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Axon 1408 - Publications

List of publications using PD0325901 (Axon 1408) purchased from Axon Medchem 

(Total 429 publication citations listed; updated up to December 2022)
 
2023 (35 citations)
Alonso-Alonso, S., Esteve-Codina, A., Martin-Mur, B., Álvarez-González, L., Ruiz-Herrera, A., Santaló, J., & Ibáñez, E. (2023). Blastomeres of 8-cell mouse embryos differ in their ability to generate embryonic stem cells and produce lines with different transcriptional signatures. Frontiers in cell and developmental biology, 11, 1274660.
Higashitani, Y., & Horie, K. (2023). Long-read sequence analysis of MMEJ-mediated CRISPR genome editing reveals complex on-target vector insertions that may escape standard PCR-based quality control. Scientific Reports, 13(1), 11652.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Oldak, B., Wildschutz, E., Bondarenko, V., & Hanna, J. H. (2023). Generation of bona fide fully integrated human post-implantation structured embryo models (SEM) derived ex utero solely from genetically unmodified naïve (HENSM) pluripotent stem cells.
* 7i from Axon Medchem, incl GO6983, PD0325901, CGP77675, Y27632, BIR796, A83-01 and CHIR99021.

Fabyanic, E. B., Hu, P., Qiu, Q., Berríos, K. N., Connolly, D. R., Wang, T., ... & Wu, H. (2023). Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects. Nature Biotechnology, 1-15.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Cheng, L., De, C., Li, J., & Pertsinidis, A. (2023). Mechanisms of transcription control by distal enhancers from high-resolution single-gene imaging. BioRxiv.
Kaemena, D. F., Yoshihara, M., Beniazza, M., Ashmore, J., Zhao, S., Bertenstam, M., ... & Kaji, K. (2023). B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors. Nature Communications, 14(1), 488.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Wilhelm, T., Toledo, M. A., Simons, I., Stuth, C., Mohta, V., Mülfarth, R., ... & Huber, M. (2023). Capitalizing on paradoxical activation of the mitogen‐activated protein kinase pathway for treatment of Imatinib‐resistant mast cell leukemia. Hematological Oncology, 41(3), 520-534.
van der Veer, B. K., Chen, L., Custers, C., Athanasouli, P., Schroiff, M., Cornelis, R., ... & Koh, K. P. (2023). Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation. Nucleic Acids Research, 51(11), 5469-5498.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Bernardini, A., Mukherjee, P., Scheer, E., Kamenova, I., Antonova, S., Mendoza Sanchez, P. K., ... & Tora, L. (2023). Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID. Nature Structural & Molecular Biology, 30(8), 1141-1152.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Noviello, G., Gjaltema, R. A., & Schulz, E. G. (2023). CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Nature Communications, 14(1), 3225.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Alfeghaly, C., Castel, G., Cazottes, E., Moscatelli, M., Moinard, E., Casanova, M., ... & Rougeulle, C. (2023). XIST dampens X chromosome activity in a SPEN-dependent manner during early human development. bioRxiv, 2023-10.
https://www.biorxiv.org/content/10.1101/2023.10.19.563078v1.full

Sinenko, S. A., Kuzmin, A. A., Skvortsova, E. V., Ponomartsev, S. V., Efimova, E. V., Bader, M., ... & Tomilin, A. N. (2023). Tryptophan hydroxylase-2-mediated serotonin biosynthesis suppresses cell reprogramming into pluripotent state. International Journal of Molecular Sciences, 24(5), 4862.
 * 2i: CHIR99021 and PD0325901 from Axon Medchem

Coppiello, G., Barlabe, P., Moya-Jódar, M., Abizanda, G., Pogontke, C., Barreda, C., ... & Aranguren, X. L. (2023). Generation of heart and vascular system in rodents by blastocyst complementation. Developmental Cell, 58(24), 2881-2895.
 * 2i: CHIR99021 and PD0325901 from Axon Medchem

Schüle, K. M., Weckerle, J., Probst, S., Wehmeyer, A. E., Zissel, L., Schröder, C. M., ... & Arnold, S. J. (2023). Eomes restricts Brachyury functions at the onset of mouse gastrulation. Developmental Cell, 58(18), 1627-1642.
https://www.sciencedirect.com/science/article/abs/pii/S1534580723003969?via%3Dihub
 * 2i: CHIR99021 and PD0325901 from Axon Medchem

Schmidt, C., Deyett, A., Ilmer, T., Haendeler, S., Caballero, A. T., Novatchkova, M., ... & Mendjan, S. (2023). Multi-chamber cardioids unravel human heart development and cardiac defects. Cell, 186(25), 5587-5605.
https://www.cell.com/cell/pdf/S0092-8674(23)01181-9.pdf

Knudsen, T. E., Hamilton, W. B., Proks, M., Lykkegaard, M., Linneberg-Agerholm, M., Nielsen, A. V., ... & Brickman, J. M. (2023). A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation. Cell Systems, 14(9), 788-805.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Arboit, M., Zorzan, I., Pellegrini, M., Martini, P., Carbognin, E., & Martello, G. (2023). KLF7 is a general inducer of human pluripotency. bioRxiv, 2023-09.
* 7i: PD0325901, Y27632, XAV939, GO6983, CHIR99021, A83-01, SB432541 from Axon Medchem

Oldak, B., Wildschutz, E., Bondarenko, V., Comar, M. Y., Zhao, C., Aguilera-Castrejon, A., ... & Hanna, J. H. (2023). Complete human day 14 post-implantation embryo models from naive ES cells. Nature, 622(7983), 562-573.
* 7i from Axon Medchem, incl GO6983, PD0325901, CGP77675, Y27632, BIR796, A83-01 and CHIR99021.

Ugur, E. (2023). Porte,. de la. Qin, WH, Bultmann, S., I ano a,., Drukker, ME,… Leonhardt, H.
* 2i : PD0325901 and CHIR99021 from Axon Medchem.

Ferlazzo, G. M., Gambetta, A. M., Amato, S., Cannizzaro, N., Angiolillo, S., Arboit, M., ... & Martello, G. (2023). Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity. Nature Communications, 14(1), 3962.
* 4i from Axon MedChem, including CHIR99021, PD0325901, SB431542 and Y27632

Correia, B., Sousa, M. I., & Ramalho-Santos, J. (2023). Metabolic Effects on Mouse Embryonic Stem Cells and the Canonical Mammalian Target of Rapamycin Pathway. BioChem, 3(4), 170-181.
* 2i: PD0325901 and CHIR99021 from Axon MedChem

Carbognin, E., Carlini, V., Panariello, F., Chieregato, M., Guerzoni, E., Benvegnù, D., ... & Martello, G. (2023). Esrrb guides naive pluripotent cells through the formative transcriptional programme. Nature cell biology, 25(5), 643-657.
* 4i from Axon MedChem, including PD0325901, CHIR99021, XAV939 and Y27632.

Trapannone, R., Romanov, J., & Martens, S. (2023). p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons. Life Science Alliance, 6(11).
* 2i : PD0325901 and CHIR99021 from Axon Medchem

Meek, S., Singh-Dolt, K., Sutherland, L., Sharp, M. G., Del-Pozo, J., Walker, D., & Burdon, T. (2023). p75NTR neurotrophin receptor function is redundant for development, growth and fertility in the rat. bioRxiv, 2023-12.
* 2i : CHIR99021 and PD0325901 from Axon Medchem

Aizawa, E., Ozonov, E. A., Kawamura, Y. K., Dumeau, C. E., Nagaoka, S., Kitajima, T. S., ... & Wutz, A. (2023). Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes. The EMBO Journal, 42(23), e113955.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Fujimori, T., Rios-Martinez, C., Thurm, A. R., Hinks, M. M., Doughty, B. R., Sinha, J., ... & Bintu, L. (2023). Single-cell chromatin state transitions during epigenetic memory formation. bioRxiv.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Mulas, C., Stammers, M., Salomaa, S. I., Heinzen, C., Suter, D. M., Smith, A., & Chalut, K. J. (2023). ERK signalling orchestrates metachronous transition from naive to formative pluripotency. bioRxiv, 2023-07.
* CHIR99021, PD0325901 and BI-D1870 from Axon Medchem

Krishna, A., Meynert, A., Kelder, M., Ewing, A., Sheraz, S., Ferrer-Vacquer, A., ... & Ozdemir, D. D. (2023). Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits. bioRxiv, 2023-11.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Etxaniz Díaz de Durana, J. (2023). A Comparative Study Of Cell Culture Conditions During Conversion From Primed To Naive Human Pluripotent Stem Cells.
* CHIR99021, PD0325901, SP600125, BIRB796, Y-27632, GO6983 from Axon Medchem

Iwatsuki, K., Oikawa, M., Kobayashi, H., Penfold, C. A., Sanbo, M., Yamamoto, T., ... & Kobayashi, T. (2023). Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells. Cell Reports Methods, 3(8).
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Dinarello, A., Betto, R. M., Diamante, L., Tesoriere, A., Ghirardo, R., Cioccarelli, C., ... & Argenton, F. (2023). STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia. Cell Death Discovery, 9(1), 226.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Yayli, G., Bernardini, A., Sanchez, P. K. M., Scheer, E., Damilot, M., Essabri, K., ... & Tora, L. (2023). ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct. Cell reports, 42(9).
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Argenton, F., Martello, G., Tiso, N., Dinarello, A., Betto, R., Meneghetti, G., ... & Tesoriere, A. (2023). STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia.
* 2i : CHIR99021 + Pd0325901 from Axon Medchem

Alonso Alonso, S. Análisis del potencial de los blastómeros del embrión de ratón a 8 células para generar células madre embrionarias.
* 2i : CHIR99021 + Pd0325901 from Axon Medchem

2022 (46 citations)
Castel, G., & David, L. (2022). Induction of human trophoblast stem cells. Nature protocols, 17(12), 2760-2783.
* Y27632, CHIR99021, A83-01, SB431542, PD0325901, GO6983, IWR-endo-1, Foskolin from Axon Medchem

Lesage, R., Ferrao Blanco, M. N., Narcisi, R., Welting, T., van Osch, G. J., & Geris, L. (2022). An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis. Bmc Biology, 20(1), 253.
* Forskolin, PD0325901, PD161570, LDN-193189, and LY294002  from Axon Medchem
 
Martin-Romero, F. J. Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains (2022). link.
Michaut, A., Mongera, A., Gupta, A., Serra, M., Rigoni, P., Lee, J. G., ... & Pourquie, O. (2022). Activity-driven extracellular volume expansion drives vertebrate axis elongation. bioRxiv, 2022-06.
Policarpi, C., Munafò, M., Tsagkris, S., Carlini, V., & Hackett, J. A. (2022). Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications. BioRxiv, 2022-09.
2i: CHIR99021 and PD0325901 from Axon Medchem

Schmidt, C., Deyett, A., Ilmer, T., Haendeler, S., Caballero, A. T., Novatchkova, M., ... & Mendjan, S. (2022). Multi-chamber cardioids unravel human heart development and cardiac defects. Cell.
Rang, F. J., de Luca, K. L., de Vries, S. S., Valdes-Quezada, C., Boele, E., Nguyen, P. D., ... & Kind, J. (2022). Single-cell profiling of transcriptome and histone modifications with EpiDamID. Molecular Cell, 82(10), 1956-1970.
Romayor, I., Herrera, L., Burón, M., Martin-Inaraja, M., Prieto, L., Etxaniz, J., ... & Eguizabal, C. (2022). A Comparative Study of Cell Culture Conditions during Conversion from Primed to Naive Human Pluripotent Stem Cells. Biomedicines, 10(6), 1358.
* CHIR99021, PD0325901, Y27632, Go6983, SP600125 and BIRB796 from Axon Medchem

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Martini, P., & Martello, G. (2022). Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. bioRxiv, 2022-04.
*PD0325901, XAV939, Go6983, Y27632, CHIR99021, A83-01, SB431542 from Axon Medchem

Viukov, S., Shani, T., Bayerl, J., Sheban, D., Stelzer, Y., Novershtern, N., & Hanna, J. H. (2022). Human primed and naïve PSCs are both competent in differentiating into bona fide trophoblast stem cells. BioRxiv, 2022-05.
*PD0325901, XAV939, GO6983, CGP77675, BIRB796, A883-01, CHIR99021, Y27632 etc. from Axon Medchem

Viegas, J. O., Azad, G. K., Lv, Y., Fishman, L., Paltiel, T., Pattabiraman, S., ... & Meshorer, E. (2022). RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2. Developmental Cell, 57(24), 2731-2744.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Stolz, P., Mantero, A. S., Tvardovskiy, A., Ugur, E., Wange, L. E., Mulholland, C. B., ... & Bultmann, S. (2022). TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation. Nucleic Acids Research, 50(15), 8491-8511.
*2i; PD0325901 and CHIR99021 from Axon Medchem

Tarazi, S., Aguilera-Castrejon, A., Joubran, C., Ghanem, N., Ashouokhi, S., Roncato, F., ... & Hanna, J. H. (2022). Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell, 185(18), 3290-3306.
* CHIR99021, PD0325901, Y27632 from Axon Medchem

Girard, O., Lavigne, R., Chevolleau, S., Onfray, C., Com, E., Schmit, P. O., ... & Pineau, C. (2022). Naive Pluripotent and Trophoblastic Stem Cell Lines as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project. Journal of Proteome Research, 22(4), 1148-1158.
* PD0325901, XAV939, GO6983, Y27632 and CHIR99021 from Axon Medchem

Alonso-Alonso, S., Santaló, J., & Ibáñez, E. (2022). Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. Reproduction, Fertility and Development, 34(7), 576-587.
* 2i : PD0325901 and CHIR99021 from Axon Medchem

Luquette, L. J., Miller, M. B., Zhou, Z., Bohrson, C. L., Zhao, Y., Jin, H., ... & Park, P. J. (2022). Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements. Nature Genetics, 54(10), 1564-1571.
*2i; PD0325901 and CHIR99021 from Axon Medchem

Pham, T. X. A., Panda, A., Kagawa, H., Ertekin, C., Georgolopoulos, G., van Knippenberg, S. S., ... & Pasque, V. (2022). Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells. Cell Stem Cell, 29(9), 1346-1365.
* PD0325901, SB431542, CHIR99021, from Axon Medchem

Coppiello, G., Barlabe, P., Moya-Jodar, M., Abizanda, G., Barreda, C., Iglesias, E., ... & Aranguren, X. L. (2022). In vivo generation of heart and vascular system by blastocyst complementation. bioRxiv, 2022-10.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Hauth, A., Galupa, R., Servant, N., Villacorta, L., Hauschulz, K., van Bemmel, J. G., ... & Heard, E. (2022). Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C. JoVE (Journal of Visualized Experiments), (188), e64166.
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Dekel, C., Morey, R., Hanna, J., Laurent, L. C., Ben-Yosef, D., & Amir, H. (2022). Stabilization of hESCs in two distinct substates along the continuum of pluripotency. Iscience, 25(12), 105469.
* CHIR99021, PD0325901, BIRB796, CGP77675  and Y27632 from Axon Medchem

