang, J., Wang, W., Ooi, J., Campos, L. S., Lu, L., & Liu, P.
Stem Cells. 2015 May;33(5):1390-404. doi: 10.1002/stem.1926.
2i: CHIR99021 and PD0325901 from Axon Medchem

Establishment and Use of Mouse Haploid ES Cells.
Leeb, M., Perry, A. C., & Wutz, A.
Current Protocols in Mouse Biology, 2015, 155-185.
2i: CHIR99021 and PD0325901 from Axon Medchem

Embryonic stem cell differentiation requires full length Chd1.
Piatti, P., Lim, C. Y., Nat, R., Villunger, A., Geley, S., Shue, Y. T., ... & Lusser, A.
Sci Rep. 2015 Jan 26;5:8007. doi: 10.1038/srep08007.
2i: CHIR99021 and PD0325901 from Axon Medchem

Functional Compensation Between Myc and PI3K Signaling Supports Self‐Renewal of Embryonic Stem Cells.
Hishida, T., Nakachi, Y., Mizuno, Y., Katano, M., Okazaki, Y., Ema, M., ... & Okuda, A.
Stem Cells, 2015, 33(3), 713-725.
2i: CHIR99021 and PD0325901 from Axon Medchem

Phospho-STIM1 is a downstream effector that mediates the signaling triggered by IGF-1 in HEK293 cells.
Tomas-Martin, P., Lopez-Guerrero, A. M., Casas-Rua, V., Pozo-Guisado, E., & Martin-Romero, F. J.
Cellular signalling, 2015, 27(3), 545-554.

STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration.
Casas-Rua, V., Tomas-Martin, P., Lopez-Guerrero, A. M., Alvarez, I. S., Pozo-Guisado, E., & Martin-Romero, F. J.
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2015, 1853(1), 233-243.

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.
Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, et al.
PLoS Genet 11(5): e1005239. doi:10.1371/journal.pgen.1005239
*3i: SB431542, CHIR99021 and PD0325901 from Axon Medchem

Funktionelle Analyse der Histon-Demethylase UTX in hämatopoetisch differenzierenden murinen ES-Zellen.
Kampka, J. (2015).
Doctoral dissertation of Julius-Maximilians-Universität Würzburg.
2i: CHIR99021 and PD0325901 from Axon Medchem

2014 (total 23 citations)
Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation.
de Esch, C. E., Ghazvini, M., Loos, F., Schelling-Kazaryan, N., Widagdo, W., Munshi, S. T., ... & Willemsen.
Stem Cell Reports. 2014, 3, 548–555.
* PD0325901 (1μM, ERK1/2i, Axon 1408); CHIR99021 (3μM, GSK3i, Axon 1386); SB203580 (10 μM, p38i, Axon 1363) Y-27632 (5μM, Axon 1683) from Axon Medchem.

Pharmacological suppression of the Ras/MAPK pathway in thyroid carcinoma cells can provoke opposite effects on cell migration and proliferation: The appearance of yin-yang effects and the need of combinatorial treatments.
Glassmann, A., Winter, J., Kraus, D., Veit, N., & Probstmeier, R.
International journal of oncology, 2014, 45(6), 2587-2595. 

Erk Signaling Suppresses Embryonic Stem Cell SelfRenewal to Specify Endoderm.
Hamilton, W. B., & Brickman, J. M.
Cell report, 2014, 9(6), 2056–2070.
2i: CHIR99021 and PD0325901 from Axon Medchem

A conserved role for non-neural ectoderm cells in early neural development.
Cajal, M., Creuzet, S. E., Papanayotou, C., Sabéran-Djoneidi, D., de Sousa Lopes, S. M. C., Zwijsen, A., ... & Camus, A.
Development, 2014, 141(21), 4127-4138. 

Compounds and compositions as protein kinase inhibitors.
Costales, A. Q., Huang, S., Jin, J. X., Liu, Z., Pecchi, S., Poon, D., ... & Zhang, Q. (2014).
U.S. Patent No. 8,859,548.
*PD0325901 and other 11 drugs from Axon Medchem, including PD184352, SL327, LY294002, PI103, PIK75, PIK90, GDC0941, BEZ235, AS252424 and TGX221.

