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PD0325901
- Mirdametinib
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C16H14F3IN2O4
- MW: 482.19
Description
Potent, highly specific non-ATP-competitive inhibitor of MEK (aka MKK) 1/2; a derivative of PD184352 (Axon 1368) to improve bioavailability; clinical candidate and highly recommended tool to inhibit MKK1 or MKK1 plus MKK5 in cells.
* PD0325901 and CHIR99021 (Axon 1386) from Axon Medchem are often used together as perfect 2i in stem cell research (Axon 2128).
*Promotion: PD 0325901 is also part of Inhibitor Set(s):
| Stem Cell 2i inhibitor Set (Axon 2128) |
| Stem Cell 4i inhibitor Set (Axon 5009) |
| Naive Stem Cell NHSM inhibitor Set (Axon 5010) |
| Naive Stem Cell 5i inhibitor Set (Axon 5011) |
Prime Source Information:
PD0325901 from Axon Medchem has been procured by many labs as drug standard for generating reliable and reproducible biological data, evidenced by many recent publications.
More Information
| Parent CAS No. | 391210-10-9 |
|---|---|
| Chemical Name | N-((R)-2,3-Dihydroxy[propoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide |
| extra_info | . |
| SMILES | C([C@@H](CO)O)ONC(=O)C1=C(NC2C(F)=CC(I)=CC=2)C(F)=C(F)C=C1 |&1:1,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1 |
| InChiKey | SUDAHWBOROXANE-SECBINFHSA-N |
| CID | 9826528 |
| Short Description | MEK1 inhibitor |
References
- J Bain et al. The selectivity of protein kinase inhibitors: a further update.Biochem J. 2007, 408(Pt 3), 297–315.
- QL Ying et al. The ground state of embryonic stem cell self-renewal. Nature, 2008, 453, 519-523.
- SD Barrett et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg. Med. Chem. Lett. 2008, 18, 6501-6504.
- C Frémin and S Meloche. From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J. Hematol. Oncol. 2010, 3, 8.
- List of publications using PD0325901 (Axon 1408) purchased from Axon Medchem
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