Zijlmans, D. W., Talon, I., Verhelst, S., Bendall, A., Van Nerum, K., Javali, A., ... & Pasque, V. (2022). Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nature Cell Biology, 24(6), 858-871.
* PD0325901, CHIR99021 and SB431542 from Axon Medchem

Skvortsova, E. V., Nazarov, I. B., Tomilin, A. N., & Sinenko, S. A. (2022). Dual Mode of Mitochondrial ROS Action during Reprogramming to Pluripotency. International Journal of Molecular Sciences, 23(18), 10924.
* 2i; PD0325901 and CHIR99021 from Axon Medchem

Viukov, S., Shani, T., Bayerl, J., Aguilera-Castrejon, A., Oldak, B., Sheban, D., ... & Novershtern, N. (2022). Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells. Stem cell reports, 17(11), 2484-2500.
* PD0325901, XAV939, Go6983,Y27632, CGP77675, PD173074 and CHIR99021 from Axon Medchem

Ugur, E., de la Porte, A., Bultmann, S., Drukker, M., Mann, M., Wierer, M., & Leonhardt, H. (2022). Comprehensive chromatin proteomics resolves functional phases of pluripotency. bioRxiv, 2022-08.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Ferdaos, N., Lowell, S., & Mason, J. O. (2022). Pax6 mutant cerebral organoids partially recapitulate phenotypes of Pax6 mutant mouse strains. Plos one, 17(11), e0278147.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Fischer, V., Hisler, V., Scheer, E., Lata, E., Morlet, B., Plassard, D., ... & Vincent, S. D. (2022). SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells. Nucleic Acids Research, 50(14), 7972-7990.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Correia, B., Sousa, M. I., Branco, A. F., Rodrigues, A. S., & Ramalho-Santos, J. (2022). Leucine and Arginine Availability Modulate Mouse Embryonic Stem Cell Proliferation and Metabolism. International Journal of Molecular Sciences, 23(22), 14286.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Wehmeyer, A. E., Schüle, K. M., Conrad, A., Schröder, C. M., Probst, S., & Arnold, S. J. (2022). Chimeric 3D gastruloids–a versatile tool for studies of mammalian peri-gastrulation development. Development, 149(22), dev200812.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Mamberti, S., Pabba, M. K., Rapp, A., Cardoso, M. C., & Scholz, M. (2022). The Chromatin Architectural Protein CTCF Is Critical for Cell Survival upon Irradiation-Induced DNA Damage. International Journal of Molecular Sciences, 23(7), 3896.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Di Minin, G., Holzner, M., Grison, A., Dumeau, C. E., Chan, W., Monfort, A., ... & Wutz, A. (2022). TMED2 binding restricts SMO to the ER and Golgi compartments. PLoS Biology, 20(3), e3001596.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Mukamel, Z., Lifshitz, A., Mittnenzweig, M., Chomsky, E., Schwartzman, O., Ben-Kiki, O., ... & Tanay, A. (2022). DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation. Nature structural & molecular biology, 1-14.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Arroyo, M., Hastert, F. D., Zhadan, A., Schelter, F., Zimbelmann, S., Rausch, C., ... & Cardoso, M. C. (2022). Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation. Nature Communications, 13(1), 5173.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Mach, P., Kos, P. I., Zhan, Y., Cramard, J., Gaudin, S., Tünnermann, J., ... & Giorgetti, L. (2022). Cohesin and CTCF control the dynamics of chromosome folding. Nature Genetics, 1-12.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Mach, P., Kos, P. I., Zhan, Y., Cramard, J., Gaudin, S., Tünnermann, J., ... & Giorgetti, L. (2022). Live-cell imaging and physical modeling reveal control of chromosome folding dynamics by cohesin and CTCF. BioRxiv, 2022-03.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Alonso-Alonso, S., Santaló, J., & Ibáñez, E. (2022). Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. Reproduction, Fertility and Development, 34(7), 576-587.
2i: CHIR99021 and PD0325901 from Axon Medchem

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Martini, P., & Martello, G. (2022). Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. bioRxiv.
* PD0325901, Go6983, Y27632, CHIR99021, A83-01, XAV939, SB431542, PD173074 etc from Axon Medchem

Hiltunen, A. E., Vuolteenaho, R., Ronkainen, V. P., Miinalainen, I., Uusimaa, J., Lehtonen, S., & Hinttala, R. (2022). Nhlrc2 is crucial during mouse gastrulation. genesis, 60(3), e23470.
2i: CHIR99021 and PD0325901 from Axon Medchem
 
Gjaltema, R. A., Schwämmle, T., Kautz, P., Robson, M., Schöpflin, R., Lustig, L. R., ... & Schulz, E. G. (2022). Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus. Molecular Cell, 82(1), 190-208.
2i: CHIR99021 and PD0325901 from Axon Medchem
 
Moya-Jódar, M., Ullate-Agote, A., Barlabé, P., Rodríguez-Madoz, J. R., Abizanda, G., Barreda, C., ... & Aranguren, X. L. (2022). Revealing cell populations catching the early stages of the human embryo development in naïve pluripotent stem cells. bioRxiv.
* Y27632 and PD0325901 from Axon Medchem
 
Rang, F. J., de Luca, K. L., de Vries, S. S., Valdes-Quezada, C., Boele, E., Nguyen, P. D., ... & Kind, J. (2022). Single-cell profiling of transcriptome and histone modifications with EpiDamID. Molecular Cell.
 
Vardapour, R. (2022). Mutations in the DROSHA/DGCR8 microprocessor complex in high-risk blastemal Wilms tumor(Doctoral dissertation, Universität Würzburg).

Di Minin, G., Holzner, M., Grison, A., Dumeau, C. E., Chan, W., Monfort, A., ... & Wutz, A. (2022). TMED2 binding restricts SMO to the ER and Golgi compartments. PLoS Biology, 20(3), e3001596.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Ribeiro, J., & Crossan, G. P. (2022). GCNA is a histone binding protein required for spermatogonial stem cell maintenance. bioRxiv.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Sheban, D., Shani, T., Maor, R., Aguilera-Castrejon, A., Mor, N., Oldak, B., ... & Merbl, Y. (2022). SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. Molecular cell, 82(1), 106-122.
*3i: CHIR 99021, PD 0325901 and Y 27632 from Axon Medchem
 
Kaemena, D. F., Yoshihara, M., Ashmore, J., Beniazza, M., Zhao, S., Bertenstam, M., ... & Kaji, K. (2022). B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening by pioneering factors. bioRxiv.
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem

Sáez, M., Blassberg, R., Camacho-Aguilar, E., Siggia, E. D., Rand, D. A., & Briscoe, J. (2022). Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions. Cell Systems, 13(1), 12-28.
https://www.sciencedirect.com/science/article/pii/S2405471221003367
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem

2021 (37 citations)
Fischer, V., Plassard, D., Ye, T., Reina-San-Martin, B., Stierle, M., Tora, L., & Devys, D. (2021). The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. Cell reports, 36(8), 109598.
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Bernad, R., Lynch, C. J., Urdinguio, R. G., Stephan-Otto Attolini, C., Fraga, M. F., & Serrano, M. (2021). Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19. Cells, 10(4), 876.
2i: CHIR99021 and PD0325901 from Axon Medchem

Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., ... & Hanna, J. H. (2021). Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell stem cell, 28(9), 1549-1565.
* PD0325901, CHIR99021, IWR1, BIR0796, Go6983, Y27632, CGP77675, RIN1, LDN193189, A83-01, SB590885, BIX02189, RU_SKI43, BIX02194 and many other inhibitors from Axon Medcehm

Wang, F., El-Saafin, F., Ye, T., Stierle, M., Negroni, L., Durik, M., ... & Tora, L. (2021). Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription. Cell Death & Differentiation, 28(8), 2385-2403.
2i: CHIR99021 and PD0325901 from Axon Medchem

Tong, Z., Kwak, E., Aguiar, A., Peng, B., Pouton, C. W., Voelcker, N. H., & Haynes, J. M. (2021). Compartmentalized microfluidic chambers enable long-term maintenance and communication between human pluripotent stem cell-derived forebrain and midbrain neurons. Lab on a Chip, 21(20), 4016-4030.

Lesage, R., Blanco, M. N. F., Narcisi, R., Welting, T., van Osch, G. J., & Geris, L. (2021). An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis. bioRxiv.
* PD0325901, Forskolin, PD161570, LDN-193189, LY294002 from Axon Medchem

Wilhelm, T., Toledo, M. A., Simons, I., Stuth, C., Mohta, V., Mülfarth, R., ... & Huber, M. (2021). Capitalizing on paradoxical activation of the MAPK pathway for treatment of Imatinib-resistant mast cell leukemia and chronic myelogenous leukemia. bioRxiv, 2020-08.

Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Betto, R. M., Facchinello, N., ... & Argenton, F. (2021). Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation. Development, 148(17), dev199477.

Gjaltema, R. A., Schwämmle, T., Kautz, P., Robson, M., Schöpflin, R., Lustig, L. R., ... & Schulz, E. G. (2021). Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus. Molecular Cell.
* 2i; CHIR99021 and PD0325901 from Axon Medchem

Festuccia, N., Owens, N., Chervova, A., Dubois, A., & Navarro, P. (2021). The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency. Development, 148(17), dev199604.

Di Stefano, B., & Hochedlinger, K. Reduced MEK inhibition preserves genomic stability in naïve human ES cells. Protocol Exchange, doi, 10. posted 2018, online 2021
https://assets.researchsquare.com/files/nprot-6829/v1/eb3f5184-8291-4206-8e0d-6ed902bce15f.pdf
* CHIR 99021, PD 0325901, IM-12, Y 27632, Go 6983, SB 590885, WH-4-023 from Axon Medchem
 
Fischer, V., Scheer, E., Lata, E., Morlet, B., Plassard, D., Vincent, S. D., ... & Tora, L. (2021). SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells. bioRxiv.
* 2i: CHIR 99021, PD 0325901 from Axon Medchem

Qin, W., Ugur, E., Mulholland, C. B., Bultmann, S., Solovei, I., Modic, M., ... & Leonhardt, H. (2021). Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency. Nucleic acids research, 49(13), 7406-7423.
* 2i: CHIR 99021, PD 0325901 from Axon Medchem

Rausch, C., Zhang, P., Casas-Delucchi, C. S., Daiß, J. L., Engel, C., Coster, G., ... & Cardoso, M. C. (2021). Cytosine base modifications regulate DNA duplex stability and metabolism. Nucleic acids research, 49(22), 12870-12894.
* 2i: CHIR 99021, PD 0325901 from Axon Medchem

Devika, A. S., Montebaur, A., Saravanan, S., Bhushan, R., Koch, F., & Sudheer, S. (2021). Human ES Cell Culture Conditions Fail to Preserve the Mouse Epiblast State. Stem cells international, 2021.
* 2i: CHIR 99021, PD 0325901 from Axon Medchem

Stathakos, P., Jiménez-Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., ... & Lane, J. D. (2021). A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy, 17(4), 855-871.
* 2i: CHIR 99021, PD 0325901 from Axon Medchem

Yoshida, J., Watanabe, H., Yamauchi, K., Nishikubo, T., Isotani, A., Ohtsuka, S., ... & Horie, K. (2021). Inhibition of N-myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem Cells. bioRxiv.
* 2i: CHIR 99021, PD 0325901 from Axon Medchem

Fabyanic, E. B., Hu, P., Qiu, Q., Wang, T., Berríos, K. N., Flournoy, J., ... & Wu, H. (2021). Quantitative single cell 5hmC sequencing reveals non-canonical gene regulation by non-CG hydroxymethylation. bioRxiv.
* 2i: CHIR 99021, PD 0325901 from Axon Medchem

Fischer, V., Plassard, D., Ye, T., Reina-San-Martin, B., Stierle, M., Tora, L., & Devys, D. (2021). The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. Cell reports, 36(8), 109598.
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem

Scheer, E., Luo, J., Bernardini, A., Ruffenach, F., Garnier, J. M., Kolb-Cheynel, I., ... & Tora, L. (2021). TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival. Journal of Biological Chemistry, 297(5).
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem

Desai, V. P., Chouaref, J., Wu, H., Pastor, W. A., Kan, R. L., Oey, H. M., ... & Daxinger, L. (2021). The role of MORC3 in silencing transposable elements in mouse embryonic stem cells. Epigenetics & chromatin, 14(1), 1-14.
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem

Genolet Alberdi, O. (2021). Identification of X-chromosomal genes that drive global X-dosage effects in mammals (Doctoral dissertation).
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem
 
Kobayashi, T., Goto, T., Oikawa, M., Sanbo, M., Yoshida, F., Terada, R., ... & Hirabayashi, M. (2021). Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats. Nature communications, 12(1), 1-10.
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem

Schütz, A., Richter, C., Weissgerber, P., Tsvilovskyy, V., Hesse, M., Ottenheijm, R., ... & Freichel, M. (2021). Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos. Cell Reports, 37(3), 109851.
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem

Bruzelius, A., Kidnapillai, S., Drouin-Ouellet, J., Stoker, T., Barker, R. A., & Rylander Ottosson, D. (2021). Reprogramming human adult fibroblasts into GABAergic interneurons. Cells, 10(12), 3450.
* CHIR 99021, PD 0325901 and LDN 193189 from Axon Medchem

Zuin, J., Roth, G., Zhan, Y., Cramard, J., Redolfi, J., Piskadlo, E., ... & Giorgetti, L. (2021). Nonlinear control of transcription through enhancer-promoter interactions. bioRxiv.
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem
 
Yin, H., Wei, C., & Lee, J. T. (2021). Revisiting the consequences of deleting the X inactivation center. Proceedings of the National Academy of Sciences, 118(25).
* 2i: CHIR 99021 and PD 0325901 from Axon Medchem

Pantier, R., Chhatbar, K., Quante, T., Skourti-Stathaki, K., Cholewa-Waclaw, J., Alston, G., ... & Bird, A. (2021). SALL4 controls cell fate in response to DNA base composition. Molecular cell, 81(4), 845-858.
SALL4 controls cell fate in response to DNA base composition
2i: CHIR99021 and PD0325901 from Axon Medchem

Bernad, R., Lynch, C. J., Urdinguio, R. G., Stephan-Otto Attolini, C., Fraga, M. F., & Serrano, M. (2021). Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19. Cells, 10(4), 876.
https://www.mdpi.com/2073-4409/10/4/876/htm
2i : CHIR99021 and PD0325901 from Axon Medchem