Gene Targeting Study Reveals Unexpected Expression of Brain expressed X-linked 2 in Endocrine and Tissue Stem/progenitor Cells in Mice.
K Ito, S Yamazaki, R Yamamoto, Y Tajima, A Yanagida, T Kobayashi, M Kato-Itoh, S Kakuta, Y Iwakura, H Nakauchi and A Kamiya*.
J Biol Chem. 2014 Oct 24;289(43):29892-911. doi: 10.1074/jbc.M114.580084.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) were procured from Axon Medchem.  

JC Clevers, T Sato, M Huch Ortega, W Richard.
US Patent Application 20140243227.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) are procured from Axon Medchem  

Identifying Nuclear Protein–Protein Interactions Using GFP Affinity Purification and SILAC-Based Quantitative Mass Spectrometry.
HI Baymaz, CG Spruijt, M Vermeulen.
Methods in Molecular Biology 2014, 1188, 207-226.
2i inhibitors (Axon Medchem, CHIR99021 and PD0325901)  

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer.
AR Palla, D Piazzolla, M Abad, H Li, O Dominguez, HB Schonthaler, EF Wagner and M Serrano.
Oncogene 2014, 33, 2513–2519.
2i: CHIR99021 and PD0325901 from Axon Medchem  

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.
D Piazzolla, AR Palla, C Pantoja, M Cañamero… & M Serrano*.
Nat Commun. 2014 Jun 30;5:4226. doi: 10.1038/ncomms5226.
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) are procured from Axon Medchem.  

Homologous Recombination Efficiency Enhanced by Inhibition of MEK and GSK3β.
Z Lin, Y Zhang, T Gao, L Wang, Q Zhang, J Zhou, J Zhao.
Genesis, 2014, in press. DOI: 10.1002/dvg.22821

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation.
U Müller, C Bauer, M Siegl, A Rottach, H Leonhardt*
Nucleic Acids Res. 2014 Jul;42(13):8592-604. doi: 10.1093/nar/gku552. 
2i: PD0325901 (Axon 1408) and CHIR99021 (Axon 1386) 

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
T Pfaffeneder, F Spada, M Wagner, C Brandmayr, SK Laube, D Eisen, M Truss, J Steinbacher, ....
Nat Chem Biol. 2014 Jul;10(7):574-81. doi: 10.1038/nchembio.1532.

Citrullination regulates pluripotency and histone H1 binding to chromatin.
MA Christophorou, G Castelo-Branco, RP Halley-Stott, CS Oliveira, R Loos, A Radzisheuskaya, KA Mowen, P Bertone, JCR Silva, M Zernicka-Goetz, ML Nielsen, JB Gurdon & T Kouzarides.
Nature 507, 104–108 (06 March 2014) doi:10.1038/nature12942
*both PD0325901 and CHIR99021 from Axon Medchem

Formation of a Polarised Primitive Endoderm Layer in Embryoid Bodies Requires Fgfr/Erk Signalling.
G Doughton, J Wei, N Tapon, MJ Welham, AD Chalmers.
PLOS ONE, 2014, 9(4): e95434. doi:10.1371/journal.pone.0095434

FIREWACh: High-throughput Functional Detection of Transcriptional Regulatory Modules in Mammalian Cells.
M Murtha, Z Tokcaer-Keskin, Z Tang, F Strino, X Chen, Y Wang, X Xi, C Basilico, S Brown, R Bonneau, Y Kluger, and L Dailey.
Nat Methods. 2014 May;11(5):559-65. doi: 10.1038/nmeth.2885.
*2i, PD0325901, 1 μM and CHIR99021, 3 μM from Axon Medchem 

T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signaling responses.
SS. Skånland, K Moltu, T Berge, EM Aandahl and K Taskén
Biochem J. 2014 Jun 15;460(3):399-410. doi: 10.1042/BJ20140040.

Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells.
IJ Huijbers, RB Ali, C Pritchard, M Cozijnsen, MCh Kwon, N Proost, JY Song, H de Vries, J Badhai, K Sutherland, P Krimpenfort, EM Michalak, J Jonkers, A Berns.
EMBO J. 2014, online. DOI: 10.1002/emmm.201303297 | Published 08.01.2014.
2i, PD0325901 and CHIR99021 from Axon Medchem

Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
D Smeets, Y Markaki, VJ Schmid, F Kraus, Anna Tattermusch, A Cerase, M Sterr, S Fiedler, J Demmerle, J Popken, H Leonhardt, N Brockdorff, T Cremer, L Schermelleh, and M Cremer.
Epigenetics & Chromatin 2014, 7, 8.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

Rapid identification of targeted transgene integrations in ES cells by fluorescence detection.
S Kautschitsch, L Andersen, S Hammerschmid, & T Rülicke.
Transgenic Res. 2014 Jun;23(3):469-75. doi: 10.1007/s11248-014-9782-3.
*2i (MEK inhibitor PD0325901, 1 μM and GSK3 inhibitor CHIR99021, 3 μM) from Axon Medchem 

T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signaling responses.
SS Skånland, K Moltu, T Berge, EM Aandahl and K Taskén.
Biochem J. 2014 Jun 15;460(3):399-410. doi: 10.1042/BJ20140040.

Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells.
I Ismailoglu, Q Chen, M Popowski, L Yang, SS Gross, AH Brivanlou.
Dev Biol. 2014 Jul 15;391(2):230-40. doi: 10.1016/j.ydbio.2014.04.005.

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.
Masouleh, B. K., Geng, H., Hurtz, C., Chan, L. N., Logan, A. C., Chang, M. S., ... & Müschen, M.
Proceedings of the National Academy of Sciences, 2014, 111(21), E2219-E2228. doi: 10.1073/pnas.1400958111
*STF-083010, AZD5363 and PD325901 were obtained from Axon Medchem

2013 (*23 publications in 2013)
Derivation of novel human ground state naive pluripotent stem cells.
O Gafni, L Weinberger, AA Mansour, YS Manor, E Chomsky, D Ben-Yosef, Y Kalma, S Viukov, ...& JH Hanna.
Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. 
*CHIR99021 (Axon 1386), PD0325901 (Axon 1408), SB202190 (Axon 1364), BIRB796 (Axon 1358), Y-27632 (Axon 1683) used in this study are procured from Axon Medchem. 

Identification of Ccr4-Not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
M Kamon, M Katano, K Hiraki-Kamon, T Hishida, Y Nakachi, Y Mizuno, Y Okazaki, A Suzuki, M Hirasaki, A Ueda, M Nishimoto, H Kato, and A Okuda.
Stem Cells Dev. 2014 Sep 15;23(18):2170-9. doi: 10.1089/scd.2013.0326.

Deterministic direct reprogramming of somatic cells to pluripotency. 
Y Rais, A Zviran, S Geula, O Gafni, E Chomsky, S Viukov, AA Mansour, I Caspi, V Krupalnik, ....& JH Hanna. 
Nature, 2013, 502 (7469), 65-70.

Targeting and tracing of specific DNA sequences with dTALEs in living cells. 
Thanisch, K., Schneider, K., Morbitzer, R., Solovei, I., Lahaye, T., Bultmann, S., & Leonhardt, H. 
Nucleic Acids Res. 2014 Apr;42(6):e38. doi: 10.1093/nar/gkt1348.
2i: PD0325901 and CHIR99021 from Axon Medchem

Inhibition of Stim1 Phosphorylation Underlies Resveratrol-Induced Inhibition of Store-Operated Calcium Entry.
V Casas-Rua, IS Álvarez, E Pozo-Guisado, FJ Martín-Romero.
Biochem Pharmacol. 2013 Dec 1;86(11):1555-63. doi: 10.1016/j.bcp.2013.09.018. 

The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.
A Kumar, T Torii, Y Ishino, D Muraoka, T Yoshimura, A Togayachi, H Narimatsu, K Ikenaka and S Hitoshi.
J Biol Chem. 2013 Oct 4;288(40):28859-68. doi: 10.1074/jbc.M113.469403.

PDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
J Tan, Z Li, PL Lee, P Guan, MY Aau, ST Lee, M Feng, CZ Lim, EYJ Lee, ZN Wee, YC Lim, RKM Karuturi and Q Yu.
Cancer Discov. 2013 Oct;3(10):1156-71. doi: 10.1158/2159-8290.CD-12-0595. 
... 60 inhibitors including PD0325901 were purchased from Axon Medchem 

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer
AR Palla, D Piazzolla, M Abad, H Li, O Dominguez, HB Schonthaler, EF Wagner and M Serrano.
Oncogene. 2014 May 8;33(19):2513-9. doi: 10.1038/onc.2013.196.

Tuning of β‐catenin Activity is Required to Stabilise Self‐renewal of Rat Embryonic Stem Cells.
S Meek, J Wei, L Sutherland, B Nilges, M Buehr, SR Tomlinson, AJ Thomson, T Burdon.
Stem Cells. 2013 Oct;31(10):2104-15. doi: 10.1002/stem.1466.

Epigenetic regulation of lentiviral and retroviral vectors in murine embryonic stem (ES) cells and genetic modification of ES cells with lentiviral vectors for application in regenerative medicine.
TT LIM, 2013
PhD Thesis. Universitäts-und Landesbibliothek Bonn. (supervisors: A Pfeifer and DO Fürst)

Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules.
N Liu, M Wang, W Deng, CS Schmidt, W Qin, H Leonhardt, F Spada.
PLoS ONE 2013, 8(5): e62755. doi:10.1371/journal.pone.0062755

Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog.
V Karwacki-Neisius, J Göke, R Osorno, F Halbritter, JH Ng, AY Weiße, FCK Wong, A Gagliardi, NP Mullin, N Festuccia, D Colby, SR Tomlinson, HH Ng, I Chambers.
Cell Stem Cell 2013, 12(5), 531-545.

ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem Cells, but Is Not Required for Multi-Lineage Commitment.
WB Hamilton, K Kaji, T Kunath.
PLoS ONE 2013, 8(4): e60907. doi:10.1371/journal.pone.0060907

Essential role of Sox2 for the establishment and maintenance of the germ cell line.
F Campolo, M Gori, R Favaro, S Nicolis, M Pellegrini, F Botti, P Rossi, EA Jannini, S Dolci.
Stem Cells. 2013 Jul;31(7):1408-21. doi: 10.1002/stem.1392.

AM Madera, D Poon, A Smith
U.S. Patent 20,130,096,149, issued April 18, 2013.
10 drugs from Axon Medchem have been cited

Tcf15 Primes Pluripotent Cells for Differentiation.
OR Davies, CY Lin, A Radzisheuskaya, X Zhou, J Taube, G Blin, A Waterhouse, AJH Smith, S Lowell.
Cell Reports 2013, 3(2), 472-484.

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal.
Y Sanchez-Ripoll, HK Bone, T Owen, AMV Guedes, E Abranches, B Kumpfmueller, RV Spriggs, D Henrique, MJ Welham.
PLoS ONE 2013, 8(4), e60148. doi:10.1371/journal.pone.0060148

LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP.
T Hochdörfer, C Tiedje, DJ Stumpo, PJ Blackshear, M Gaestel, M Huber.
Cell Signal. 2013, 25(6), 1339–1347.

Efficient Generation of Rat Induced Pluripotent Stem Cells Using a Non-Viral Inducible Vector.
C Merkl, A Saalfrank, N Riesen, R Kühn, A Pertek, S Eser, MS Hardt, A Kind, D Saur, W Wurst, A. Iglesias, A Schnieke.
PLoS ONE 2013, 8(1): e55170. doi:10.1371/journal.pone.0055170

Deep proteome coverage based on ribosome profiling aids MS-based protein and peptide discovery and provides evidence of alternative translation products and near-cognate translation initiation events.
G Menschaert, W Van Criekinge, T Notelaers, A Koch, J Crappe, K Gevaert and P Van Damme.
Mol Cell Proteomics. 2013 Jul;12(7):1780-90. doi: 10.1074/mcp.M113.027540. 

BRAF mutations in chronic lymphocytic leukemia.
BMC Jebaraj, D Kienle, A Bühler, D Winkler, H Döhner, S Stilgenbauer & T Zenz.
Leukemia & lymphoma, 2013, 54(6), 1177-1182.