Martinez-Val, A., Lynch, C. J., Calvo, I., Ximénez-Embún, P., Garcia, F., Zarzuela, E., ... & Munoz, J. (2021). Dissection of two routes to naïve pluripotency using different kinase inhibitors. Nature Communications, 12(1), 1-16.
https://www.nature.com/articles/s41467-021-22181-5
2i: CHIR99021 and PD0325901 from Axon Medchem

Genolet, O., Monaco, A. A., Dunkel, I., Boettcher, M., & Schulz, E. G. (2021). Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach. Genome Biology, 22(1), 1-41.
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-021-02321-2
2i: CHIR99021 and PD0325901 from Axon Medchem

Modic, M., de Los Mozos, I. R., Steinhauser, S., van Genderen, E., Schirge, S., Bergant, V., ... & Ule, J. (2021). Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation. bioRxiv.
https://www.biorxiv.org/content/10.1101/2021.03.15.433780v1.full

Bartoschek, M. D., Ugur, E., Nguyen, T. A., Rodschinka, G., Wierer, M., Lang, K., & Bultmann, S. (2021). Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells. Nucleic Acids Research.
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab132/6158120?login=true
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Qin, W., Stengl, A., Ugur, E., Leidescher, S., Ryan, J., Cardoso, M. C., & Leonhardt, H. (2021). HP1β carries an acidic linker domain and requires H3K9me3 for phase separation. Nucleus, 12(1), 44-57.
https://www.tandfonline.com/doi/full/10.1080/19491034.2021.1889858
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Chang, W. F., Peng, M., Hsu, J., Xu, J., Cho, H. C., Hsieh-Li, H. M., ... & Sung, L. Y. (2021). Effects of Survival Motor Neuron Protein on Germ Cell Development in Mouse and Human. International Journal of Molecular Sciences, 22(2), 661.
https://www.mdpi.com/1422-0067/22/2/661
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Wang, F., El-Saafin, F., Ye, T., Stierle, M., Negroni, L., Durik, M., ... & Tora, L. (2021). Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription. bioRxiv.
https://www.biorxiv.org/content/10.1101/2021.02.23.432458v1.abstract
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Mitsunaga, S., Shioda, K., Hanna, J. H., Isselbacher, K. J., & Shioda, T. (2021). Production and Analysis of Human Primordial Germ Cell–Like Cells. In Testicular Germ Cell Tumors (pp. 125-145). Humana, New York, NY.
Production and Analysis of Human Primordial Germ Cell–Like Cells
* 2i: CHIR99021 and PD0325901 from Axon Medchem

2020 (44 citations)
Han, B. Y., Seah, M. K., Brooks, I. R., Quek, D. H., Huxley, D. R., Foo, C. S., ... & Guccione, E. (2020). Global translation during early development depends on the essential transcription factor PRDM10. Nature communications, 11(1), 1-14.
Global translation during early development depends on the essential transcription factor PRDM10
2i: CHIR99021 and PD0325901 from Axon Medchem
 
Lynch, C. J., Bernad, R., Martínez-Val, A., Shahbazi, M. N., Nóbrega-Pereira, S., Calvo, I., ... & Serrano, M. (2020). Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nature Cell Biology, 22(10), 1223-1238.
https://www.nature.com/articles/s41556-020-0573-1. 
* CHIR99021, PD0325901 and BIRB796 from Axon Medchem

Ma, B., Trieu, T. J., Habib, S. J., & Chen, X. (2020). Protocol for Establishing Mouse Embryonic Stem Cells to Study Histone Inheritance Pattern at Single-Cell Resolution. STAR protocols, 1(3), 100178.
https://www.sciencedirect.com/science/article/pii/S2666166720301659
2i: CHIR99021 and PD0325901 from Axon Medchem

Castel, G., Meistermann, D., Bretin, B., Firmin, J., Blin, J., Loubersac, S., ... & David, L. (2020). Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells. Cell Reports, 33(8), 108419.
https://www.sciencedirect.com/science/article/pii/S221112472031408X
* 8 inhibitors are from Axon Medchem, including CHIR99021, PD0325901, Y27632, IWR-1, A83-01, SB431542, Go6983, Forskolin.

Dries, R., Stryjewska, A., Coddens, K., Okawa, S., Notelaers, T., Birkhoff, J., ... & Huylebroeck, D. (2020). Integrative and perturbation‐based analysis of the transcriptional dynamics of TGFβ/BMP system components in transition from embryonic stem cells to neural progenitors. Stem Cells, 38(2), 202-217.
https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3111
2i: CHIR99021 and PD0325901 from Axon Medchem

Sangokoya, C., & Blelloch, R. (2020). MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis. Proceedings of the National Academy of Sciences, 117(34), 20625-20635.
https://www.pnas.org/content/117/34/20625.full
2i: CHIR99021 and PD0325901 from Axon Medchem

Stathakos, P., Jiménez-Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., ... & Lane, J. D. (2020). A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy, 1-17.
https://www.tandfonline.com/doi/full/10.1080/15548627.2020.1739441
2i: CHIR99021 and PD0325901 from Axon Medchem

Postlmayr, A., Dumeau, C. E., & Wutz, A. (2020). Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. Development, 147(11).
https://dev.biologists.org/content/147/11/dev175141.full
2i: CHIR99021 and PD0325901 from Axon Medchem

Qiu, Q., Hu, P., Qiu, X., Govek, K. W., Cámara, P. G., & Wu, H. (2020). Massively parallel and time-resolved RNA sequencing in single cells with scNT-seq. Nature methods, 17(10), 991-1001.
https://www.nature.com/articles/s41592-020-0935-4
2i: CHIR99021 and PD0325901 from Axon Medchem

Castel, G., Meistermann, D., Bretin, B., Firmin, J., Justine, B. L. I. N., Loubersac, S., ... & David, L. (2020). Generation of human induced trophoblast stem cells. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.09.15.298257v1.full
5i: CHIR99021, PD0325901, Y27632, PD173074 from Axon Medchem

Luo, X., van der Veer, B. K., Sun, L., Bartoccetti, M., Boretto, M., Vankelecom, H., ... & Koh, K. P. (2020). Coordination of germ layer lineage choice by TET1 during primed pluripotency. Genes & development, 34(7-8), 598-618.
http://genesdev.cshlp.org/content/34/7-8/598.full
2i: CHIR99021 and PD0325901 from Axon Medchem

Bayerl, J., Ayyash, M., Shani, T., Manor, Y., Gafni, O., Kalma, Y., ... & Hanna, J. H. (2020). Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.05.23.112433v1.full
(* CHIR99021, PD0325901, IWR-1, XAV939, BIRB0796, Go6983, Y27632, CGP77675, LDN193189, A83-01, DBZ, SB590885, BIX02189, RU-SKI43, BIX-02194 etc.)

Bustos, F., Segarra-Fas, A., Nardocci, G., Cassidy, A., Antico, O., Davidson, L., ... & Findlay, G. M. (2020). Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling. Developmental cell, 55(5), 629-647.
https://www.sciencedirect.com/science/article/pii/S1534580720307577
* CHIR99021, PD0325901 and SPHINX31 from Axon Medchem

Vila-Cejudo, M., Alonso-Alonso, S., Pujol, A., Santaló, J., & Ibáñez, E. (2020). Wnt pathway modulation generates blastomere-derived mouse embryonic stem cells with different pluripotency features. Journal of Assisted Reproduction and Genetics, 37(12), 2967-2979.
https://link.springer.com/article/10.1007/s10815-020-01964-7
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Alendar, A., Lambooij, J. P., Bhaskaran, R., Lancini, C., Song, J. Y., van Vugt, H., ... & Berns, A. (2020). Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development. PloS one, 15(5), e0233394.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233394
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Weinberger, L. (2020). Characterization of human naive pluripotent stem cells and their differentiation to Primordial Germ Cells (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1274955990003596/1374919490003596
* CHIR99021, PD0325901, SB202190, BIRB796, Y27632, CGP77675 from Axon Medchem

Ma, B., Trieu, T. J., Cheng, J., Zhou, S., Tang, Q., Xie, J., ... & Chen, X. (2020). Differential histone distribution patterns in induced asymmetrically dividing mouse embryonic stem cells. Cell Reports, 32(6), 108003.
https://www.sciencedirect.com/science/article/pii/S2211124720309888
*2i: CHIR99021 and PD0325901 from Axon Medchem

Lasman, L., Krupalnik, V., Viukov, S., Mor, N., Aguilera-Castrejon, A., Schneir, D., ... & Hanna, J. H. (2020). Context-dependent functional compensation between Ythdf m6A reader proteins. Genes & development, 34(19-20), 1373-1391.
https://www.biorxiv.org/content/biorxiv/early/2020/06/03/2020.06.03.131441.full.pdf
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Gafni, O. (2020). Delineating routes and applications of naive pluripotency (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275016610003596/1375015210003596
* CHIR99021, PD0325901, SB201920, Y27632, BIRB796 from Axon Medchem

Mulholland, C. B., Traube, F. R., Ugur, E., Parsa, E., Eckl, E. M., Schönung, M., ... & Bultmann, S. (2020). Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency. Scientific reports, 10(1), 1-12.
https://www.nature.com/articles/s41598-020-68600-3?elqTrackId=f22b504ca3bf400ca13ed38bda449fd7
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Fischer, V., Plassard, D., Ye, T., San Martin, B. R., Stierle, M., Tora, L., & Devys, D. Two Related Coactivator Complexes SAGA and ATAC Control Embryonic Stem Cell Self-Renewal Through Two Different Acetyltransferase-Independent Mechanisms. Available at SSRN 3782006.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3782006
* 2i : CHIR99021 and PD0325901 from Axon Medchem

Ignatova, V. V., Stolz, P., Kaiser, S., Gustafsson, T. H., Lastres, P. R., Sanz-Moreno, A., ... & Schneider, R. (2020). The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes & development, 34(9-10), 715-729.
http://genesdev.cshlp.org/content/34/9-10/715.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Spada, F., Schiffers, S., Kirchner, A., Zhang, Y., Arista, G., Kosmatchev, O., ... & Carell, T. (2020). Active turnover of genomic methylcytosine in pluripotent cells. Nature Chemical Biology, 16(12), 1411-1419.
https://www.nature.com/articles/s41589-020-0621-y
* from Axon Medchem (CHIR, CGP, PD, IWR1)

Krupalnik, V. (2020). Aire as a novel factor promoting induction of pluripotency (Doctoral dissertation, The Weizmann Institute of Science).
https://weizmann.esploro.exlibrisgroup.com/view/delivery/972WIS_INST/1275016260003596/1375015250003596
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Rausch, C., Weber, P., Prorok, P., Hörl, D., Maiser, A., Lehmkuhl, A., ... & Cardoso, M. C. (2020). Developmental differences in genome replication program and origin activation. Nucleic acids research, 48(22), 12751-12777.
https://academic.oup.com/nar/article/48/22/12751/6017362?login=true
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Di Minin, G., Dumeau, C. E., Grison, A., Chan, W., Monfort, A., Jerome-Majewska, L. A., & Wutz, A. (2020). Tmed2 regulates Smoothened trafficking and Hedgehog signalling. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.04.20.049957v1.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Mulholland, C. B., Nishiyama, A., Ryan, J., Nakamura, R., Yiğit, M., Glück, I. M., ... & Leonhardt, H. (2020). Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nature communications, 11(1), 1-24.
https://www.nature.com/articles/s41467-020-19603-1
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Pieters, T., Sanders, E., Tian, H., van Hengel, J., & Van Roy, F. (2020). Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice. BMC developmental biology, 20(1), 1-18.
https://link.springer.com/article/10.1186/s12861-020-00222-4
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Warzych, E., Pawlak, P., Lechniak, D., & Madeja, Z. E. (2020). WNT signalling supported by MEK/ERK inhibition is essential to maintain pluripotency in bovine preimplantation embryo. Developmental biology, 463(1), 63-76.
https://www.sciencedirect.com/science/article/pii/S001216062030124X
* many inhibitors used were from Axon Medchem

Ito, H., Watari, K., Shibata, T., Miyamoto, T., Murakami, Y., Nakahara, Y., ... & Ono, M. (2020). Bidirectional regulation between NDRG1 and GSK3β controls tumor growth and is targeted by differentiation inducing factor-1 in glioblastoma. Cancer research, 80(2), 234-248.
https://cancerres.aacrjournals.org/content/80/2/234.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Genolet, O., Monaco, A. A., Dunkel, I., Boettcher, M., & Schulz, E. G. (2020). Identification of X-chromosomal genes that drive global X-dosage effects in mammals. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.03.09.983544v1.full
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Nishiyama, A., Mulholland, C. B., Bultmann, S., Kori, S., Endo, A., Saeki, Y., ... & Kumamoto, S. (2020). Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nature Communications, 11(1), 1-17.
https://www.nature.com/articles/s41467-020-15006-4
2i: PD0325901 and CHIR99021 from Axon Medchem

Katsuda, T., Kawamata, M., Inoue, A., Yamaguchi, T., Abe, M., & Ochiya, T. (2020). Long‐term maintenance of functional primary human hepatocytes using small molecules. FEBS letters, 594(1), 114-125.
https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13582
2i: CHIR99021 and PD0325901 from Axon Medchem

Rahimoff, R., & KSR, K. S. R. (2020). 4 Material und Methoden der unveröffentlichten Arbeiten. Untersuchung des Metabolismus nicht-kanonischer DNA-Basen in embryonalen Stammzellen, 121.
https://edoc.ub.uni-muenchen.de/25568/1/Kirchner_Angie_G.pdf#page=137
*3i: PD0325901, CHIR99021, and CGP77675 from Axon Medchem

Bartoccetti, M., van der Veer, B. K., Luo, X., Khoueiry, R., She, P., Bajaj, M., ... & Koh, K. P. (2020). Regulatory dynamics of Tet1 and Oct4 resolve stages of global DNA demethylation and transcriptomic changes in reprogramming. Cell reports, 30(7), 2150-2169.
https://www.sciencedirect.com/science/article/pii/S2211124720300905
*2i: CHIR99021 and PD0325901 from Axon Medchem

Xiang, Y., Cakir, B., & Park, I. H. (2020). Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development. STAR protocols, 1(1), 100001.
https://www.sciencedirect.com/science/article/pii/S2666166719300012

Vered, I. (2020). Analysis of translesion DNA synthesis in embryonic stem cells (Doctoral dissertation, The Weizmann Institute of Science).
Analysis of translesion DNA synthesis in embryonic stem cells
2i: CHIR99021 and PD0325901 from Axon Medchem 

Cao, B., Wang, G., Li, J., & Pertsinidis, A. (2020). 3D Interferometric Lattice Light-Sheet Imaging. bioRxiv.
3D Interferometric Lattice Light-Sheet Imaging

Wilhelm, T., Simons, I., Stuth, C., Mohta, V., Mülfarth, R., Nitsche, M., ... & Huber, M. (2020). Capitalizing on paradoxical activation of the MAPK pathway for treatment of Imatinib-resistant mast cell leukemia and chronic myelogenous leukemia. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.08.31.266734v1.full

Meek, S., Wei, J., Oh, T., Watson, T., Olavarrieta, J., Sutherland, L., ... & Burdon, T. (2020). A Stem Cell Reporter for Investigating Pluripotency and Self-Renewal in the Rat. Stem Cell Reports. 14 (1), 154-166.
https://www.sciencedirect.com/science/article/pii/S2213671119304151

Precious, S. V., Smith, G. A., Heuer, A., Jaeger, I., Lane, E. L., Dunnett, S. B., ... & Rosser, A. E. (2020). Dopaminergic Progenitors Derived From Epiblast Stem Cells Function Similarly to Primary VM-Derived Progenitors When Transplanted Into a Parkinson’s Disease Model. Frontiers in neuroscience, 14.
Dopaminergic Progenitors Derived From Epiblast Stem Cells Function Similarly to Primary VM-Derived Progenitors When Transplanted Into a Parkinson's …

Ma, H., Hayama, T., Van Dyken, C., Darby, H., Koski, A., Lee, Y., ... & Mitalipov, S. (2020). Deleterious mtDNA mutations are common in mature oocytes. Biology of reproduction, 102(3), 607-619.
https://academic.oup.com/biolreprod/article/102/3/607/5588758?login=true
2i: CHIR99021 and PD0325901 from Axon

Posfai, E., Schell, J. P., Janiszewski, A., Rovic, I., Murray, A., Bradshaw, B., ... & Rossant, J. (2020). Defining totipotency using criteria of increasing stringency. BioRxiv.
https://www.biorxiv.org/content/10.1101/2020.03.02.972893v1.full
2i: CHIR99021 and PD0325901 from Axon

Pacini, G., Dunkel, I., Mages, N., Mutzel, V., Timmermann, B., Marsico, A., & Schulz, E. G. (2020). Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolution. bioRxiv.
https://www.biorxiv.org/content/10.1101/2020.07.20.211573v1.full
2i: CHIR99021 and PD0325901 from Axon Medchem

2019 (52 citations)
Karoutas, A., Szymanski, W., Rausch, T., Guhathakurta, S., Rog-Zielinska, E. A., Peyronnet, R., ... & Kimura, H. (2019). The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nature Cell Biology, 21(10), 1248-1260.  
https://www.nature.com/articles/s41556-019-0397-z
*2i: CHIR99021 and PD0325901 from Axon Medchem

Madeja, Z. E., Warzych, E., Pawlak, P., & Lechniak, D. (2019). Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications, 510(3), 403-408.
https://www.sciencedirect.com/science/article/abs/pii/S0006291X19301421
*CHIR99021, PD0325901, PD184352 and SU5402 from Axon Medchem

M A Garcia-Campos, S Edelheit, U Toth, M Safra, R Shachar, S Viukov, R Winkler, R tNir, L Lasman, A Brandis, J H.Hanna, W Rossmanith, S Schwartz. Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling. Cell, 2019, 178 (3), 731-747.
https://www.sciencedirect.com/science/article/pii/S0092867419306762
*2i: CHIR99021 and PD0325901 from Axon medchem.

Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2019). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nat. Cell Biol, 21, 1-19.
https://www.nature.com/articles/s41556-018-0254-5.pdf?origin=ppub
*6i: CHIR99021, PD0325901, GO6983, WH-4-023, SB590885, and Y27632 from Axon Medchem

Heurtier, V., Owens, N., Gonzalez, I., Mueller, F., Proux, C., Mornico, D., ... & Navarro, P. (2019). The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells. Nature communications, 10(1), 1109.
https://www.nature.com/articles/s41467-019-09041-z
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Kamenova, I., Mukherjee, P., Conic, S., Mueller, F., El-Saafin, F., Bardot, P., ... & Vincent, S. D. (2019). Co-translational assembly of mammalian nuclear multisubunit complexes. Nature communications, 10(1), 1-15.
https://www.nature.com/articles/s41467-019-09749-y
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Rooijers, K., Markodimitraki, C. M., Rang, F. J., de Vries, S. S., Chialastri, A., de Luca, K. L., ...  Dey, S. & Kind, J. (2019). Simultaneous quantification of protein–DNA contacts and transcriptomes in single cells. Nature biotechnology, 37(7), 766-772.
https://www.nature.com/articles/s41587-019-0150-y
*2i: CHIR99021 and PD0325901 from Axon Medchem

Rooijers, K., Markodimitraki, C. M., Rang, F. J., de Vries, S. S., Chialastri, A., de Luca, K. L., ... & Kind, J. (2019). scDam&T‐seq combines DNA adenine methyltransferase-based labeling of protein-DNA contact sites with transcriptome sequencing to analyze regulatory programs in single cells. Nature biotechnology, 37(7), 766.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609448/
*2i: CHIR99021 and PD0325901 from Axon Medchem

B. Di Stefano, E.C. Luo, C. Haggerty, ..., A. Meissner, Gene W. Yeo, K. Hochedlinger (2019) The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. Cell Stem Cell, 25, 1-17.
http://yeolab.github.io/papers/2019/Stefano_Enching_cellstemmcell_2019.pdf
* IM-12, SB590885, WH-4-23, PD0325901, CHIR99021, Y-27632 from Axon Medchem

Heap, R. E., Segarra-Fas, A., Blain, A. P., Findlay, G. M., & Trost, M. (2019). Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow. Analyst, 144(21), 6371-6381.
https://pubs.rsc.org/en/content/articlehtml/2019/an/c9an00771g
2i: CHIR99021 and PD0325901 from Axon Medchem

Qiu, Q., Hu, P., Govek, K. W., Camara, P. G., & Wu, H. (2019). Massively parallel, time-resolved single-cell RNA sequencing with scNT-Seq. bioRxiv.
https://www.biorxiv.org/content/10.1101/2019.12.19.882050v1.full
2i: CHIR99021 and PD0325901 from Axon Medchem

Dierickx, P., Emmett, M. J., Jiang, C., Uehara, K., Liu, M., Adlanmerini, M., & Lazar, M. A. (2019). SR9009 has REV-ERB–independent effects on cell proliferation and metabolism. Proceedings of the National Academy of Sciences, 116(25), 12147-12152.
https://www.pnas.org/content/116/25/12147
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Malaguti, M., Migueles, R. P., Blin, G., Lin, C. Y., & Lowell, S. (2019). Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation. Developmental cell. 50(4), 462-477.
https://www.sciencedirect.com/science/article/pii/S1534580719304459
* CHIR99021, LDN193189 and PD0325901 from Axon Medchem

Weber, P., Rausch, C., Scholl, A., & Cardoso, M. C. (2019). Repli-FISH (Fluorescence in Situ Hybridization): Application of 3D-(Immuno)-FISH for the Study of DNA Replication Timing of Genetic Repeat Elements.
http://www.cardoso-lab.org/publications/Weber,%20Rausch%202019.pdf
*2i: CHIR99021 and PD0325901 from Axon Medchem

Wu, H., Vonk, K. K., van der Maarel, S. M., Santen, G. W., & Daxinger, L. (2019). A functional assay to classify ZBTB24 missense variants of unknown significance. Human mutation.
https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.23786
2i: CHIR99021 and PD0325901 from Axon Medchem

Boonen, T. M. P. M. (2019). Development of a myocardial infarction model by the design of a miniaturized 3D culture platform (Master's thesis, University of Twente).
https://essay.utwente.nl/79975/1/Master%20thesis%20T.M.P.M.%20Boonen.pdf

Azacytidines Directly in the Genome. Helvetica Chimica Acta, 102(3), e1800229.
https://onlinelibrary.wiley.com/doi/abs/10.1002/hlca.201800229
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Aizawa, E., 2019. Characterization of in vitro systems to generate oocytes and substitutes of sperm from pluripotent stem cells (Doctoral dissertation, ETH Zurich).
https://www.research-collection.ethz.ch/bitstream/handle/20.500.11850/391005/1/Dissertation_EishiAizawa.pdf
* 2i: CHIR99021 and PD0325901 from Axon Medchem

Spada, F., Schiffers, S., Kirchner, A., Zhang, Y., Kosmatchev, O., Korytiakova, E., ... & Carell, T. (2019). Oxidative and non-oxidative active turnover of genomic methylcytosine in distinct pluripotent states. BioRxiv, 846584.
https://www.biorxiv.org/content/10.1101/846584v1.full
* Axon Medchem (CHIR, CGP, PD, IWR1)

Amit, I., David, L.A. and Meital, G.U.R.Y., Yeda Research and Development Co Ltd, 2019. Methods and kits for analyzing dna binding moieties attached to dna. U.S. Patent Application 16/319,499.
https://patents.google.com/patent/US20190203270A1/en
* 2i: PD0325901 and CHIR99021 from Axon Medchem

Hill, R. J., & Crossan, G. P. (2019). DNA cross-link repair safeguards genomic stability during premeiotic germ cell development. Nature genetics, 51(8), 1283.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675612/
2i: Pd0325901 and CHIR99021 from Axon Medchem

Canizo, J. R., Rivolta, A. E. Y., Echegaray, C. V., Suvá, M., Alberio, V., Aller, J. F., ... & Alberio, R. (2019). A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos. BMC developmental biology, 19(1), 13.
https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-019-0193-9
*PD0325901, GO6983 from Axon Medchem

OCHIYA, T; KATSUDA, T. Method for producing hepatic stem/precursor cells from mature hepatic cells using low-molecular-weight compound. U.S. Patent Application No 16/068,607, 2019.
*CHIR99021, PD0325901 and GSK269962A from Axon Medchem

Vila-Cejudo, M., Massafret, O., Santaló, J., & Ibáñez, E. (2019). Single blastomeres as a source of mouse embryonic stem cells: effect of genetic background, medium supplements, and signaling modulators on derivation efficiency. Journal of assisted reproduction and genetics, 36(1), 99-111.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Zviran, A., Mor, N., Rais, Y., Gingold, H., Peles, S., Chomsky, E., ... & Manor, Y. S. (2019). Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules. Cell stem cell, 24(2), 328-341.
*2i: CHIR99021, PD0325901, and 10058-F4 from Axon Medchem

An, S., Park, U. H., Moon, S., Kang, M., Youn, H., Hwang, J. T., ... & Um, S. J. (2019). Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal. Biochemical and biophysical research communications, 508(3), 907-913.
*3i: SU5402, PD0325901 and CHIR99021 from Axon Medchem

Khateb, M., Azriel, A., & Levi, B. Z. (2019). The Third Intron of IRF8 Is a Cell-Type-Specific Chromatin Priming Element during Mouse Embryonal Stem Cell Differentiation. Journal of molecular biology, 431(2), 210-222.
*2i: PD0325910 and CHIR99021 from Axon Medchem
 
Heap, R. E., Fas, A. S., Findlay, G., & Trost, M. (2019). Profiling embryonic stem cell differentiation by MALDI-MS: development of a reproducible and robust sample preparation workflow. bioRxiv, 536664.
*2i: PD0325901 and CHIR99021 from Axon Medchem
 
Madeja, Z. E., Warzych, E., Pawlak, P., & Lechniak, D. (2019). Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications.
*2i: CHIR99021, PD0325901, PD184352, SU5402 from Axon Medchem
 
Rooijers, K., Markodimitraki, C., Rang, F., de Vries, S., Chialastri, A., de Luca, K., ... & Dey, S. (2019). Simultaneous quantification of protein-DNA contacts and transcriptomes in single cells. bioRxiv, 529388.
*2i: CHIR99021 and PD0325901 from Axon Medchem

Xiang, Y., Tanaka, Y., Cakir, B., Patterson, B., Kim, K. Y., Sun, P., ... & Park, I. H. (2019). hESC-derived thalamic organoids form reciprocal projections when fused with cortical organoids. Cell stem cell, 24(3), 487-497.
https://www.sciencedirect.com/science/article/pii/S1934590918306052

Tanis, S. E., Köksal, E. S., van Buggenum, J. A., & Mulder, K. W. (2019). BLNCR is a long non-coding RNA adjacent to integrin beta-1 that is rapidly lost during epidermal progenitor cell differentiation. Scientific reports, 9(1), 1-10.
https://www.nature.com/articles/s41598-018-37251-w

Modic, M., Grosch, M., Rot, G., Schirge, S., Lepko, T., Yamazaki, T., ... & Drukker, M. (2019). Cross-regulation between TDP-43 and paraspeckles promotes pluripotency-differentiation transition. Molecular cell, 74(5), 951-965.
https://www.sciencedirect.com/science/article/pii/S1097276519302709

Canizo, J. R., Rivolta, A. E. Y., Echegaray, C. V., Suvá, M., Alberio, V., Aller, J. F., ... & Alberio, R. (2019). A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos. BMC developmental biology, 19(1), 1-13.
https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-019-0193-9

Santos‐Ferreira, T., Herbig, M., Otto, O., Carido, M., Karl, M. O., Michalakis, S., ... & Ader, M. (2019). Morpho‐Rheological Fingerprinting of Rod Photoreceptors Using Real‐Time Deformability Cytometry. Cytometry Part A, 95(11), 1145-1157.
https://onlinelibrary.wiley.com/doi/full/10.1002/cyto.a.23798

Madeja, Z. E., Warzych, E., Pawlak, P., & Lechniak, D. (2019). Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications, 510(3), 403-408.
Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts
** 

Hamilton, W. B., Mosesson, Y., Monteiro, R. S., Emdal, K. B., Knudsen, T. E., Francavilla, C., ... & Brickman, J. M. (2019). Dynamic lineage priming is driven via direct enhancer regulation by ERK. Nature, 575(7782), 355-360.
https://www.nature.com/articles/s41586-019-1732-z
**

Hill, R. J., & Crossan, G. P. (2019). DNA cross-link repair safeguards genomic stability during premeiotic germ cell development. Nature genetics, 51(8), 1283-1294.
DNA cross-link repair safeguards genomic stability during premeiotic germ cell development
**

Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., ... & Belmonte, J. C. I. (2019). Generation of blastocyst-like structures from mouse embryonic and adult cell cultures. Cell, 179(3), 687-702.
Generation of blastocyst-like structures from mouse embryonic and adult cell cultures

Li, J., Dong, A., Saydaminova, K., Chang, H., Wang, G., Ochiai, H., ... & Pertsinidis, A. (2019). Single-molecule nanoscopy elucidates RNA polymerase II transcription at single genes in live cells. Cell, 178(2), 491-506.
https://www.sciencedirect.com/science/article/pii/S0092867419305574

Keränen, T. (2019). The MAP Kinase/MAP Kinase Phosphatase-1 Pathway in the Anti-Inflammatory Effects of β2-Agonists and Dexamethasone.
https://trepo.tuni.fi/bitstream/handle/10024/117876/978-952-03-1292-3.pdf?sequence=5&isAllowed=y
*PD, BIRB796 and Rolipram from Axon Medichem

Xiang, Y., Tanaka, Y., Cakir, B., Patterson, B., Kim, K. Y., Sun, P., ... & Park, I. H. (2019). hESC-derived thalamic organoids form reciprocal projections when fused with cortical organoids. Cell stem cell, 24(3), 487-497.
https://www.sciencedirect.com/science/article/pii/S1934590918306052

van Mierlo, G., Dirks, R. A., De Clerck, L., Brinkman, A. B., Huth, M., Kloet, S. L., ... & Bock, C. (2019). Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency. Cell Stem Cell, 24(1), 123-137.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
OCHIYA, T; KATSUDA, T. Method for producing hepatic stem/precursor cells from mature hepatic cells using low-molecular-weight compound. U.S. Patent Application No 16/068,607, 2019.
*CHIR99021, PD0325901 and GSK269962A from Axon Medchem
 
Vila-Cejudo, M., Massafret, O., Santaló, J., & Ibáñez, E. (2019). Single blastomeres as a source of mouse embryonic stem cells: effect of genetic background, medium supplements, and signaling modulators on derivation efficiency. Journal of assisted reproduction and genetics, 36(1), 99-111.
* 2i: CHIR99021 and PD0325901 from Axon Medchem
 
Zviran, A., Mor, N., Rais, Y., Gingold, H., Peles, S., Chomsky, E., ... & Manor, Y. S. (2019). Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules. Cell stem cell, 24(2), 328-341.
*2i: CHIR99021 and PD0325901, and 10058-F4 from Axon Medchem
 
Tanis, S. E., Köksal, E. S., van Buggenum, J. A., & Mulder, K. W. (2019). BLNCR is a long non-coding RNA adjacent to integrin beta-1 that is rapidly lost during epidermal progenitor cell differentiation. Scientific reports, 9(1), 31.
 