Derivation of porcine induced pluripotent stem cells and somatic cells gene targeting in pig.
Xinxin Cu (2013) PhD thesis.
TECHNISCHE UNIVERSITÄT MÜNCHEN, Lehrstuhl für Biotechnologie der Nutztiere.
2i: PD0325901 and CHIR99021 from Axon Medchem

Liver organoid, uses thereof and culture method for obtaining them
MH Ortega, JC Clevers.
US 20130189327 A1

(33 publications from 2010 till 2012; *This is an imcomplete list extracted from 64 citations)
Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry.
E Pozo-Guisado, DG Campbell, M Deak, A. Álvarez-Barrientos, NA Morrice, IS Álvarez, DR Alessi, and FJ Martín-Romero*
J. Cell Sci. 2010, 123 (18), 3084-3093.
(... PD184352 and PD0325901 from Axon Medchem...) 

Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells.
MY Chang, D Kim, CH Kim, HC Kang, E Yang, et al.
PLoS ONE 2010, 5(3): e9838.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Generation of genetically modified rats from embryonic stem cells.
Masaki Kawamata and Takahiro Ochiya
PNAS 2010, 107 (32), 14223-14228.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Neural induction intermediates exhibit distinct roles of Fgf signaling.
J Sterneckert, M Stehling, C Bernemann, MJ Araúzo-Bravo, B Greber, L Gentile, C Ortmeier, M Sinn, G Wu, D Ruau, M Zenke, R Brintrup, DC Klein, K Ko, HR Schöler.
STEM CELLS 2010, 28 (10), 1772-1781. 

A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.
K Horie, C Kokubu, J Yoshida, K Akagi, A Isotani, A Oshitani, K Yusa, R Ikeda, Y Huang, A Bradley & J Takeda.
Nature Methods 2011, 8, 1071-1077. doi:10.1038/nmeth.1739
... Serum-free medium containing 2i (MEK inhibitor PD0325901 (Axon Medchem) plus GSK3 inhibitor CHIR99021 (Axon Medchem)) was prepared and used in phenotypic analyses. 

FGF signalling inhibits neural induction in human embryonic stem cells.
B Greber, P Coulon, M Zhang, S Moritz, S Frank, AJ Müller-Molina, MJ Araúzo-Bravo, DW Han, HC Pape and HR Schöler.
EMBO J. 2011, 30, 4874-4884. 

Distinct Developmental Ground States of Epiblast Stem Cell Lines Determine Different Pluripotency Features.
C Bernemann, B Greber, K Ko, J Sterneckert, DW Han, MJ Araúzo-Bravo, HR Schöler*
Stem Cells 2011, 29 (10), 1496-1503.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Rat Embryonic Stem Cell Derivation and Propagation.
Ping Li, Eric N. Schulze, Chang Tong and Qi-Long Ying.
ADVANCED PROTOCOLS FOR ANIMAL TRANSGENESIS. Springer Protocols Handbooks, 2011, 457-475, DOI: 10.1007/978-3-642-20792-1_19
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.
A Isotani, H Hatayama, K Kaseda, M Ikawa, M Okabe*.
Genes to Cells 2011, 16 (4), 397–405.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Loss of Dnd1 facilitates the cultivation of genital ridge-derived rat embryonic germ cells.
E Northrup, R Eisenblätter, S Glage, C Rudolph, M Dorsch, B Schlegelberger, HJ Hedrich, NH Zschemisch.
Exp. Cell Res. 2011, 317 (13), 1885–1894.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

T Cell-Signaling Network Analysis Reveals Distinct Differences between CD28 and CD2 Costimulation Responses in Various Subsets and in the MAPK Pathway …
ME Kalland, NG Oberprieler, T Vang, K Taskén and KM Torgersen.
J. Immunol. 2011, 187 (10), 10 5233-5245 

US Patent Application 20110283374.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Effect of Small Molecule Supplements during In Vitro Culture of Mouse Zygotes and Parthenogenetic Embryos on Hypoblast Formation and Stem Cell Derivation.
K. Versieren, M. Van der Jeught, T. O’Leary, G. Duggal, J. Gerris, S. Chuva de Sousa Lopes, B. Heindryckx and P. De Sutter.
STEM CELL REVIEWS AND REPORTS 2012, DOI: 10.1007/s12015-012-9382-7
(Axon 1386 - CHIR 99021 was also tested in this paper) 

In vitro expansion and functional recovery of mature hepatocytes from mouse adult liver.
H Ito, A Kamiya*, K Ito, A Yanagida, K Okada, H Nakauchi*
Liver International 2012, 32 (4), 592-601.  doi: 10.1111/j.1478-3231.2011.02741.x
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Identification of Rat Rosa26 Locus Enables Generation of Knock-in Rat Lines Ubiquitously Expressing tdTomato.
T Kobayashi, M Kato-Itoh, T Yamaguchi, C Tamura, M Sanbo, M Hirabayashi, and H Nakauchi.
Stem Cells and Development. 2012, 21(16): 2981-2986.  doi:10.1089/scd.2012.0065.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Kinetics and activation requirements of contact-dependent immune suppression by human regulatory T cells.
KW Brudvik, BA Bjørnbeth, A Foss, K Taskén and EM Aandahl.
J Immunol. 2012, 188 (11), 5459-5466.
... Imatinib mesylate, CP 690550, and PD 0325901 were purchased from Axon Medchem ... 

The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
R Korhonen, N Huotari, T Hömmö, T Leppänen, E Moilanen.
Mol. Immunol. 2012, 51 (2), 219–226. 

Sirt1, p53 and p38MAPK are Crucial Regulators of Detrimental Phenotypes of ESCs with Max Expression Ablation.
T Hishida, Y Nozaki, Y Nakachi, Y Mizuno…
STEM CELLS, 2012, 30(8), 1634–1644. DOI: 10.1002/stem.1147 

Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells.
AD Egorova, K Van der Heiden, S Vd Pas, P Vennemann, C Poelma, MC DeRuiter, MJTH Goumans, AC Gittenberger-de Groot, P ten Dijke, RE Poelmann, BP Hierck.
Devel. Dynamics 2011, 240 (7), 1670–1680. 

MEK/Erk-based negative feedback mechanism involved in control of Steel Factor-triggered production of Krüppel-like factor 2 in mast cells.
JS Marschall, T Wilhelm, W Schuh, M Huber.
Cell. Signal. 2012, 24 (4), 879–888.
(...  PD0325901 as well as PD184352 from axon Medchem ...) 

Dynamic interaction networks in a hierarchically organized tissue
DC Kirouac, C Ito, E Csaszar, A Roch… - Molecular systems …, 2010 -
Mol. Systems Biol. 2012, 6, 417  doi:10.1038/msb.2010.71
(... LY294002, Degulin, U73122, BAY439006, and PD0325901 were purchased from Axon Medchem ...) 

Small Molecule-Assisted, Line-Independent Maintenance of Human Pluripotent Stem Cells in Defined Conditions.
S Frank, M Zhang, HR Schöler, B Greber.
PLoS ONE 2012, 7(7): e41958. doi:10.1371/journal.pone.0041958

Two distinct knockout approaches highlight a critical role for p53 in rat development.
M Kawamata & T Ochiya. - -
Scientific Reports 2012, 2, 945. doi:10.1038/srep00945

Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development.
K Okada, A Kamiya, K Ito, A Yanagida, H Ito, H Kondou, H Nishina, and H Nakauchi.
Stem Cells and Development. 2012, 21(7): 1124-1133. doi:10.1089/scd.2011.0229.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) were procured from Axon Medchem.

T Ochiya, M Kawamata - European Patent EP 2508595, issued October 10, 2012. 

T Ishikawa, K Hagiwara, and T Ochiya.
European Patent EP 2532741, issued December 12, 2012. 

Novel method for rapid and efficient generation of neuroectoderm cells and peripheral neurons from pluripotent stem cells.
B Greber, and H Schöler.
European Patent EP 2497825, issued September 12, 2012. 

Compounds and compositions as protein kinase inhibitors.
AQ Costales, S Huang, JX Jin, Z Liu, S Pecchi, D Poon, J Tellew, and Q Zhang.
U.S. Patent 8,242,260, issued August 14, 2012. 

* Many investigators in stem cell research often use CHIR 99021 (Axon 1386) and PD0325901 (Axon 1408) together as 2i.

See publications used CHIR 99021 from Axon Medchem

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