An, S., Park, U. H., Moon, S., Kang, M., Youn, H., Hwang, J. T., ... & Um, S. J. (2019). Asxl1 ablation in mouse embryonic stem cells impairs neural differentiation without affecting self-renewal. Biochemical and biophysical research communications, 508(3), 907-913.
*3i: SU5402, PD0325901 and CHIR99021 from Axon Medchem
 
Khateb, M., Azriel, A., & Levi, B. Z. (2019). The Third Intron of IRF8 Is a Cell-Type-Specific Chromatin Priming Element during Mouse Embryonal Stem Cell Differentiation. Journal of molecular biology, 431(2), 210-222.
*2i: PD0325910 and CHIR99021 from Axon Medchem
 
Heap, R. E., Fas, A. S., Findlay, G., & Trost, M. (2019). Profiling embryonic stem cell differentiation by MALDI-MS: development of a reproducible and robust sample preparation workflow. bioRxiv, 536664.
*2i: PD0325901 and CHIR99021 from Axon Medchem
 
Madeja, Z. E., Warzych, E., Pawlak, P., & Lechniak, D. (2019). Inhibitor mediated WNT and MEK/ERK signalling affects apoptosis and the expression of quality related genes in bovine in vitro obtained blastocysts. Biochemical and biophysical research communications.
2i: CHIR99021, PD0325901, PD184352, SU5402 from Axon Medchem
 
Rooijers, K., Markodimitraki, C., Rang, F., de Vries, S., Chialastri, A., de Luca, K., ... & Dey, S. (2019). Simultaneous quantification of protein-DNA contacts and transcriptomes in single cells. bioRxiv, 529388.
* 2i: CHIR99021 and PD0325901 from Axon Medchem
 
Schiffers, S., Wildenhof, T. M., Iwan, K., Stadlmeier, M., Müller, M., & Carell, T. (2019). Label‐Free Quantification of 5‐Azacytidines Directly in the Genome. Helvetica Chimica Acta.
* 2i: CHIR99021 and PD0325901 from Axon Medchem
 
2018 (32 citations)
Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2018). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nature cell biology.
*6i: CHIR99021, PD0325901, GO6983, WH-4-023, SB590885, and Y27632 from Axon Medchem
 
Mor, N., Rais, Y., Sheban, D., Peles, S., Aguilera-Castrejon, A., Zviran, A., ... & Hanna J.H. (2018). Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. Cell stem cell. 23 (3), 412-425.e10
*CHIR99021, PD0325901, GO6983, CPG77675, Y27632, DBZ from Axon Medchem
 
Barakat, T. S., Halbritter, F., Zhang, M., Rendeiro, A. F., Perenthaler, E., Bock, C., & Chambers, I. (2018). Functional dissection of the enhancer repertoire in human embryonic stem cells. Cell stem cell, 23(2), 276-288.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Sahakyan, A., Clement, K., Clowers, K. J., Erickson, A. R., Shioda, K., Gygi, S. P., ... & Hochedlinger. K. Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nature Methods. 15, 732–740.
*CHIR99021, PD0325901, GO6983, Y27632, IM12, SB590885, WH4-023 .. from Axon Medchem
 
Senís, E., Mosteiro, L., Wilkening, S., Wiedtke, E., Nowrouzi, A., Afzal, S., ... & Grimm, D (2018). AAVvector-mediated in vivo reprogramming into pluripotency. Nature communications, 9(1), 2651.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Mor, N., Rais, Y., Sheban, D., Peles, S., Aguilera-Castrejon, A., Zviran, A., ... & Zerbib, M. (2018). Neutralizing Gatad2a-Chd4-Mbd3/NuRD complex facilitates deterministic induction of naive pluripotency. Cell stem cell, 23(3), 412-425.
* CHIR99021, PD0325901, GO6983, CGP77675, Y27632, DBZ from Axon Medchem
 
Oura, S., Miyata, H., Noda, T., Shimada, K., Matsumura, T., Morohoshi, A., ... & Ikawa, M. (2018). Chimeric analysis with newly established EGFP/DsRed2-tagged ES cells identify HYDIN as essential for spermiogenesis in mice. Experimental animals, 18-0071.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Martin Gonzalez, J., Baudet, A., Abelechian, S., Bonderup, K., d'Altri, T., Porse, B., ... & Cammenga, J. (2018). A new genetic tool to improve immune‐compromised mouse models: Derivation and CRISPR/Cas9‐mediated targeting of NRG embryonic stem cell lines. genesis, 56(9), e23238.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Trixl, L., Amort, T., Wille, A., Zinni, M., Ebner, S., Hechenberger, C., ... & Piatti, P. (2018). RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity. Cellular and molecular life sciences, 75(8), 1483-1497.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Skvortsova, E. V., Sinenko, S. A., & Tomilin, A. N. (2018). Immortalized murine fibroblast cell lines are refractory to reprogramming to pluripotent state. Oncotarget, 9(81), 35241.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Todaro, F., Campolo, F., Barrios, F., Pellegrini, M., Di Cesare, S., Tessarollo, L., ... & Dolci, S. (2018). Regulation of Kit expression in early mouse embryos and ES cells. STEM CELLS.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Kamenova, I., Mukherjee, P., Conic, S., Mueller, F., El-Saafin, F., Bardot, P., ... & Vincent, S. D. (2018). Co-translation drives the assembly of mammalian nuclear multisubunit complexes. bioRxiv, 419812.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Foster, B. M., Stolz, P., Mulholland, C. B., Montoya, A., Kramer, H., Bultmann, S., & Bartke, T. (2018). Critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin. Molecular cell, 72(4), 739-752.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
HUCH ORTEGA, Meritxell; CAROLUS, Johannes. LIVER ORGANOID, USES THEREOF AND CULTURE METHOD FOR OBTAINING THEM. U.S. Patent Application No 15/665,363, 2018.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Mulholland, C. B., Traube, F. R., Parsa, E., Eckl, E. M., Schoenung, M., Modic, M., ... & Bultmann, S. (2018). Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency. bioRxiv, 281519.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Mulholland, C. B., Ryan, J., Qin, W., Bartoschek, M. D., Traube, F. R., Parsa, E., ... & Leonhardt, H. (2018). TET1 drives global DNA demethylation via DPPA3-mediated inhibition of maintenance methylation. bioRxiv, 321604.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
SHOJI, Masanobu. Method for producing dopaminergic neurons. U.S. Patent Application No 10/017,734, 2018.
*CHIR99021, LDN193189, SU5402, SB431542, PD184352, PD173074 ... from Axon Medchem   PD0325901???
 
Song, J., Janiszewski, A., De Geest, N., Vanheer, L., Talon, I., Oh, T., & Pasque, V. (2018). X Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA
Methylation Levels. bioRxiv, 291450.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Sutherland, L., Ruhe, M., Gattegno-Ho, D., Mann, K., Greaves, J., Koscielniak, M., ... & Tsakiridis, A. (2018). LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein. J Cell Sci, jcs-222257.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Nett, I. R., Mulas, C., Gatto, L., Lilley, K. S., & Smith, A. (2018). Negative feedback via RSK modulates Erk‐dependent progression from naïve pluripotency. EMBO reports, e45642.
*CHIR99021, PD0325901, BI-D1870 from Axon Medchem
 
Lynch, CJ. Bernad, R, Calvo, I, Nobrega-Pereira, S, Ruiz, S, Ibarz, N, Martinez-Val, A. Gran-Castro, O, Gomez-Lopez, G, s-Leo´ n, EA, Angarica, VE, del Sol, A, Ortega, S, Fernandez-Capetillo, O.Rojo, E, Munoz, J and Serrano, M. The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity. Cell Reports 22, 2018, 396–410. 
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
El-Saafin, F., Curry, C., Ye, T., Garnier, J. M., Kolb-Cheynel, I., Stierle, M., ... & Tora, L. (2018). Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription. Human molecular genetics, 27(12), 2171-2186.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
SATO, Toshiro; CLEVERS, Johannes C.; HUCH ORTEGA, Meritxell. CULTURE MEDIUM FOR EPITHELIAL STEM CELLS AND ORGANOIDS COMPRISING THE STEM CELLS. U.S. Patent Application No 15/654,243, 2018.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Mor, N., Rais, Y., Peles, S., Sheban, D., Aguilera-Castrejon, A., Zviran, A., ... & Zerbib, M. (2018). Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. bioRxiv, 192781.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Messemaker, T. C., Leeuwen, S. M., Berg, P. R., EJ‘t Jong, A., Palstra, R. J., Hoeben, R. C., ... & Mikkers, H. M. (2018). Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot. Scientific reports, 8(1), 386.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., ... & Tamai, Y. (2018). The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles. Disease models & mechanisms, 11(1), dmm028779.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Kilens, S., Meistermann, D., Moreno, D., Chariau, C., Gaignerie, A., Reignier, A., ... & Flippe, L. (2018). Parallel derivation of isogenic human primed and naive induced pluripotent stem cells. Nature communications, 9(1), 360.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
de Jesus, B. B., Marinho, S. P., Barros, S., Sousa-Franco, A., Alves-Vale, C., Carvalho, T., & Carmo-Fonseca, M. (2018). Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency. Nature communications, 9(1), 94.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Angarica, V. E., del Sol, A., Ortega, S., Fernandez-Capetillo, O., Rojo, E., Munoz, J., & Serrano, M. The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Mor, N., Rais, Y., Peles, S., Sheban, D., Aguilera-Castrejon, A., Zviran, A., ... & Zerbib, M. (2018). Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. bioRxiv, 192781.
*2i: CHIR99021 and PD0325901 from Axon Medchem
 
Conic, S., Desplancq, D., Ferrand, A., Fischer, V., Heyer, V., San Martin, B. R., ... & Weiss, E. (2018). Imaging of native transcription factors and histone phosphorylation at high resolution in live cells. J Cell Biol, 217(4), 1537-1552.
 
Nett, I. R., Mulas, C., Gatto, L., Lilley, K. S., & Smith, A. (2018). Negative feedback via RSK modulates Erk‐dependent progression from naïve pluripotency. EMBO reports, 19(8), e45642.
* BI-D1870, CHIR99021 and PD0325901 from Axon Medchem
 
2017  (35 citations)
HIRABAYASHI, M., HARA, H., GOTO, T., TAKIZAWA, A., DWINELL, M. R., YAMANAKA, T., ... & NAKAUCHI, H. (2017). Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts. Journal of Reproduction and Development, 63(6), 611-616.
2i: CHIR99021 and PD0325901 from Axon Medchem
 
Trixl, L., Amort, T., Wille, A., Zinni, M., Ebner, S., Hechenberger, C., ... & Piatti, P. (2017). RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity. Cellular and Molecular Life Sciences, 1-15.
2i: CHIR99021 and PD0325901 from Axon Medchem
 
Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., ... & Tamai, Y. (2018). The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles. Disease models & mechanisms, 11(1), dmm028779.
2i: CHIR99021 and PD0325901 from Axon Medchem
 
Messemaker, T. C., Leeuwen, S. M., Berg, P. R., EJ‘t Jong, A., Palstra, R. J., Hoeben, R. C., ... & Mikkers, H. M. (2018). Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot. Scientific reports, 8(1), 386.
2i: CHIR99021 and PD0325901 from Axon Medchem
 
Karg, E., Smets, M., Ryan, J., Forné, I., Qin, W., Mulholland, C. B., ... & Leonhardt, H. (2017). Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells. Journal of molecular biology, 429(24), 3814-3824.
2i: CHIR99021 and PD0325901 from Axon Medchem
 
WANG, Jichang; IZSVÁK, Zsuzsanna; HURST, Laurence Daniel. Endogenous retrovirus transcription as a marker for primate naive pluripotent stem cells. U.S. Patent Application No 15/517,904, 2017.
*CHIR99021, PD0325901, SB2020190 from Axon Medchem
 
de Jesus, B. B., Marinho, S. P., Barros, S., Sousa-Franco, A., Alves-Vale, C., Carvalho, T., & Carmo-Fonseca, M. (2018). Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency. Nature communications, 9(1), 94.
2i: CHIR99021 and PD0325901 were purchased from Axon Medchem
 
HANNA, Yaqub; NOVERSHTERN, Noa; RAIS, Yoach. Media for culturing pluripotent stem cells. U.S. Patent Application No 15/500,163, 2017.
*CHIR99021, BIO, PD0325901, PD98059, PD184352, BAY43-9006, Thiazovivin, CGP77675, DAPT, DBZ, LY2886762, RU-SKI43, LDN193189, K02288, Dosomorphine, BIRB796, AEG3482, SB203580, SB202190, LY 2228820, PD169316 etc. from Axon Medchem
 
ORTEGA, Meritxell Huch; CLEVERS, Johannes Carolus. Liver organoid, uses thereof and culture method for obtaining them. U.S. Patent No 9,765,301, 2017.
2i: CHIR99021 and PD0325901 from Axon Medchem
 

Yamaguchi, T., Sato, H., Kato-Itoh, M., Goto, T., Hara, H., Sanbo, M., ... & Ota, Y. (2017). Interspecies organogenesis generates autologous functional islets. Nature, 542(7640), 191-196.
https://www.nature.com/nature/journal/v542/n7640/abs/nature21070.html
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Kawamata, M., Katsuda, T., Yamada, Y., & Ochiya, T. (2017). In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules. Biochemical and Biophysical Research Communications, 482(4), 750-757.
See: http://www.sciencedirect.com/science/article/pii/S0006291X16319805
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Nigro, A. L., Prosper, F., & Aranguren, X. L. (2017). Generation of a Sprague-Dawley-GFP rat iPS cell line. Stem Cell Research. 2017, 21, 47-50.
https://www.researchgate.net/profile/Antonio_Lo_Nigro/publication/316029625_Generation_of_a_Sprague-Dawley-GFP_rat_iPS_cell_line/links/58f770f6aca272649886fda3/Generation-of-a-Sprague-Dawley-GFP-rat-iPS-cell-line.pdf
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Stryjewska, A., Dries, R., Pieters, T., Verstappen, G., Conidi, A., Coddens, K., ... & van Grunsven, L. A. (2017). Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells. Stem Cells, 35(3), 611-625.
See: http://onlinelibrary.wiley.com/doi/10.1002/stem.2521/full
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Coppiello, G., Abizanda, G., Aguado, N., Iglesias, E., Iglesias-Garcia, O., Nigro, A. L., ... & Aranguren, X. L. (2017). Generation of a Sprague-Dawley-GFP rat iPS cell line. Stem Cell Research. 21, 40-43.
See: http://www.sciencedirect.com/science/article/pii/S187350611730065X
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Coppiello, G., Abizanda, G., Aguado, N., Iglesias, E., Iglesias-Garcia, O., Nigro, A. L., ... & Aranguren, X. L. (2017). Isolation and characterization of Sprague-Dawley and Wistar Kyoto GFP rat embryonic stem cells. Stem Cell Research. 21, 47-50.
See: http://www.sciencedirect.com/science/article/pii/S1873506117300648
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Tosti, L., Ashmore, J., Tan, B. S. N., Carbone, B., Mistri, T. K., Wilson, V., ... & Kaji, K. (2017). Mapping transcription factor occupancy using minimal numbers of cells in vitro and in vivo. bioRxiv, 158931.
http://www.biorxiv.org/content/early/2017/07/03/158931.full.pdf+html
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Ludwig, A. K., Zhang, P., Hastert, F. D., Meyer, S., Rausch, C., Herce, H. D., ... & Storm, C. (2017). Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise. Nucleic acids research, 45(5), 2438-2457.
https://academic.oup.com/nar/article/45/5/2438/2638395/Binding-of-MBD-proteins-to-DNA-blocks-Tet1
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Pieters, T., Haenebalcke, L., Bruneel, K., Vandamme, N., Hochepied, T., van Hengel, J., ... & Goossens, S. (2017). Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange. JoVE (Journal of Visualized Experiments), (122), e55575-e55575.
https://www.jove.com/video/55575/structure-function-studies-mouse-embryonic-stem-cells-using
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Zhang, P., Rausch, C., Hastert, F. D., Boneva, B., Filatova, A., Patil, S. J., ... & Cardoso, M. C. (2017). Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. Nucleic Acids Research.
https://academic.oup.com/nar/article/3752492
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Ziegenhain, C., Vieth, B., Parekh, S., Reinius, B., Guillaumet-Adkins, A., Smets, M., ... & Enard, W. (2017). Comparative analysis of single-cell RNA sequencing methods. Molecular cell, 65(4), 631-643.
http://www.sciencedirect.com/science/article/pii/S1097276517300497
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Katsuda, T., Kawamata, M., Hagiwara, K., Takahashi, R. U., Yamamoto, Y., Camargo, F. D., & Ochiya, T. (2017). Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity. Cell stem cell, 20(1), 41-55.
http://www.sciencedirect.com/science/article/pii/S1934590916303472
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Anton, T., & Bultmann, S. (2017). Site-specific recruitment of epigenetic factors with a modular CRISPR/Cas system. Nucleus, 1-8.
http://www.tandfonline.com/doi/full/10.1080/19491034.2017.1292194?scroll=top&needAccess=true
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Barakat, T. S., Halbritter, F., Zhang, M., Rendeiro, A. F., Bock, C., & Chambers, I. (2017). Functional dissection of the enhancer repertoire in human embryonic stem cells. bioRxiv, 146696.
http://www.biorxiv.org/content/early/2017/07/04/146696.full.pdf+html
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Thanisch, K., Song, C., Engelkamp, D., Koch, J., Wang, A., Hallberg, E., ... & Solovei, I. (2017). Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering. Differentiation, 94, 58-70.
http://www.sciencedirect.com/science/article/pii/S0301468116301116
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., ... & Van Laake, L. W. (2017). Circadian networks in human embryonic stem cell‐derived cardiomyocytes. EMBO reports, e201743897.
http://www.sciencedirect.com/science/article/pii/S2213671116303009
(2i: CHIR99021 and PD0325901 from Axon Medchem)

A. L. Nigro,* A. de Jaime-Soguero, R. Khoueiry, D. S. Cho, G. M. Ferlazzo, I. Perini, V. A. Escalona, X. L. Aranguren, S.M.C. de Sousa Lopes, K. P. Koh, P. Giulio Conaldi, W.-S. Hu, A. Zwijsen, F. Lluis, & C.M. Verfaillie.
PDGFRa+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors.
http://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(16)30300-9
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Zhang, P., Ludwig, A. K., Hastert, F. D., Rausch, C., Lehmkuhl, A., Hellmann, I., ... & Cardoso, M. C. (2017). L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins. Nucleus, (May 2017 accepted), 1-15.
http://www.tandfonline.com/doi/abs/10.1080/19491034.2017.1330238
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Amort, T., Rieder, D., Wille, A., Khokhlova-Cubberley, D., Riml, C., Trixl, L., ... & Lusser, A. (2017). Distinct 5-methylcytosine profiles in poly (A) RNA from mouse embryonic stem cells and brain. Genome biology, 18(1), 1.
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1139-1
(2i: CHIR99021 and PD0325901 from Axon Medchem)

HIRABAYASHI, M., HARA, H., GOTO, T., TAKIZAWA, A., DWINELL, M. R., YAMANAKA, T., ... & NAKAUCHI, H. (2017). Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts. Journal of Reproduction and Development, 2017-074.
https://www.jstage.jst.go.jp/article/jrd/advpub/0/advpub_2017-074/_article
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Gonen, N., Quinn, A., O’Neill, H. C., Koopman, P., & Lovell-Badge, R. (2017). Normal levels of Sox9 expression in the developing mouse testis depend on the TES/TESCO enhancer, but this does not act alone. PLoS genetics, 13(1), e1006520.
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006520
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Nigro, A. L., de Jaime-Soguero, A., Khoueiry, R., Cho, D. S., Ferlazzo, G. M., Perini, I., ... & Conaldi, P. G. (2017). PDGFRα+ cells in embryonic stem cell cultures represent the in vitro equivalent of the pre-implantation primitive endoderm precursors. Stem cell reports, 8(2), 318-333.
http://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(16)30300-9
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Oginuma, M., Moncuquet, P., Xiong, F., Karoly, E., Chal, J., Guevorkian, K., & Pourquié, O. (2017). A gradient of glycolytic activity coordinates FGF and Wnt signaling during elongation of the body axis in amniote embryos. Developmental Cell, 40(4), 342-353.
http://www.sciencedirect.com/science/article/pii/S1534580717300709

Keränen, T., Hömmö, T., Moilanen, E., & Korhonen, R. (2017). β 2-receptor agonists salbutamol and terbutaline attenuated cytokine production by suppressing ERK pathway through cAMP in macrophages. Cytokine, 94, 1-7.
http://www.sciencedirect.com/science/article/pii/S1043466616301831

Lopez-Guerrero, A. M., Tomas-Martin, P., Pascual-Caro, C., Macartney, T., Rojas-Fernandez, A., Ball, G., ... & Martin-Romero, F. J. (2017). Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains. Scientific Reports, 7.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428229/

Oginuma, M., Moncuquet, P., Xiong, F., Karoly, E., Chal, J., Guevorkian, K., & Pourquie, O. (2017). Warburg-like metabolism coordinates FGF and Wnt signaling in the vertebrate embryo. bioRxiv, 101451.
http://www.biorxiv.org/content/early/2017/01/18/101451

2016
Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., ... & Izsvák, Z. (2016). Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression. Nature protocols, 11(2), 327.
https://search.proquest.com/openview/5fa41bab6023e5205eeb19213abd4edb/1?pq-origsite=gscholar&cbl=536306
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Weiner, A., Lara-Astiaso, D., Krupalnik, V., Gafni, O., David, E., Winter, D. R., ... & Amit, I. (2016). Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution. Nature biotechnology, 34(9), 953-961.
https://www.researchgate.net/profile/Jacob_Hanna/publication/305635990_Co-ChIP_enables_genome-wide_mapping_of_histone_mark_co-occurrence_at_single-molecule_resolution/links/579649b308ae33e89fad81d5.pdf
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Katayama, M., Hirayama, T., Horie, K., Kiyono, T., Donai, K., Takeda, S., ... & Fukuda, T. (2016). Induced pluripotent stem cells with six reprogramming factors from prairie vole, which is an animal model for social behaviors. Cell transplantation, 25(5), 783-796.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
C Hirsch et al. Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants. 
Arch Toxicol. 2016 Feb 29. [Epub ahead of print]
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
C. Ziegenhain et al. Comparative analysis of single-cell RNA-sequencing methods.
bioRxiv (2016): 035758.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
B.C.Heng et al. An overview of protocols for the neural induction of dental and oral stem cells in vitro.
Tissue Eng Part B Rev. 2016 Jan 12.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
Chang, W. F., Hwu, Y. M., Xu, J., Lin, C. J., Wang, S. W., Cheng, A. S., ... & Sung, L. Y. (2016). Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells. PloS one, 11(11), e0165715.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
Takemoto, N., Yoshimura, T., Miyazaki, S., Tashiro, F., & Miyazaki, J. I. (2016). Gtsf1l and Gtsf2 Are Specifically Expressed in Gonocytes and Spermatids but Are Not Essential for Spermatogenesis. PloS one, 11(3), e0150390.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
Iseki, H., Nakachi, Y., Hishida, T., Yamashita‐Sugahara, Y., Hirasaki, M., Ueda, A., ... & Takahashi, S. (2016). Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells, 34(2), 322-333.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
Ochiya, Takahiro, and Masaki Kawamata. "Chimeric rat produced using rat embryonic stem cells in the presence of an ES cell differentiation suppressant." U.S. Patent No. 9,309,537. 12 Apr. 2016.
(CHIR98014, CHIR99021, PD0325901 and GSK269962A from Axon Medchem)
 
Vila-Cejudo, M., Massafret, O., Ibáñez, E., & Santaló, J. (2016). Efficient derivation of embryonic stem cells from mouse B6CBAF1 blastocysts. Animal Reproduction, 13(3), 692-692.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
Freed, William J., and Chun-Ting Lee. "Three-dimensional model of human cortex." U.S. Patent Application No. 15/136,250.
 
Nairismägi, M. L., Tan, J., Lim, J. Q., Nagarajan, S., Ng, C. C. Y., Rajasegaran, V., ... & Li, Z. M. (2016). JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma. Leukemia, 30(6), 1311.
(PD0325901, Trametinib, Gefitinib from Axon Medchem)
 
Lin, J., Khan, M., Zapiec, B., & Mombaerts, P. (2016). Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos. Scientific reports, 6.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
Gennet, N., Tamburini, C., Nan, X., & Li, M. (2016). FolR1: a novel cell surface marker for isolating midbrain dopamine neural progenitors and nascent dopamine neurons. Scientific reports, 6, 32488.
 
Vila-Cejudo, M., Ibáñez, E., & Santaló, J. (2016). Culture optimization to obtain mouse embryonic stem cell lines from single blastomeres. Animal Reproduction, 13(3), 691-691.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
Balvís, N. F., Lorenzo, P. L., Gutiérrez-Adán, A., Rebollar, P. G., Avilés, M., & Bermejo-Álvarez, P. (2016). Optimization of RNA concentration for genome editing by CRISPR in rabbit zygotes. Anim. Reprod, 13(3), 683.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
Weiner, A., Lara-Astiaso, D., Krupalnik, V., Gafni, O., David, E., Winter, D. R., ... & Amit, I. (2016). Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution. Nature biotechnology, 34(9), 953-961.
(2i: CHIR99021 and PD0325901 from Axon Medchem)
 
MICHELLE, PEK MI XUE. INVESTIGATION OF RAS-DEPENDENT GENE EXPRESSION & CELL SURVIVAL SIGNALLING IN COLORECTAL CANCER. 2016. PhD Thesis.
(Palbociclib and PD0325901 from Axon Medchem)
 
Wu, H., Thijssen, P. E., de Klerk, E., Vonk, K. K., Wang, J., den Hamer, B., ... & Daxinger, L. (2016). Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals. Human molecular genetics, 25(18), 4041-4051.
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Takemoto, Noriaki, et al. "Gtsf1l and Gtsf2 Are Specifically Expressed in Gonocytes and Spermatids but Are Not Essential for Spermatogenesis." PloS one 11.3 (2016): e0150390.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150390
2i:CHIR99021 and PD0325901 from Axon Medchem


Meek, Stephen, et al. "Reduced levels of dopamine and altered metabolism in brains ofHPRTknock-out rats: a new rodent model of Lesch-Nyhan Disease." Scientific reports 6 (2016): 25592.
www.nature.com/articles/srep25592

Wang, J., Singh, M., Sun, C., Besser, D., Prigione, A., Ivics, Z., ... & Izsvák, Z. (2016). Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression. Nature Protocols, 11(2), 327-346.
http://www.nature.com/nprot/journal/v11/n2/abs/nprot.2016.016.html
2i:CHIR99021 and PD0325901 from Axon Medchem 

Haagensen, Emma J., et al. "Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent." European Journal of Cancer 56 (2016): 69-76.
http://www.sciencedirect.com/science/article/pii/S0959804915011569

Nairismägi, M. L., et al. "JAK-STATand G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma." Leukemia (2016).
http://www.nature.com/leu/journal/vaop/ncurrent/full/leu201613a.html
PD0325901, GSK 1120212 and ZD 1839 from Axon Medchem

Sudheer, S., Liu, J., Marks, M., Koch, F., Anurin, A., Scholze, M., ... & Herrmann, B. G. (2016). Different concentrations of FGF ligands, FGF2 or FGF8 determine distinct states of WNT‐induced presomitic mesoderm. Stem Cells, 34(7), 1790-1800.
http://onlinelibrary.wiley.com/doi/10.1002/stem.2371/full
(2i: CHIR99021 and PD0325901 from Axon Medchem)

Carbognin, Elena, et al. "Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency." The EMBO journal (2016): e201592629.
http://emboj.embopress.org/content/early/2016/02/22/embj.201592629.abstract
2i:CHIR99021 and PD0325901 from Axon Medchem

Sancho-Martinez, Ignacio, et al. "Establishment of human iPSC-based models for the study and targeting of glioma initiating cells." Nature communications 7 (2016).
http://www.nature.com/ncomms/2016/160222/ncomms10743/full/ncomms10743.html
2i:CHIR99021 and PD0325901 from Axon Medchem

2015
Kawano, Haruna, et al. "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." Oncology reports 34.5 (2015): 2251-2258.
https://www.spandidos-publications.com/or/34/5/2251?text=fulltext
2i:CHIR99021 and PD0325901 from Axon Medchem

Perini, Ilaria, et al. "Myogenic induction of adult and pluripotent stem cells using recombinant proteins." Biochemical and biophysical research communications 464.3 (2015): 755-761.
http://www.sciencedirect.com/science/article/pii/S0006291X15302539
2i:CHIR99021 and PD0325901 from Axon Medchem

Murayama, Hideyuki, et al. "Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin." Stem cell reports 4.1 (2015): 103-113.
http://www.sciencedirect.com/science/article/pii/S2213671114003609
2i:CHIR99021 and PD0325901 from Axon Medchem

Iseki, Hiroyoshi, et al. "Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells."STEMCELLS (2015).
http://onlinelibrary.wiley.com/doi/10.1002/stem.2243/full
2i:CHIR99021 and PD0325901 from Axon Medchem

Yanagida, Ayaka, et al. "Liver maturation deficiency in p57Kip2−/− mice occurs in a hepatocytic p57 Kip2 expression-independent manner."  Developmental biology 407.2 (2015): 331-343.
http://www.sciencedirect.com/science/article/pii/S0012160615300373
2i:CHIR99021 and PD0325901 from Axon Medchem

Huijbers, I. J., Del Bravo, J., Ali, R. B., Pritchard, C., Braumuller, T. M., van Miltenburg, M. H., ... & Jonkers, J. (2015). Using the GEMM-ESCstrategy to study gene function in mouse models. Nature protocols, 10(11), 1755-1785.
http://www.nature.com/nprot/journal/v10/n11/abs/nprot.2015.114.html
2i:CHIR99021 and PD0325901 from Axon Medchem

Lieske, Nora V., et al. "Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors." PloS one 10.11 (2015): e0141903.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141903
2i: PD0325901 from Axon Medchem

Kawakami, Eri, et al. "The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators." Mechanisms of development 135 (2015): 31-42.
http://www.sciencedirect.com/science/article/pii/S0925477314000677
2i:CHIR99021 and PD0325901 from Axon Medchem

Kamiya, Akihide, et al. "MEK-ERK Activity Regulates the Proliferative Activity of Fetal Hepatoblasts Through Accumulation of p16/19cdkn2a." Stem cells and development 24.21 (2015): 2525-2535.
http://online.liebertpub.com/doi/abs/10.1089/scd.2015.0015
2i:CHIR99021 and PD0325901 from Axon Medchem

Welling, Maaike, et al. "DAZL regulates Tet1 translation in murine embryonic stem cells." EMBO reports 16.7 (2015): 791-802.
http://embor.embopress.org/content/16/7/791

Tabata, Yoshikuni, et al. "Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells." Journal of Biomolecular Screening 20.9 (2015): 1074-1083.
http://jbx.sagepub.com/content/20/9/1074.short
*CHIR99021, PD0325901 and LDN193189 from Axon Medchem

piggyBac Transposon-Based Insertional Mutagenesis in Mouse Haploid Embryonic Stem Cells.
Pettitt, S. J., Tan, E. P., & Yusa, K. (2015).
Methods Mol Biol. 2015;1239:15-28. doi: 10.1007/978-1-4939-1862-1_2.
2i: CHIR99021 and PD0325901 from Axon Medchem

DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes.
Cohen, I. S., Bar, C., Paz-Elizur, T., Ainbinder, E., Leopold, K., de Wind, N., ... & Livneh, Z.
Nucleic acids research, 2015, 43(3), 1637-1645.
2i: CHIR99021 and PD0325901 from Axon Medchem

Establishment of Tsc2‑deficient rat embryonic stem cells.
Ito, Y., Kawano, H., Kanai, F., Nakamura, E., Tada, N., Takai, S., ... & Hino, O.
International journal of oncology, 2015, 46(5), 1944-1952.
2i: CHIR99021 and PD0325901 from Axon Medchem

Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.
Yang, J., Wang, W., Ooi, J., Campos, L. S., Lu, L., & Liu, P.
Stem Cells. 2015 May;33(5):1390-404. doi: 10.1002/stem.1926.
2i: CHIR99021 and PD0325901 from Axon Medchem

Establishment and Use of Mouse Haploid ES Cells.
Leeb, M., Perry, A. C., & Wutz, A.
Current Protocols in Mouse Biology, 2015, 155-185.
2i: CHIR99021 and PD0325901 from Axon Medchem

Embryonic stem cell differentiation requires full length Chd1.
Piatti, P., Lim, C. Y., Nat, R., Villunger, A., Geley, S., Shue, Y. T., ... & Lusser, A.
Sci Rep. 2015 Jan 26;5:8007. doi: 10.1038/srep08007.
2i: CHIR99021 and PD0325901 from Axon Medchem

Functional Compensation Between Myc and PI3K Signaling Supports Self‐Renewal of Embryonic Stem Cells.
Hishida, T., Nakachi, Y., Mizuno, Y., Katano, M., Okazaki, Y., Ema, M., ... & Okuda, A.
Stem Cells, 2015, 33(3), 713-725.
2i: CHIR99021 and PD0325901 from Axon Medchem

Phospho-STIM1 is a downstream effector that mediates the signaling triggered by IGF-1 in HEK293 cells.
Tomas-Martin, P., Lopez-Guerrero, A. M., Casas-Rua, V., Pozo-Guisado, E., & Martin-Romero, F. J.
Cellular signalling, 2015, 27(3), 545-554.

STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration.
Casas-Rua, V., Tomas-Martin, P., Lopez-Guerrero, A. M., Alvarez, I. S., Pozo-Guisado, E., & Martin-Romero, F. J.
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2015, 1853(1), 233-243.

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.
Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, et al.
PLoS Genet 11(5): e1005239. doi:10.1371/journal.pgen.1005239
*3i: SB431542, CHIR99021 and PD0325901 from Axon Medchem

Funktionelle Analyse der Histon-Demethylase UTX in hämatopoetisch differenzierenden murinen ES-Zellen.
Kampka, J. (2015).
Doctoral dissertation of Julius-Maximilians-Universität Würzburg.
2i: CHIR99021 and PD0325901 from Axon Medchem

2014 (total 23 citations)
Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation.
de Esch, C. E., Ghazvini, M., Loos, F., Schelling-Kazaryan, N., Widagdo, W., Munshi, S. T., ... & Willemsen.
Stem Cell Reports. 2014, 3, 548–555.
* PD0325901 (1μM, ERK1/2i, Axon 1408); CHIR99021 (3μM, GSK3i, Axon 1386); SB203580 (10 μM, p38i, Axon 1363) Y-27632 (5μM, Axon 1683) from Axon Medchem.

Pharmacological suppression of the Ras/MAPK pathway in thyroid carcinoma cells can provoke opposite effects on cell migration and proliferation: The appearance of yin-yang effects and the need of combinatorial treatments.
Glassmann, A., Winter, J., Kraus, D., Veit, N., & Probstmeier, R.
International journal of oncology, 2014, 45(6), 2587-2595. 

Erk Signaling Suppresses Embryonic Stem Cell SelfRenewal to Specify Endoderm.
Hamilton, W. B., & Brickman, J. M.
Cell report, 2014, 9(6), 2056–2070.
2i: CHIR99021 and PD0325901 from Axon Medchem

A conserved role for non-neural ectoderm cells in early neural development.
Cajal, M., Creuzet, S. E., Papanayotou, C., Sabéran-Djoneidi, D., de Sousa Lopes, S. M. C., Zwijsen, A., ... & Camus, A.
Development, 2014, 141(21), 4127-4138. 

Compounds and compositions as protein kinase inhibitors.
Costales, A. Q., Huang, S., Jin, J. X., Liu, Z., Pecchi, S., Poon, D., ... & Zhang, Q. (2014).
U.S. Patent No. 8,859,548.
*PD0325901 and other 11 drugs from Axon Medchem, including PD184352, SL327, LY294002, PI103, PIK75, PIK90, GDC0941, BEZ235, AS252424 and TGX221.

Gene Targeting Study Reveals Unexpected Expression of Brain expressed X-linked 2 in Endocrine and Tissue Stem/progenitor Cells in Mice.
K Ito, S Yamazaki, R Yamamoto, Y Tajima, A Yanagida, T Kobayashi, M Kato-Itoh, S Kakuta, Y Iwakura, H Nakauchi and A Kamiya*.
J Biol Chem. 2014 Oct 24;289(43):29892-911. doi: 10.1074/jbc.M114.580084.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) were procured from Axon Medchem.  

CULTURE MEDIA FOR STEM CELLS.
JC Clevers, T Sato, M Huch Ortega, W Richard.
US Patent Application 20140243227.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) are procured from Axon Medchem  

Identifying Nuclear Protein–Protein Interactions Using GFP Affinity Purification and SILAC-Based Quantitative Mass Spectrometry.
HI Baymaz, CG Spruijt, M Vermeulen.
Methods in Molecular Biology 2014, 1188, 207-226.
2i inhibitors (Axon Medchem, CHIR99021 and PD0325901)  

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer.
AR Palla, D Piazzolla, M Abad, H Li, O Dominguez, HB Schonthaler, EF Wagner and M Serrano.
Oncogene 2014, 33, 2513–2519.
2i: CHIR99021 and PD0325901 from Axon Medchem  

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.
D Piazzolla, AR Palla, C Pantoja, M Cañamero… & M Serrano*.
Nat Commun. 2014 Jun 30;5:4226. doi: 10.1038/ncomms5226.
*2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) are procured from Axon Medchem.  

Homologous Recombination Efficiency Enhanced by Inhibition of MEK and GSK3β.
Z Lin, Y Zhang, T Gao, L Wang, Q Zhang, J Zhou, J Zhao.
Genesis, 2014, in press. DOI: 10.1002/dvg.22821

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation.
U Müller, C Bauer, M Siegl, A Rottach, H Leonhardt*
Nucleic Acids Res. 2014 Jul;42(13):8592-604. doi: 10.1093/nar/gku552. 
2i: PD0325901 (Axon 1408) and CHIR99021 (Axon 1386) 

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
T Pfaffeneder, F Spada, M Wagner, C Brandmayr, SK Laube, D Eisen, M Truss, J Steinbacher, ....
Nat Chem Biol. 2014 Jul;10(7):574-81. doi: 10.1038/nchembio.1532.

Citrullination regulates pluripotency and histone H1 binding to chromatin.
MA Christophorou, G Castelo-Branco, RP Halley-Stott, CS Oliveira, R Loos, A Radzisheuskaya, KA Mowen, P Bertone, JCR Silva, M Zernicka-Goetz, ML Nielsen, JB Gurdon & T Kouzarides.
Nature 507, 104–108 (06 March 2014) doi:10.1038/nature12942
*both PD0325901 and CHIR99021 from Axon Medchem

Formation of a Polarised Primitive Endoderm Layer in Embryoid Bodies Requires Fgfr/Erk Signalling.
G Doughton, J Wei, N Tapon, MJ Welham, AD Chalmers.
PLOS ONE, 2014, 9(4): e95434. doi:10.1371/journal.pone.0095434

FIREWACh: High-throughput Functional Detection of Transcriptional Regulatory Modules in Mammalian Cells.
M Murtha, Z Tokcaer-Keskin, Z Tang, F Strino, X Chen, Y Wang, X Xi, C Basilico, S Brown, R Bonneau, Y Kluger, and L Dailey.
Nat Methods. 2014 May;11(5):559-65. doi: 10.1038/nmeth.2885.
*2i, PD0325901, 1 μM and CHIR99021, 3 μM from Axon Medchem 

T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signaling responses.
SS. Skånland, K Moltu, T Berge, EM Aandahl and K Taskén
Biochem J. 2014 Jun 15;460(3):399-410. doi: 10.1042/BJ20140040.

Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells.
IJ Huijbers, RB Ali, C Pritchard, M Cozijnsen, MCh Kwon, N Proost, JY Song, H de Vries, J Badhai, K Sutherland, P Krimpenfort, EM Michalak, J Jonkers, A Berns.
EMBO J. 2014, online. DOI: 10.1002/emmm.201303297 | Published 08.01.2014.
2i, PD0325901 and CHIR99021 from Axon Medchem

Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
D Smeets, Y Markaki, VJ Schmid, F Kraus, Anna Tattermusch, A Cerase, M Sterr, S Fiedler, J Demmerle, J Popken, H Leonhardt, N Brockdorff, T Cremer, L Schermelleh, and M Cremer.
Epigenetics & Chromatin 2014, 7, 8.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) from Axon Medchem 

Rapid identification of targeted transgene integrations in ES cells by fluorescence detection.
S Kautschitsch, L Andersen, S Hammerschmid, & T Rülicke.
Transgenic Res. 2014 Jun;23(3):469-75. doi: 10.1007/s11248-014-9782-3.
*2i (MEK inhibitor PD0325901, 1 μM and GSK3 inhibitor CHIR99021, 3 μM) from Axon Medchem 

T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signaling responses.
SS Skånland, K Moltu, T Berge, EM Aandahl and K Taskén.
Biochem J. 2014 Jun 15;460(3):399-410. doi: 10.1042/BJ20140040.

Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells.
I Ismailoglu, Q Chen, M Popowski, L Yang, SS Gross, AH Brivanlou.
Dev Biol. 2014 Jul 15;391(2):230-40. doi: 10.1016/j.ydbio.2014.04.005.

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.
Masouleh, B. K., Geng, H., Hurtz, C., Chan, L. N., Logan, A. C., Chang, M. S., ... & Müschen, M.
Proceedings of the National Academy of Sciences, 2014, 111(21), E2219-E2228. doi: 10.1073/pnas.1400958111
*STF-083010, AZD5363 and PD325901 were obtained from Axon Medchem

2013 (*23 publications in 2013)
Derivation of novel human ground state naive pluripotent stem cells.
O Gafni, L Weinberger, AA Mansour, YS Manor, E Chomsky, D Ben-Yosef, Y Kalma, S Viukov, ...& JH Hanna.
Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. 
*CHIR99021 (Axon 1386), PD0325901 (Axon 1408), SB202190 (Axon 1364), BIRB796 (Axon 1358), Y-27632 (Axon 1683) used in this study are procured from Axon Medchem. 

Identification of Ccr4-Not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
M Kamon, M Katano, K Hiraki-Kamon, T Hishida, Y Nakachi, Y Mizuno, Y Okazaki, A Suzuki, M Hirasaki, A Ueda, M Nishimoto, H Kato, and A Okuda.
Stem Cells Dev. 2014 Sep 15;23(18):2170-9. doi: 10.1089/scd.2013.0326.

Deterministic direct reprogramming of somatic cells to pluripotency. 
Y Rais, A Zviran, S Geula, O Gafni, E Chomsky, S Viukov, AA Mansour, I Caspi, V Krupalnik, ....& JH Hanna. 
Nature, 2013, 502 (7469), 65-70.

Targeting and tracing of specific DNA sequences with dTALEs in living cells. 
Thanisch, K., Schneider, K., Morbitzer, R., Solovei, I., Lahaye, T., Bultmann, S., & Leonhardt, H. 
Nucleic Acids Res. 2014 Apr;42(6):e38. doi: 10.1093/nar/gkt1348.
2i: PD0325901 and CHIR99021 from Axon Medchem

Inhibition of Stim1 Phosphorylation Underlies Resveratrol-Induced Inhibition of Store-Operated Calcium Entry.
V Casas-Rua, IS Álvarez, E Pozo-Guisado, FJ Martín-Romero.
Biochem Pharmacol. 2013 Dec 1;86(11):1555-63. doi: 10.1016/j.bcp.2013.09.018. 

The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.
A Kumar, T Torii, Y Ishino, D Muraoka, T Yoshimura, A Togayachi, H Narimatsu, K Ikenaka and S Hitoshi.
J Biol Chem. 2013 Oct 4;288(40):28859-68. doi: 10.1074/jbc.M113.469403.

PDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
J Tan, Z Li, PL Lee, P Guan, MY Aau, ST Lee, M Feng, CZ Lim, EYJ Lee, ZN Wee, YC Lim, RKM Karuturi and Q Yu.
Cancer Discov. 2013 Oct;3(10):1156-71. doi: 10.1158/2159-8290.CD-12-0595. 
... 60 inhibitors including PD0325901 were purchased from Axon Medchem 

Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer
AR Palla, D Piazzolla, M Abad, H Li, O Dominguez, HB Schonthaler, EF Wagner and M Serrano.
Oncogene. 2014 May 8;33(19):2513-9. doi: 10.1038/onc.2013.196.

Tuning of β‐catenin Activity is Required to Stabilise Self‐renewal of Rat Embryonic Stem Cells.
S Meek, J Wei, L Sutherland, B Nilges, M Buehr, SR Tomlinson, AJ Thomson, T Burdon.
Stem Cells. 2013 Oct;31(10):2104-15. doi: 10.1002/stem.1466.

Epigenetic regulation of lentiviral and retroviral vectors in murine embryonic stem (ES) cells and genetic modification of ES cells with lentiviral vectors for application in regenerative medicine.
TT LIM, 2013
PhD Thesis. Universitäts-und Landesbibliothek Bonn. (supervisors: A Pfeifer and DO Fürst)

Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules.
N Liu, M Wang, W Deng, CS Schmidt, W Qin, H Leonhardt, F Spada.
PLoS ONE 2013, 8(5): e62755. doi:10.1371/journal.pone.0062755

Reduced Oct4 Expression Directs a Robust Pluripotent State with Distinct Signaling Activity and Increased Enhancer Occupancy by Oct4 and Nanog.
V Karwacki-Neisius, J Göke, R Osorno, F Halbritter, JH Ng, AY Weiße, FCK Wong, A Gagliardi, NP Mullin, N Festuccia, D Colby, SR Tomlinson, HH Ng, I Chambers.
Cell Stem Cell 2013, 12(5), 531-545.

ERK2 Suppresses Self-Renewal Capacity of Embryonic Stem Cells, but Is Not Required for Multi-Lineage Commitment.
WB Hamilton, K Kaji, T Kunath.
PLoS ONE 2013, 8(4): e60907. doi:10.1371/journal.pone.0060907

Essential role of Sox2 for the establishment and maintenance of the germ cell line.
F Campolo, M Gori, R Favaro, S Nicolis, M Pellegrini, F Botti, P Rossi, EA Jannini, S Dolci.
Stem Cells. 2013 Jul;31(7):1408-21. doi: 10.1002/stem.1392.

HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS.
AM Madera, D Poon, A Smith
U.S. Patent 20,130,096,149, issued April 18, 2013.
10 drugs from Axon Medchem have been cited

Tcf15 Primes Pluripotent Cells for Differentiation.
OR Davies, CY Lin, A Radzisheuskaya, X Zhou, J Taube, G Blin, A Waterhouse, AJH Smith, S Lowell.
Cell Reports 2013, 3(2), 472-484.

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal.
Y Sanchez-Ripoll, HK Bone, T Owen, AMV Guedes, E Abranches, B Kumpfmueller, RV Spriggs, D Henrique, MJ Welham.
PLoS ONE 2013, 8(4), e60148. doi:10.1371/journal.pone.0060148

LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP.
T Hochdörfer, C Tiedje, DJ Stumpo, PJ Blackshear, M Gaestel, M Huber.
Cell Signal. 2013, 25(6), 1339–1347.

Efficient Generation of Rat Induced Pluripotent Stem Cells Using a Non-Viral Inducible Vector.
C Merkl, A Saalfrank, N Riesen, R Kühn, A Pertek, S Eser, MS Hardt, A Kind, D Saur, W Wurst, A. Iglesias, A Schnieke.
PLoS ONE 2013, 8(1): e55170. doi:10.1371/journal.pone.0055170

Deep proteome coverage based on ribosome profiling aids MS-based protein and peptide discovery and provides evidence of alternative translation products and near-cognate translation initiation events.
G Menschaert, W Van Criekinge, T Notelaers, A Koch, J Crappe, K Gevaert and P Van Damme.
Mol Cell Proteomics. 2013 Jul;12(7):1780-90. doi: 10.1074/mcp.M113.027540. 

BRAF mutations in chronic lymphocytic leukemia.
BMC Jebaraj, D Kienle, A Bühler, D Winkler, H Döhner, S Stilgenbauer & T Zenz.
Leukemia & lymphoma, 2013, 54(6), 1177-1182.

Derivation of porcine induced pluripotent stem cells and somatic cells gene targeting in pig.
Xinxin Cu (2013) PhD thesis.
TECHNISCHE UNIVERSITÄT MÜNCHEN, Lehrstuhl für Biotechnologie der Nutztiere.
2i: PD0325901 and CHIR99021 from Axon Medchem

Liver organoid, uses thereof and culture method for obtaining them
MH Ortega, JC Clevers.
US 20130189327 A1

(33 publications from 2010 till 2012; *This is an incomplete list extracted from 64 citations)
Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry.
E Pozo-Guisado, DG Campbell, M Deak, A. Álvarez-Barrientos, NA Morrice, IS Álvarez, DR Alessi, and FJ Martín-Romero*
J. Cell Sci. 2010, 123 (18), 3084-3093.
(... PD184352 and PD0325901 from Axon Medchem...) 

Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells.
MY Chang, D Kim, CH Kim, HC Kang, E Yang, et al.
PLoS ONE 2010, 5(3): e9838.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Generation of genetically modified rats from embryonic stem cells.
Masaki Kawamata and Takahiro Ochiya
PNAS 2010, 107 (32), 14223-14228.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Neural induction intermediates exhibit distinct roles of Fgf signaling.
J Sterneckert, M Stehling, C Bernemann, MJ Araúzo-Bravo, B Greber, L Gentile, C Ortmeier, M Sinn, G Wu, D Ruau, M Zenke, R Brintrup, DC Klein, K Ko, HR Schöler.
STEM CELLS 2010, 28 (10), 1772-1781. 

A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.
K Horie, C Kokubu, J Yoshida, K Akagi, A Isotani, A Oshitani, K Yusa, R Ikeda, Y Huang, A Bradley & J Takeda.
Nature Methods 2011, 8, 1071-1077. doi:10.1038/nmeth.1739
... Serum-free medium containing 2i (MEK inhibitor PD0325901 (Axon Medchem) plus GSK3 inhibitor CHIR99021 (Axon Medchem)) was prepared and used in phenotypic analyses. 

FGF signalling inhibits neural induction in human embryonic stem cells.
B Greber, P Coulon, M Zhang, S Moritz, S Frank, AJ Müller-Molina, MJ Araúzo-Bravo, DW Han, HC Pape and HR Schöler.
EMBO J. 2011, 30, 4874-4884. 

Distinct Developmental Ground States of Epiblast Stem Cell Lines Determine Different Pluripotency Features.
C Bernemann, B Greber, K Ko, J Sterneckert, DW Han, MJ Araúzo-Bravo, HR Schöler*
Stem Cells 2011, 29 (10), 1496-1503.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Rat Embryonic Stem Cell Derivation and Propagation.
Ping Li, Eric N. Schulze, Chang Tong and Qi-Long Ying.
ADVANCED PROTOCOLS FOR ANIMAL TRANSGENESIS. Springer Protocols Handbooks, 2011, 457-475, DOI: 10.1007/978-3-642-20792-1_19
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.
A Isotani, H Hatayama, K Kaseda, M Ikawa, M Okabe*.
Genes to Cells 2011, 16 (4), 397–405.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Loss of Dnd1 facilitates the cultivation of genital ridge-derived rat embryonic germ cells.
E Northrup, R Eisenblätter, S Glage, C Rudolph, M Dorsch, B Schlegelberger, HJ Hedrich, NH Zschemisch.
Exp. Cell Res. 2011, 317 (13), 1885–1894.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

T Cell-Signaling Network Analysis Reveals Distinct Differences between CD28 and CD2 Costimulation Responses in Various Subsets and in the MAPK Pathway …
ME Kalland, NG Oberprieler, T Vang, K Taskén and KM Torgersen.
J. Immunol. 2011, 187 (10), 10 5233-5245 

METHOD FOR PRODUCING HETEROGENOUS EMBRYONIC CHIMERIC ANIMAL USING A STEM CELL.
US Patent Application 20110283374.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Effect of Small Molecule Supplements during In Vitro Culture of Mouse Zygotes and Parthenogenetic Embryos on Hypoblast Formation and Stem Cell Derivation.
K. Versieren, M. Van der Jeught, T. O’Leary, G. Duggal, J. Gerris, S. Chuva de Sousa Lopes, B. Heindryckx and P. De Sutter.
STEM CELL REVIEWS AND REPORTS 2012, DOI: 10.1007/s12015-012-9382-7
(Axon 1386 - CHIR 99021 was also tested in this paper) 

In vitro expansion and functional recovery of mature hepatocytes from mouse adult liver.
H Ito, A Kamiya*, K Ito, A Yanagida, K Okada, H Nakauchi*
Liver International 2012, 32 (4), 592-601.  doi: 10.1111/j.1478-3231.2011.02741.x
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Identification of Rat Rosa26 Locus Enables Generation of Knock-in Rat Lines Ubiquitously Expressing tdTomato.
T Kobayashi, M Kato-Itoh, T Yamaguchi, C Tamura, M Sanbo, M Hirabayashi, and H Nakauchi.
Stem Cells and Development. 2012, 21(16): 2981-2986.  doi:10.1089/scd.2012.0065.
(Axon 1386 - CHIR 99021 was also tested in this paper) 

Kinetics and activation requirements of contact-dependent immune suppression by human regulatory T cells.
KW Brudvik, BA Bjørnbeth, A Foss, K Taskén and EM Aandahl.
J Immunol. 2012, 188 (11), 5459-5466.
... Imatinib mesylate, CP 690550, and PD 0325901 were purchased from Axon Medchem ... 

The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
R Korhonen, N Huotari, T Hömmö, T Leppänen, E Moilanen.
Mol. Immunol. 2012, 51 (2), 219–226. 

Sirt1, p53 and p38MAPK are Crucial Regulators of Detrimental Phenotypes of ESCs with Max Expression Ablation.
T Hishida, Y Nozaki, Y Nakachi, Y Mizuno…
STEM CELLS, 2012, 30(8), 1634–1644. DOI: 10.1002/stem.1147 

Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells.
AD Egorova, K Van der Heiden, S Vd Pas, P Vennemann, C Poelma, MC DeRuiter, MJTH Goumans, AC Gittenberger-de Groot, P ten Dijke, RE Poelmann, BP Hierck.
Devel. Dynamics 2011, 240 (7), 1670–1680. 

MEK/Erk-based negative feedback mechanism involved in control of Steel Factor-triggered production of Krüppel-like factor 2 in mast cells.
JS Marschall, T Wilhelm, W Schuh, M Huber.
Cell. Signal. 2012, 24 (4), 879–888.
(...  PD0325901 as well as PD184352 from axon Medchem ...) 

Dynamic interaction networks in a hierarchically organized tissue
DC Kirouac, C Ito, E Csaszar, A Roch… - Molecular systems …, 2010 - nature.com
Mol. Systems Biol. 2012, 6, 417  doi:10.1038/msb.2010.71
(... LY294002, Degulin, U73122, BAY439006, and PD0325901 were purchased from Axon Medchem ...) 

Small Molecule-Assisted, Line-Independent Maintenance of Human Pluripotent Stem Cells in Defined Conditions.
S Frank, M Zhang, HR Schöler, B Greber.
PLoS ONE 2012, 7(7): e41958. doi:10.1371/journal.pone.0041958

Two distinct knockout approaches highlight a critical role for p53 in rat development.
M Kawamata & T Ochiya. - nature.com -
Scientific Reports 2012, 2, 945. doi:10.1038/srep00945

Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development.
K Okada, A Kamiya, K Ito, A Yanagida, H Ito, H Kondou, H Nishina, and H Nakauchi.
Stem Cells and Development. 2012, 21(7): 1124-1133. doi:10.1089/scd.2011.0229.
2i: CHIR99021 (Axon 1386) and PD0325901 (Axon 1408) were procured from Axon Medchem.

METHOD FOR CONSTRUCTING CHIMERIC RAT USING RAT EMBRYONIC STEM CELLS. 
T Ochiya, M Kawamata - European Patent EP 2508595, issued October 10, 2012. 

INDUCED HEPATIC STEM CELL AND PROCESS FOR PRODUCTION THEREOF, AND APPLICATIONS OF THE CELL.
T Ishikawa, K Hagiwara, and T Ochiya.
European Patent EP 2532741, issued December 12, 2012. 

Novel method for rapid and efficient generation of neuroectoderm cells and peripheral neurons from pluripotent stem cells.
B Greber, and H Schöler.
European Patent EP 2497825, issued September 12, 2012. 

Compounds and compositions as protein kinase inhibitors.
AQ Costales, S Huang, JX Jin, Z Liu, S Pecchi, D Poon, J Tellew, and Q Zhang.
U.S. Patent 8,242,260, issued August 14, 2012. 

* Many investigators in stem cell research often use CHIR 99021 (Axon 1386) and PD0325901 (Axon 1408) together as 2i.

See publications used CHIR 99021 from Axon Medchem

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